Abstract:
:Aging causes changes in body composition and energy balance. Estrogen plays an important role in body's metabolism. The aim of this study was to determine whether estrogen has beneficial effects on leptin responsiveness in aged mice. Young 4 months and aged 19-21 female mice fed High Fat Diet (HFD) or Standard Diet (SD) for 12 weeks and following received estrogen for 4 weeks. Responsiveness to leptin was compared by measuring energy balance parameters. Results showed that HFD caused weight gain compared to SD in young, but had no effect on aged animals. Estrogen reduced body weight, energy intake and visceral fat in young, while none of these parameters was affected in aged animals. Although there was leptin sensitivity in aged compared to ovariectomized animals, estrogen only improved the sensitivity of young to leptin. Estrogen prevented increase in TNF-α and a decrease in IL-10 in HFD young and aged animals. Response to estrogen depended on age, and estrogen increased leptin sensitivity only in young animals. Determining the exact mechanism of this action is suggested in future studies.
journal_name
Mech Ageing Devjournal_title
Mechanisms of ageing and developmentauthors
Farhadi Z,Khaksari M,Azizian H,Dabiri S,Fallah H,Nozari Mdoi
10.1016/j.mad.2019.111198subject
Has Abstractpub_date
2020-03-01 00:00:00pages
111198eissn
0047-6374issn
1872-6216pii
S0047-6374(19)30203-9journal_volume
186pub_type
杂志文章abstract::In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping...
journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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doi:10.1016/0047-6374(81)90129-9
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journal_title:Mechanisms of ageing and development
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更新日期:2017-06-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章,评审
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
doi:10.1016/j.mad.2011.12.003
更新日期:2012-02-01 00:00:00
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章,评审
doi:10.1016/j.mad.2006.01.021
更新日期:2006-05-01 00:00:00
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
pub_type: 杂志文章
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journal_title:Mechanisms of ageing and development
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