abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...

journal_title：Oral oncology

authors： Howlett J,Hamilton S,Ye A,Jewett D,Riou-Green B,Prisman E,Thamboo A

更新日期：2021-01-24 00:00:00

abstract：PURPOSE:To investigate the incidence and clinical features of post-radiation nasopharyngeal necrosis (PRNN), and effectiveness of surgical intervention for its treatment. MATERIALS AND METHODS:Retrospectively, we reviewed 380 NPC patients who underwent high dose radiotherapy (RT) (single RT in 355 and re-RT in 25) fro...

journal_title：Oral oncology

authors： Yang K,Ahn YC,Nam H,Hong SD,Oh D,Noh JM

更新日期：2021-01-23 00:00:00

abstract：OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...

journal_title：Oral oncology

authors： Lin NC,Su IH,Hsu JT,Chang YJ,Tsai KY

更新日期：2021-01-16 00:00:00

abstract：OBJECTIVE:We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques. PATIENTS AND METHODS:We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-...

journal_title：Oral oncology

authors： Bedogni A,Bettini G,Bedogni G,Menapace G,Sandi A,Michelon F,Di Carlo R,Franco P,Saia G

更新日期：2021-01-01 00:00:00

abstract：:Mutations in histone modifying enzymes and histone variants were identified in multiple cancers in The Cancer Genome Atlas (TCGA) studies. However, very little progress and understanding has been made in identifying the contribution of epigenetic factors in head and neck squamous cell carcinoma (HNSCC). Here, we repor...

journal_title：Oral oncology

authors： Lin D,Lin B,Bhanot H,Riou R,Abt NB,Rajagopal J,Saladi SV

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). METHODS:Eligible patients were randomly assigned to an intervention or control group. Patients in the ...

journal_title：Oral oncology

authors： Huang S,Piao Y,Cao C,Chen J,Sheng W,Shu Z,Hua Y,Jiang F,Hu Q,Chen X,Chen Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

journal_title：Oral oncology

authors： Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. MATERIALS AND METHODS:All patients diagnosed with OSCC in E...

journal_title：Oral oncology

authors： Schneider K,Jakobsen KK,Jensen JS,Wessel I,Christensen A,Specht L,Lelkaitis G,Mirian C,Buchwald CV,Grønhøj C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To identify predictors of unplanned hospitalization and emergency department (ED) use among head and neck oncology patients. METHODS:Peer reviewed publications were identified through a systematic search of MEDLINE, Embase and Cochrane CENTRAL. Studies describing a cohort of HNC patients that detailed predic...

journal_title：Oral oncology

authors： Noel CW,Forner D,Wu V,Enepekides D,Irish JC,Husain Z,Chan KKW,Hallet J,Coburn N,Eskander A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:We aimed to develop a dual-task model to detect and segment nasopharyngeal carcinoma (NPC) automatically in magnetic resource images (MRI) based on deep learning method, since the differential diagnosis of NPC and atypical benign hyperplasia was difficult and the radiotherapy target contouring of NPC was lab...

journal_title：Oral oncology

authors： Ke L,Deng Y,Xia W,Qiang M,Chen X,Liu K,Jing B,He C,Xie C,Guo X,Lv X,Li C

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:examine the cost-effectiveness of routine Calcitonin (Ctn) screening test in the United States. MATERIALS AND METHODS:Markov chain model was developed that compares fine-needle aspiration biopsy (FNAB) with Ctn screening vs. FNAB-only in the evaluation of a thyroid nodule with non-highly suspicious findings...

journal_title：Oral oncology

authors： Al-Qurayshi Z,Kandil E,Randolph GW

更新日期：2020-11-01 00:00:00

abstract：:This systematic review analyses and describes the application and diagnostic accuracy of Artificial Intelligence (AI) methods used for detection and grading of potentially malignant (pre-cancerous) and cancerous head and neck lesions using whole slide images (WSI) of human tissue slides. Electronic databases MEDLINE v...

journal_title：Oral oncology

authors： Mahmood H,Shaban M,Indave BI,Santos-Silva AR,Rajpoot N,Khurram SA

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

journal_title：Oral oncology

authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis. METHODS:Immunohistochemical NOTCH1 and HES1 expression was jointly evaluated and co...

journal_title：Oral oncology

authors： Grilli G,Hermida-Prado F,Álvarez-Fernández M,Allonca E,Álvarez-González M,Astudillo A,Moreno-Bueno G,Cano A,García-Pedrero JM,Rodrigo JP

