Integrated study on comparative transcriptome and skeletal muscle function in aged rats.

abstract：:Aging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal m...

journal_title：Mechanisms of ageing and development

authors： Piccirillo F,Carpenito M,Verolino G,Chello C,Nusca A,Lusini M,Spadaccio C,Nappi F,Di Sciascio G,Nenna A

更新日期：2019-12-01 00:00:00

abstract：:Lipofuscin accumulation in cultured rat myocardial cells is considered an index of intra-lysosomal oxidative reactions and was registered by autofluorescence measurements. Lipofuscinogenesis in secondary lysosomes is thought to be a consequence of Fenton reactions, and is much enhanced by oxidative stress obtained by ...

journal_title：Mechanisms of ageing and development

authors： Marzabadi MR,Jones C,Rydström J

更新日期：1995-06-09 00:00:00

abstract：:Glucocorticoids promote the development of many organs including intestine. At the cellular level, the activity of glucocorticoids is regulated by 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) which converts active glucocorticoids to inactive metabolites. As 11 beta HSD is also expressed in the intestine, this en...

journal_title：Mechanisms of ageing and development

authors： Pohlová I,Miksík I,Pácha J

更新日期：1997-11-01 00:00:00

abstract：:It has been previously well documented that partial pressure of oxygen (PO2) and weight-specific rate of O2 consumption in chick embryo (Gallus gallus domesticus) transiently increase midway through the 21-day in ovo incubation period. The present study found that these oxidative changes were paralleled by the concent...

journal_title：Mechanisms of ageing and development

authors： Wilson JX,Lui EM,Del Maestro RF

更新日期：1992-08-01 00:00:00

abstract：:The present study examined the effect of a 40% reduction in caloric intake (CR) versus ad libitum (AL) feeding on retinal aging. CR- and AL-fed Brown Norway (BN) rats were obtained at 12, 24 and 30 months of age from the National Center for Toxicological Research (NCTR). Age-dependent declines in outer nuclear layer (...

journal_title：Mechanisms of ageing and development

authors： Obin M,Pike A,Halbleib M,Lipman R,Taylor A,Bronson R

更新日期：2000-03-13 00:00:00

abstract：:In an attempt to provide additional quantitative markers of senescence in the nematode Caenorhabditis elegans, we have identified age-dependent increases in four lysosomal enzymes: acid phosphatase, beta-N-acetyl-D-glucosaminidase, beta-D-glucosidase, and alpha-D-mannosidase. These enzymes were judged to be lysosomal ...

journal_title：Mechanisms of ageing and development

authors： Bolanowski MA,Jacobson LA,Russell RL

更新日期：1983-03-01 00:00:00

abstract：:In this paper, we approach the problem of attempting to understand senescence by understanding the complexity and hierarchical structure of mammalian organisms. To do this, we make use of some concepts from abstract relational biology; in particular, graph theory. We subsequently utilize these concepts to develop the ...

journal_title：Mechanisms of ageing and development

authors： Witten M

更新日期：1984-10-31 00:00:00

abstract：:The aim of the present study was to measure protein synthesis in regenerating liver and to evaluate the impact of malnutrition in young and old rats. Two groups of male Wistar rats were used: young rats (4 months old) and old rats (18 months old). The rats were allocated to malnutrition or ordinary food intake for 1 w...

journal_title：Mechanisms of ageing and development

authors： Carrillo MC,Carnovale CE,Favre C,Monti JA,Scapini C

更新日期：1996-10-04 00:00:00

abstract：:Many molecular chaperones are also known as heat shock proteins because they are synthesised in increased amounts after brief exposure of cells to elevated temperatures. They have many cellular functions and are involved in the folding of nascent proteins, the re-folding of denatured proteins, the prevention of protei...

journal_title：Mechanisms of ageing and development

authors： Proctor CJ,Soti C,Boys RJ,Gillespie CS,Shanley DP,Wilkinson DJ,Kirkwood TB

更新日期：2005-01-01 00:00:00

abstract：:Long-term cultures of human umbilical endothelial cells were examined for changes in cell growth, cell density, cell volume, occurrence of multinucleated cells, prostacyclin production and negative charge of the cell surface during in vitro cellular ageing. The changes observed were consistent with the previously desc...

