Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.

abstract：:Apoptosis plays a central role in the homeostasis of the immune system. During aging, there is an altered regulation of pivotal molecules that are responsible for the regulation of this type of cell death, such as those of the Fas/FasL system. Understanding the regulation of these genes can help to clarify, at least i...

journal_title：Mechanisms of ageing and development

authors： Pinti M,Troiano L,Nasi M,Monterastelli E,Moretti L,Bellodi C,Mazzacani A,Mussi C,Salvioli G,Cossarizza A

更新日期：2003-04-01 00:00:00

abstract：:There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific...

journal_title：Mechanisms of ageing and development

authors： Descamps O,Riondel J,Ducros V,Roussel AM

更新日期：2005-11-01 00:00:00

abstract：:The kidney glomeruli of 9-month-old intact, 23-month-old intact, and 23-month-old hypophysectomized female rats were examined by scanning and transmission electron microscopy. With increasing age, the glomeruli increased in diameter and more podocyte microvilli were found. Hypophysectomy (4 months before sacrifice) re...

journal_title：Mechanisms of ageing and development

authors： Johnson JE Jr,Cutler RG

更新日期：1980-05-01 00:00:00

abstract：:Falls following a meal occur commonly in older persons. These falls have been related to a decrease in postprandial blood pressure due to carbohydrates in the meal. The mechanism by which this occurs is not known. In this study, we examined the possible role of a vasodilatory peptide, calcitonin gene-related peptide (...

journal_title：Mechanisms of ageing and development

authors： Edwards BJ,Perry HM 3rd,Kaiser FE,Morley JE,Kraenzle D,Stevenson R,Kreutter D

更新日期：1996-06-07 00:00:00

abstract：:Older adults who are at risk of developing influenza illness, have a low level of influenza virus-stimulated cytotoxic T lymphocyte (CTL) activity as measured by an assay of granzyme B (GrB). The purpose of this study was to determine whether aging affected memory CTL populations identified by GrB expression in influe...

journal_title：Mechanisms of ageing and development

authors： Xie D,McElhaney JE

更新日期：2007-05-01 00:00:00

abstract：:DNA methylation (DNAm) is a fundamental biochemical modification which occurs over the lifespan of an individual and it is a significant component in the aging process. Methylation level of CpG sites plays an important role in finding the age of a person. Different approaches were used to extract age-related CpG (AR-C...

journal_title：Mechanisms of ageing and development

authors： Goel N,Karir P,Garg VK

更新日期：2017-09-01 00:00:00

abstract：:Age-related changes in intestinal glucose absorption were studied using everted intestinal sacs and brush border membrane vesicles prepared from male F344 rats. Glucose uptake by everted intestinal sacs was greatest in young (2-3-month-old) as compared with adult (12-14-month-old) and old (24-month-old) rats. The grea...

journal_title：Mechanisms of ageing and development

authors： Doubek WG,Armbrecht HJ

更新日期：1987-06-01 00:00:00

abstract：:Concanavalin A (Con A)-mediated red blood cell (RBC) adsorption with the RBC coating method (in which Con A-coated RBC's are adsorbed to fibroblasts) was greatly increased by glutaraldehyde fixation of RBCs before Con A-coating and decreased by the fixation of fibroblasts. On the other hand, RBC adsorption with the fi...

journal_title：Mechanisms of ageing and development

authors： Aizawa S,Kurimoto F

更新日期：1979-11-01 00:00:00

abstract：:Cell-free protein synthesis by mouse liver ribosomes was examined as a function of the age of individual ribosome donors. In two strains of mouse, one long-lived and one short-lived, both the fraction of polyribosomes and the rate of in vitro ribosomal protein synthesis remained essentially constant throughout the lif...

journal_title：Mechanisms of ageing and development

authors： Shmookler Reis RJ

更新日期：1981-12-01 00:00:00

abstract：:Because muscle satellite cells have been implicated in the process of muscle growth and mass regulation, as well as regeneration, alterations in the capacity of satellite cells to differentiate and accumulate muscle specific proteins during aging could play a role in the process of senile muscle atrophy. Skeletal musc...

