abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a common malignancy worldwide with poor outcomes. Therefore, it is important to identify a valuable prognostic biomarker for HCC. The present study aimed to identify novel prognostic biomarkers for HCC and evaluate the potential role of hub genes in HCC. METHODS:Weighted ge...

journal_title：Digestive diseases and sciences

authors： Wu M,Jiang L

更新日期：2021-01-26 00:00:00

abstract：:Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence...

journal_title：Digestive diseases and sciences

authors： Glynn H,Möller SP,Wilding H,Apputhurai P,Moore G,Knowles SR

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. AIMS:To investigate whether vitamin D suppr...

journal_title：Digestive diseases and sciences

authors： Wei X,Li X,Du J,Ge X,Sun Y,Li X,Xun Z,Liu W,Wang ZY,Li YC

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND AND AIMS:Patients with decompensated cirrhosis are at increased risk of mortality, even in absence of ACLF. The CLIF-C AD score (CLIF-C ADs) was proposed as a prognostic score but lacks sufficient validation. Our aim was to describe clinical characteristics and hospital evolution according to score groups an...

journal_title：Digestive diseases and sciences

authors： Baldin C,Piedade J,Guimarães L,Victor L,Duarte J,Veiga Z,Alcântara C,Fernandes F,Pereira JL,Pereira G

更新日期：2021-01-03 00:00:00

abstract：INTRODUCTION:Readmission for achalasia treatment is associated with significant morbidity and cost. Factors predictive of readmission would be useful in identifying patients at risk. METHODS:We performed a retrospective study using the Nationwide Readmission Database for the year 2016 and 2017. We collected data on ho...

journal_title：Digestive diseases and sciences

authors： Gupta K,Khan A,Chalhoub J,Groudan K,Desilets D

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:With an increasing number of available therapies for inflammatory bowel disease (IBD), little is known about patients' attitudes regarding IBD-related direct-to-consumer advertising (IBD-DTCA) and its impact on treatment decisions in clinical practice. METHODS:We administered a 58-item, mailed questionnai...

journal_title：Digestive diseases and sciences

authors： Gu P,Yang E,Chittajallu P,McNeill C,Singal AG,Kwon JH,Ahmed TF

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...

journal_title：Digestive diseases and sciences

authors： Gawron AJ,Staub J,Bielefeldt K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The risk of pancreatic cancer is elevated among people with new-onset diabetes (NOD). Based on Rochester Epidemiology Project Data, the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) model was developed and validated. AIMS:We validated the END-PAC model in a cohort of patients with NOD using r...

journal_title：Digestive diseases and sciences

authors： Chen W,Butler RK,Lustigova E,Chari ST,Wu BU

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The nature and outcomes of infection among patients with cirrhosis in safety-net hospitals are not well described. We aimed to characterize the rate of and risk factors for infection, both present on admission and nosocomial, in this unique population. We hypothesized that infections would be associ...

journal_title：Digestive diseases and sciences

authors： Fricker ZP,Mukthinuthalapati VVPK,Akinyeye S,Chalasani N,Attar BM,Balakrishnan M,Ghabril M,Long MT

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:In liver cirrhosis, intestinal mucus barrier is rarely studied. AIMS:This study aimed to investigate whether mucus barrier in ileum is altered in cirrhotic rats and its underlying mechanisms. METHODS:Thioacetamide was injected to induce liver cirrhosis in rats. Serum from portal vein blood, and ileum and l...

journal_title：Digestive diseases and sciences

authors： Zhang L,Tai Y,Tang S,Zhao C,Tong H,Gao J,Tang C

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...

journal_title：Digestive diseases and sciences

authors： Sinn DH,Lee HW,Paik YH,Kim DY,Kim YJ,Kim KM,Bae SH,Kim JH,Seo YS,Jang JY,Jang BK,Yim HJ,Kim HJ,Lee BS,Kim BH,Kim IH,Cho EY,Lee JI,Suh KS

更新日期：2021-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly morbid and prevalent cancer globally. While high quality evidence for mortality benefit of HCC surveillance is lacking, early detection of HCC is likely beneficial as prognosis is highly correlated with tumor stage. High risk populations, including patients with cirrhosis and...

journal_title：Digestive diseases and sciences

authors： Deng LX,Mehta N

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Amoxicillin, metronidazole, proton pump inhibitor, bismuth quadruple therapy had been shown to reliably achieve high eradication rates. The role of individual components remains undefined. AIM:To identify the additional benefit/role of bismuth in amoxicillin, metronidazole, proton pump inhibitor, bismuth qu...

journal_title：Digestive diseases and sciences

authors： Luo L,Ji Y,Yu L,Huang Y,Liang X,Graham DY,Lu H

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. AIMS:To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. METHODS:This...

journal_title：Digestive diseases and sciences

authors： Tanaka F,Takashima S,Nadatani Y,Otani K,Hosomi S,Kamata N,Taira K,Nagami Y,Tanigawa T,Fukumoto S,Watanabe T,Murakami Y,Kawada N,Fujiwara Y