journal_title：Mechanisms of ageing and development

authors： Hasegawa N,Yamamoto M,Imamura T,Mitsui Y,Yamamoto K

更新日期：1988-12-01 00:00:00

abstract：:In this study, we proposed a hypothesis that chromatin of mouse hepatocytes exhibits age-related reduction of fractal dimension. This hypothesis was based on previously published works demonstrating that complexity of biological systems such as tissues, decreases during the process of physiological aging. Liver tissue...

journal_title：Mechanisms of ageing and development

authors： Pantic I,Petrovic D,Paunovic J,Vucevic D,Radosavljevic T,Pantic S

更新日期：2016-07-01 00:00:00

abstract：:This paper presents evidence derived from the selective use of codons in ca. 40 eukaryotic genes (or messages derived from them) that codon usage is one of the most conserved features of messages for specific cell products. The theory has been developed by several investigations that the kinds of products of many if n...

journal_title：Mechanisms of ageing and development

authors： Strehler B,North D

更新日期：1982-04-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in protecting animals from aging and age-associated pathology, we generat...

journal_title：Mechanisms of ageing and development

authors： Paul A,Belton A,Nag S,Martin I,Grotewiel MS,Duttaroy A

更新日期：2007-11-01 00:00:00

abstract：:Changes in activity of some hepatic enzymes related to UDP-glucuronic acid conjugation (UDP-glucose dehydrogenase and UDP-glucuronyl transferase) and glutathione-related enzymes (glutathione reductase and glutathione peroxidase) were investigated in male and female Wistar rats as a function of age. UDP-glucose dehydro...

journal_title：Mechanisms of ageing and development

authors： Santa Maria C,Machado A

更新日期：1988-08-01 00:00:00

abstract：:Elastase and lipid levels of the plasmas of subjects and of those who have suffered a stroke have been measured, and it has been shown that the normal age related fall in elastase content is mirrored more closely by the fall in high density lipoprotein cholesterol than by changes in total cholesterol. After a stroke a...

journal_title：Mechanisms of ageing and development

authors： Hall DA,Elridi SS,Zajac A,Middleton RS

更新日期：1980-11-01 00:00:00

abstract：:We examined the effects of voluntary exercise on glucose transporter concentration in skeletal muscle from young adult and old female Long-Evans rats. Rats had free access to voluntary running wheels beginning at 4 months of age or remained sedentary. Exercising rats ran approximately 7.5, 6.2, 5.6 and 5.3 km/day duri...

journal_title：Mechanisms of ageing and development

authors： Gulve EA,Rodnick KJ,Henriksen EJ,Holloszy JO

更新日期：1993-02-01 00:00:00

abstract：:Neurons that degenerate in the brains of persons with Alzheimer's disease accumulate mitochondrial amyloid precursor protein (APP), which is thought to negatively affect mitochondrial function and cellular homeostasis. Because proteins that enter mitochondria require assistance from chaperone proteins, we hypothesized...

journal_title：Mechanisms of ageing and development

authors： Yang TT,Hsu CT,Kuo YM

更新日期：2009-09-01 00:00:00

abstract：:Falls following a meal occur commonly in older persons. These falls have been related to a decrease in postprandial blood pressure due to carbohydrates in the meal. The mechanism by which this occurs is not known. In this study, we examined the possible role of a vasodilatory peptide, calcitonin gene-related peptide (...

journal_title：Mechanisms of ageing and development

authors： Edwards BJ,Perry HM 3rd,Kaiser FE,Morley JE,Kraenzle D,Stevenson R,Kreutter D

更新日期：1996-06-07 00:00:00

abstract：:This study attempts to elucidate the molecular mechanisms underlying the ageing-dependent cAMP profiles in human diploid fibroblasts stimulated by lysophosphatidic acid (LPA). In senescent cells, LPA-dependent Gialpha activation was reduced, with a consequent reduction in Gi-suppressed cAMP levels, without alterations...

journal_title：Mechanisms of ageing and development

authors： Jang IS,Rhim JH,Kim KT,Cho KA,Yeo EJ,Park SC

更新日期：2006-05-01 00:00:00

abstract：:We used a fluorescence differential display--PCR (FDD-PCR) technique to analyze the genes expressed in mouse kidneys collected at nine different developmental stages ranging from 3 days to 15 months after birth. We found ten genes that were age-dependent and differentially-expressed in the kidneys during our experimen...