journal_title：Mechanisms of ageing and development

authors： Allen RE,McAllister PK,Masak KC,Anderson GR

更新日期：1982-01-01 00:00:00

abstract：:Iron deficiency anaemia is prevalent in older age, particularly after the age of 80. Serum ferritin concentrations also decline, although there is no evidence to suggest that changes in iron stores are an inevitable consequence of ageing. Chronic inflammation is a common condition in older people, making the measureme...

journal_title：Mechanisms of ageing and development

authors： Fairweather-Tait SJ,Wawer AA,Gillings R,Jennings A,Myint PK

更新日期：2014-03-01 00:00:00

abstract：:Age related changes in some aspects of glutamate metabolism were followed in the brain of a short lived species of tropical murrel, Channa punctatus. Both ammonia and glutamine contents of brain increased with advancing age of the murrel. The glutamate dehydrogenase activity of brain increased during maturation phase ...

journal_title：Mechanisms of ageing and development

authors： Mahapatro N,Patnaik BK

更新日期：1993-05-01 00:00:00

abstract：:In a cell culture model of aging we have previously shown that there is an age-related decrease in the lipid dynamics of the proerythropoetic K562 cell membranes, as determined by the generalized polarization (GP) of the phase-sensitive lipid probe 2-dimethylamino-6-lauroylnaphthalene (Laurdan) (T. Parasassi, M. Di St...

journal_title：Mechanisms of ageing and development

authors： Levi M,Wilson P,Nguyen S,Iorio E,Sapora O,Parasassi T

更新日期：1997-08-01 00:00:00

abstract：:Non-proliferative and proliferative myeloid, and lymphoid and erythroid bone marrow cells were studied in aging female C3H mice. A chronobiological approach was used and mice aged 16, 21 and 26 months were examined vs. 3 month-old mice every 3 h during the 24-h period in three different experiments. Significant circad...

journal_title：Mechanisms of ageing and development

authors： Sletvold O,Laerum OD,Riise T

更新日期：1988-01-01 00:00:00

abstract：:Elevated reactive oxygen species (ROS) levels have been observed in mammals during aging, implying an important role of ROS in the aging process. Most bird species are known to live longer and to contain lower ROS levels than mammals of the same body weight. The influence of ROS on the aging process of birds has been ...

journal_title：Mechanisms of ageing and development

authors： Strecker V,Mai S,Muster B,Beneke S,Bürkle A,Bereiter-Hahn J,Jendrach M

更新日期：2010-01-01 00:00:00

abstract：:We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total C...

journal_title：Mechanisms of ageing and development

authors： Battino M,Gorini A,Villa RF,Genova ML,Bovina C,Sassi S,Littarru GP,Lenaz G

更新日期：1995-03-17 00:00:00

abstract：:In predicting the degree of brain atrophy as measured by CT, the AGP score and a few clinical variables were of some remarkable value. Especially the variables related to memory disorders and lack of insight are easily and reliably assessed during the course of the examination. In comparison to other more widely used ...

journal_title：Mechanisms of ageing and development

authors： Gutzmann H,Avdaloff W

更新日期：1980-11-01 00:00:00

abstract：:The content of alpha-amylase, the major exocrine secretory protein from rat parotid glands, was studied in young adult and aged rat tissue. alpha-Amylase protein was determined with an enzyme-linked immunosorbent assay. This employed antisera, produced against alpha-amylase purified from young adult rats, but which re...

journal_title：Mechanisms of ageing and development

authors： Baum BJ,Levine RL,Kuyatt BL,Sogin DB

更新日期：1982-05-01 00:00:00

abstract：:The purpose of this study was to determine the feasibility of using a recently developed procedure, dual-energy x-ray absorptiometry, to determine body composition in rats as a function of aging. Results were obtained that were consistent with previous findings for male rats. ...