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Percutaneous catheter drainage (PCD) performed pro-actively for collections in acute pancreatitis (AP) is associated with better outcomes. However, there are only a few studies describing this protocol. AIM:We aimed to evaluate an aggressive PCD protocol. METHODS:Consecutive patients with AP who underwent ...

journal_title：Digestive diseases and sciences

authors： Gupta P,Gupta J,Kumar C,Samanta J,Mandavdhare H,Sharma V,Sinha SK,Gupta V,Yadav TD,Dutta U,Kochhar R

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Lymphocytic esophagitis is a rare esophageal condition. Our knowledge of potential risk factors and treatment outcomes of lymphocytic esophagitis is limited. AIM:To investigate potential risk factors associated with the development of lymphocytic esophagitis and compare clinical characteristics and treatmen...

journal_title：Digestive diseases and sciences

authors： Zaver HB,Ghoz H,Malviya BJ,Brahmbhatt B,Palmer WC,Lacy BE,DeVault KR,Krishna M,Bi Y

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...

journal_title：Digestive diseases and sciences

authors： Sureshkumar S,Omang A,Anandhi A,Rajesh BS,Abdulbasith KM,Vijayakumar C,Palanivel C,Pazhanivel M,Kate V

更新日期：2020-11-18 00:00:00

abstract：BACKGROUND:An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown. AIMS:This study was aimed to explore the biological function and underlying mechanism of a new...

journal_title：Digestive diseases and sciences

authors： He W,Zhang D,Li D,Zhu D,Geng Y,Wang Q,He J,Wu J

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND AND AIMS:Obesity and diabetes are risk factors for advanced alcoholic liver disease, and both are components of the metabolic syndrome. We aimed to assess the prevalence of metabolic syndrome and its components in a contemporary US cohort of adults with alcoholic liver disease and compare it to a historic co...

journal_title：Digestive diseases and sciences

authors： Singh A,Amin H,Garg R,Gupta M,Lopez R,Alkhouri N,MCCullough A

更新日期：2020-11-01 00:00:00

abstract：:Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal ...

journal_title：Digestive diseases and sciences

authors： Kamal F,Khan MA,Lee-Smith W,Sharma S,Marella HK,Iqbal U,Mcdonough S,Aslam A,Ismail MK,Tombazzi C,Adler DG

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin in AH is unknown. AIMS:To investigate the association between my...

journal_title：Digestive diseases and sciences

authors： Shamseddeen H,Madathanapalli A,Are VS,Shah VH,Sanyal AJ,Tang Q,Liang T,Gelow K,Zimmers TA,Chalasani N,Desai AP

更新日期：2020-10-19 00:00:00

abstract：:The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be "bad" (proinflammatory) or "good" (anti-inflammatory). Mouse models of colitis show an increase in conjugated B...

journal_title：Digestive diseases and sciences

authors： Sitkin S,Pokrotnieks J

更新日期：2020-10-16 00:00:00

abstract：:The article "Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials", written by Remo Panaccione, John D. Isaacs, Lea Ann Chen, Wenjin Wang, Amy Marren, Kenneth Kwok, Lisy Wang, Gary Chan and Chinyu Su, was originally published electronically on...

journal_title：Digestive diseases and sciences

authors： Panaccione R,Isaacs JD,Chen LA,Wang W,Marren A,Kwok K,Wang L,Chan G,Su C

更新日期：2020-10-10 00:00:00

abstract：:Minimal lesions of the small bowel are mucosal changes characterized by an increased number of intraepithelial lymphocytes (with or without crypt hyperplasia) and normal villous architecture. Such changes are associated with a wide spectrum of conditions, ranging from food intolerances to infections, and from drugs to...

journal_title：Digestive diseases and sciences

authors： Volta U,Caio G,Ghirardi C,Lungaro L,Mansueto P,Carroccio A,De Giorgio R

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The expanded polytetrafluoroethylene (ePTFE)-covered stent has been widely used in the transjugular intrahepatic portosystemic shunt (TIPS) procedure. However, the epidemiologic data of acute TIPS occlusion (ATO) and the underlying mechanisms are scarce. AIMS:The purpose of this study was to evaluate the in...

journal_title：Digestive diseases and sciences

authors： Wang X,Luo X,Zhao M,Song J,Li X,Yang L

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Little is known on practice patterns of endoscopists for the management of Barrett's esophagus (BE) over the last decade. AIMS:Our aim was to assess practice patterns of endoscopists for the diagnosis, surveillance and treatment of BE. METHODS:All members of the Italian Society of Digestive Endoscopy (SIED...

journal_title：Digestive diseases and sciences

authors： Zagari RM,Eusebi LH,Galloro G,Rabitti S,Neri M,Pasquale L,Bazzoli F

更新日期：2020-09-28 00:00:00

abstract：:The original version of the article unfortunately contained an error in the surname of the second author, Dr. Ferdinando D'Amico in the author group. ...