journal_title：Mechanisms of ageing and development

authors： Iida R,Yasuda T,Aoyama M,Tsubota E,Matsuki T,Kishi K

更新日期：2000-02-07 00:00:00

abstract：:Possible alterations in the population of poly(A)(+)mRNA during ageing were investigated by translation in vitro of poly(A)(+)mRNA from the liver, kidney and brain of male ddY mice of different ages. [35S]Methionine-labeled translation products were analysed by two-dimensional polyacrylamide gel electrophoresis follow...

journal_title：Mechanisms of ageing and development

authors： Anzai K,Imazato C,Goto S

更新日期：1983-10-01 00:00:00

abstract：:Significant changes are observed in wet weight, microsomal protein content and enzymes of purified rough and smooth microsomes of liver during postnatal development and ageing of female Wistar rats. Protein content of total microsomes increases up to 15 days of age and remains steady during subsequent development, unl...

journal_title：Mechanisms of ageing and development

authors： Devasagayam TP,Pushpendran CK,Eapen J

更新日期：1983-03-01 00:00:00

abstract：:Age related change of the human minor pectoral muscles was biochemically demonstrated. Myosin-ATPase activity was significantly decreased with age, and was activated with Tris. The degree of the activation by Tris was observed to be lower in old aged patients than in the young. Furthermore, at low concentration of CaC...

journal_title：Mechanisms of ageing and development

authors： Nakano M,Baba H,Tauchi H,Sato T

更新日期：1985-07-01 00:00:00

abstract：:Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

journal_title：Mechanisms of ageing and development

authors： Robinson N,Grabowski P,Rehman I

更新日期：2018-09-01 00:00:00

abstract：:Prostaglandin (PG) synthesis by human embryo lung fibroblasts in culture was determined with increasing population doubling. These cultures synthesized PGE2, PGF2 alpha, PGI2 (prostacyclin) and TXA2 (thromboxane A2) in response to fetal bovine serum or ascorbic acid. Changes in prostaglandin synthesis by these cells d...

journal_title：Mechanisms of ageing and development

authors： Polgar P,Taylor L

更新日期：1980-04-01 00:00:00

abstract：:The release of cytokines is of crucial importance in the regulation of the type and magnitude of the immune response in the elderly. A number of studies have shown different levels of cytokine production in the elderly. In the present study, a range of polymorphisms were chosen within the genes of cytokines (IL-2, IL-...

journal_title：Mechanisms of ageing and development

authors： Ross OA,Curran MD,Meenagh A,Williams F,Barnett YA,Middleton D,Rea IM

更新日期：2003-02-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in livers of young-adult and old rats administered carbon tetrachloride or vehicle. IL-1beta levels were higher and IL-6 levels were lower in old rats than in young-adult rats. Carbon tetrachlor...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,DeCicco LA,Hornbrook KR,Yamano T

更新日期：1999-05-03 00:00:00

abstract：:In agreement with previous studies we show an age-related increase in serum levels of hyaluronic acid in healthy individuals. Levels in Down's syndrome persons were slightly higher, especially in those with hypothyroidism. This provides further evidence that the normal ageing process is accelerated in Down's syndrome....

journal_title：Mechanisms of ageing and development

authors： Hutchin T,Martin L,Prasher V,Sinclair AJ

更新日期：1998-12-01 00:00:00

abstract：:Chondrocytes derived from chick embryos can be successfully implanted in defects of adult chick articular cartilage surfaces. Such implants thrive in their implantation site and create a new articular surface. The chondrocytes mature and hypertrophy in the orthotopic site without invoking an immune response. Eventuall...

journal_title：Mechanisms of ageing and development

authors： Robinson D,Halperin N,Nevo Z

更新日期：1989-10-01 00:00:00

abstract：:A few reports suggest that pigmented granules found in molluscan neurons accumulate with age as do lipofuscin granules in vertebrate cells; however, no reports on molluscan neurons include detailed descriptions of granule accumulation or histochemical tests to identify the pigment as lipofuscin-like. In this study lig...

journal_title：Mechanisms of ageing and development

authors： Robles LJ

更新日期：1978-01-01 00:00:00