journal_title：Mechanisms of ageing and development

authors： Rikans LE,Venkataraman PS,Cai Y

更新日期：1993-10-01 00:00:00

abstract：:Morphometric comparison of freeze-fractured mitochondria in flight muscles of adult (37-day-old) and old (68-day-old) houseflies revealed a 28% decrease of cristae in the old flies. The major membrane change with age was an increase in the 90-120-A particles in the inner membrane external face concomitant with a loss ...

journal_title：Mechanisms of ageing and development

authors： Turturro A,Shafiq SA

更新日期：1981-06-01 00:00:00

abstract：:The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidat...

journal_title：Mechanisms of ageing and development

authors： Agarwal S,Sohal RS

更新日期：1994-07-01 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:A comprehensive study on GSH metabolism in relation to some markers of oxidative and energy status in rat cerebral cortex as a function of age was performed. Reduced GSH, total GSH and the GSH Redox Index decreased both during growth (defined as the period between 1 and 5 months) and during aging (defined as the perio...

journal_title：Mechanisms of ageing and development

authors： Iantomasi T,Favilli F,Marraccini P,Stio M,Treves C,Quattrone A,Capaccioli S,Vincenzini MT,Quatrone A corrected to Quattrone A

更新日期：1993-08-01 00:00:00

abstract：:The lipid peroxidation and activities of main enzymes involved in the peroxide metabolism were measured at resting conditions and after completion of a 2-month treatment with H2O2. At the start of the experiments 1- and 3-month-old female BALB/c mice received either a high dose of H2O2 (0.5% H2O2 in drinking water; in...

journal_title：Mechanisms of ageing and development

authors： Imre S,Tóth F,Fachet J

更新日期：1984-12-01 00:00:00

abstract：:In the rat, kininogens are produced from two distinctly regulated gene families, T- and K-kininogens. We have previously established that T-kininogen (T-KG, thiostatin) gene expression is increased in the liver of old rats, as compared to their younger counterparts. In this report, we have used Northern blot analysis ...

journal_title：Mechanisms of ageing and development

authors： Sierra F

更新日期：1995-10-13 00:00:00

abstract：:On a DNA basis, there is higher concentration of polysomes in the brain of newborn than in the brain of adult mice, but there is no maturation-dependent decrease in tRNA content during postnatal development. The amino acid incorporating activity of cell-free systems with polysomes or mitochondria from newborn brain ex...

journal_title：Mechanisms of ageing and development

authors： Goertz B

更新日期：1979-05-01 00:00:00

abstract：:In recent years, there was an increasing interest on candidate genes may play an important role in the development of Alzheimer's disease (AD). Several genome wide screens have undertaken so far or expanded recently, and suggested a number of genomic areas that may contain novel susceptibility genes for AD, in particu...

journal_title：Mechanisms of ageing and development

authors： Panza F,Colacicco AM,D'Introno A,Capurso C,Liaci M,Capurso SA,Capurso A,Solfrizzi V

更新日期：2006-01-01 00:00:00

abstract：:During adult life, the thymus involutes and thymic output of mature T cells drastically declines. The molecular events underlying this process are not well understood. Here, we present evidence of the importance of miRNAs in regulating T cell differentiation in the aged. miRNAs are a wide-ranging regulatory element in...

journal_title：Mechanisms of ageing and development

authors： Virts EL,Thoman ML

更新日期：2010-11-01 00:00:00

abstract：:Circulating antibodies in the sera of normal, healthy humans of different age groups to native DNA (nDNA) and reactive oxygen species modified DNA (ROS-DNA) was studied by competition ELISA. Sera from the young population (< 50 years of age) showed negligible levels of anti-DNA antibodies. In contrast, anti-DNA antibo...

journal_title：Mechanisms of ageing and development

authors： Ashok BT,Ali R

更新日期：1998-06-01 00:00:00

abstract：:Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this...

journal_title：Mechanisms of ageing and development

authors： Xie K,Kapetanou M,Sidiropoulou K,Bano D,Gonos ES,Djordjevic AM,Ehninger D

更新日期：2020-12-01 00:00:00