Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.

Abstract:

:Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin proteins in cellular senescence. Here we analysed the role of lamin B receptor (LBR), a nuclear envelope protein that regulates heterochromatin organization, in cellular senescence induced by excess thymidine. We then found that the LBR protein was down-regulated and showed aberrant localization in cells upon induction of cellular senescence by excess thymidine. Additionally, we also found that knock-down of LBR facilitated the induction of cellular senescence by excess thymidine in cancerous HeLa cells, and importantly, it induced cellular senescence in normal human diploid fibroblast TIG-7 cells. These results suggested that decreased LBR function is involved in the induction of cellular senescence in human cells.

journal_name

Mech Ageing Dev

authors

Arai R,En A,Takauji Y,Maki K,Miki K,Fujii M,Ayusawa D

doi

10.1016/j.mad.2019.01.001

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

25-32

eissn

0047-6374

issn

1872-6216

pii

S0047-6374(18)30092-7

journal_volume

178

pub_type

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