journal_title：Digestive diseases and sciences

authors： Chateau T,D'Amico F,Zallot C,Mathieu N,Peyrin-Biroulet L

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Long non-coding RNAs have been acknowledged as the crucial regulators in the progression of human cancers, including gastric cancer (GC). Small nucleolar RNA host gene 10 (SNHG10) has been identified as an oncogene in several cancer types. Nonetheless, it is unclear whether SNHG10 exerts functions in GC cell...

journal_title：Digestive diseases and sciences

authors： Yuan X,Yang T,Xu Y,Ou S,Shi P,Cao M,Zuo X,Liu Q,Yao J

更新日期：2020-09-12 00:00:00

abstract：BACKGROUND:Oxaliplatin is one of the most effective chemotherapeutic drugs used for the treatment of colorectal cancer (CRC). However, intervention that attenuates the resistance of oxaliplatin is still required in the treatment of CRC. AIMS:To investigate the role of miR-325 in changing the oxaliplatin sensitivity to...

journal_title：Digestive diseases and sciences

authors： Zhang L,Chen H,Song Y,Gu Q,Zhang L,Xie Q,Xu J,Zhang M

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Anemia is a common systemic complication of inflammatory bowel disease (IBD) and is associated with worse disease outcomes, quality of life, and higher healthcare costs. AIMS:The purpose of this study was to determine how anemia severity impacts healthcare resource utilization and if treatment of anemia was...

journal_title：Digestive diseases and sciences

authors： Blaney H,Vu P,Mathew A,Snelling R,England J,Duong C,Hammonds K,Johnson C

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:Health education interventions are successful in modifying lifestyle. Functional health literacy (FHL) can determine patient adherence to clinic visits and procedures and may adversely impact the success of these interventions. AIMS:We sought to evaluate the hypothesis that a health education intervention w...

journal_title：Digestive diseases and sciences

authors： Shaw J,Patidar KR,Reuter B,Hajezifar N,Dharel N,Wade JB,Bajaj JS

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

journal_title：Digestive diseases and sciences

authors： Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Obesity is a known risk factor for diverticulitis. Our objective was to examine the less investigated impact of morbid obesity (MO) on admissions and clinical course of diverticulitis in a US representative database. METHODS:We retrospectively queried the 2010-2014 Nationwide Readmission Database t...

journal_title：Digestive diseases and sciences

authors： Patel K,Krishna SG,Porter K,Stanich PP,Mumtaz K,Conwell DL,Clinton SK,Hussan H

更新日期：2020-09-01 00:00:00

abstract：:The aim of this state-of-the-art narrative review is to evaluate the current evidence about the effectiveness of yoga as therapy for IBS and explore its potential mechanisms of action. The current literature suggests yoga is effective and safe and may target multiple mechanisms involved in treatment of IBS. Evidence f...

journal_title：Digestive diseases and sciences

authors： D'Silva A,MacQueen G,Nasser Y,Taylor LM,Vallance JK,Raman M

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The influence of direct-acting antivirals (DAAs) on chronic hepatitis C (CHC)-related hepatocellular carcinoma (HCC) remains controversial. We investigated the effect of eradicating CHC using DAAs on treatment outcomes in patients with CHC-related HCC treated with transarterial chemoembolization (TA...

journal_title：Digestive diseases and sciences

authors： Hyun HK,Cho EJ,Park SY,Hong YM,Kim SS,Kim HY,Heo NY,Park JG,Sinn DH,Kang W,Jeong SW,Song MJ,Park H,Lee D,Lee YS,Cho SB,An CS,Rhee HJ,Lee HW,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Lee JH,Yu SJ,Kim YJ,Yoo

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) g...

journal_title：Digestive diseases and sciences

authors： Xiao AH,Chang SY,Stevoff CG,Komanduri S,Pandolfino JE,Keswani RN

更新日期：2020-08-16 00:00:00

abstract：BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

journal_title：Digestive diseases and sciences

authors： Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

更新日期：2020-08-10 00:00:00

abstract：:The original version of the article unfortunately contained an error in the unit used for 'Distance of propagation'. The distance of propagation should be in the unit 'cm' rather than 'mm' throughout the manuscript. ...

journal_title：Digestive diseases and sciences

authors： Jaung R,Varghese C,Lin AY,Paskaranandavadivel N,Du P,Rowbotham D,Dinning P,O'Grady G,Bissett I

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE). AIMS:We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients. METHODS:We retros...

journal_title：Digestive diseases and sciences

authors： Alsahafi M,Mimish H,Salem F,Hijazi M,Aljahdli E,Jawa H,Bazarah S,Bokhary R,Qari Y,Mosli M

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVES:Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. DESIGN:We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Pat...

journal_title：Digestive diseases and sciences

authors： Talukdar R,Aslam M,Reddy DN,Nabi Z,Shava U,Ravikanth VV,Avanthi S,Govardhan B

更新日期：2020-08-04 00:00:00