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Squamous cell carcinoma (SCC) of the tongue is one of the most common oral cancers, tongue dorsum being a site of low incidence of primary SCC. We report a rare case of SCC of the tongue dorsum in a 69-year-old man having a history of multiple cancers, including esophageal cancer, gastric cancer, and renal c...

journal_title：Oral oncology

authors： Yamasaki S,Tani R,Sakurai S,Toratani S,Okamoto T

更新日期：2020-10-01 00:00:00

abstract：:We hope to establish a new readmission prediction score for patients with head and neck cancer (HNC) after major cancer surgery. A retrospective cohort study was conducted from the clinical and cancer registry data at Kaohsiung Veterans General Hospital. We included the data of patients with newly diagnosed HNC who un...

journal_title：Oral oncology

authors： Yin CH,Kang BH,Liu WS,Pan LF,Chen HM,Lee CC

更新日期：2020-09-01 00:00:00

abstract：:Ameloblastoma is a rare human disease of benign neoplasm odontogenic tumor with a lower prevalence but higher recurrence rate. Etiology of ameloblastoma is not fully understood thus lacks implementation of curative treatments. One of the proposed models of evolution of ameloblastoma is related to alteration in DNA dam...

journal_title：Oral oncology

authors： Toprani SM

更新日期：2020-09-01 00:00:00

abstract：:Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smok...

journal_title：Oral oncology

authors： Kreimer AR,Chaturvedi AK,Alemany L,Anantharaman D,Bray F,Carrington M,Doorbar J,D'Souza G,Fakhry C,Ferris RL,Gillison M,Neil Hayes D,Hildesheim A,Huang SH,Kowalski LP,Lang Kuhs KA,Lewis J Jr,Lowy DR,Mehanna H,Ness A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The immune system is crucial in the evolution of head and neck cancer. Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic cells and immune cells in the tumor microenvironment. The main aim of this study was to apply univariate/multivariate analysis to investigate the p...

journal_title：Oral oncology

authors： Alessandrini L,Franz L,Ottaviano G,Ghi MG,Lanza C,Blandamura S,Marioni G

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Log odds of positive lymph nodes (LODDS) was reported to be significantly associated with prognosis in several malignant tumors. However, few are the studies on the correlation between LODDS and overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:A retrospective...

journal_title：Oral oncology

authors： Jin W,Zhu Z,Wu Y,Ding X,Wu H,Song X,Wu Y

更新日期：2020-09-01 00:00:00

abstract：:Intraosseous hemangioma is a benign vascular neoplasm and seldom affects the mandible. The diagnosis is challenging owing to its unspecific clinical and radiographic findings. Treatment options in children should be elective based on their age, symptoms, and facial deformity. Herein a rare case of intraosseous hemangi...

journal_title：Oral oncology

authors： Madiraju GS

更新日期：2020-09-01 00:00:00

abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

journal_title：Oral oncology

authors： Barlak N,Capik O,Sanli F,Karatas OF

更新日期：2020-08-19 00:00:00

abstract：BACKGROUND:Depth of invasion (DOI) has been introduced into the latest TNM classification of oral squamous cell carcinoma (OSCC). Despite its primarily pathological definition (pDOI), a preoperative evaluation of a radiological DOI (rDOI) would be useful but a standard and practical definition is lacking. The primary a...

journal_title：Oral oncology

authors： Locatello LG,Bruno C,Pietragalla M,Taverna C,Novelli L,Nardi C,Bonasera L,Cannavicci A,Maggiore G,Gallo O

更新日期：2020-08-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rou...

journal_title：Oral oncology

authors： Karmakar S,Kar A,Thakur S,Rao VUS

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...

journal_title：Oral oncology

authors： Fernandes DT,Prado-Ribeiro AC,Markman RL,Morais K,Moutinho K,Tonaki JO,Brandão TB,Rivera C,Santos-Silva AR,Lopes MA

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic...

journal_title：Oral oncology

authors： Liu C,Liao L,Wu G,Yan H,Chen X,Wang C,Zheng X,Zeng Z,Zhao Z,Wu D,Liu X

更新日期：2020-06-27 00:00:00

abstract：:Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection ...

journal_title：Oral oncology

authors： Borsetto D,Fussey J,Fabris L,Bandolin L,Gaudioso P,Phillips V,Polesel J,Boscolo-Rizzo P

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Reconstruction of the tongue and floor of mouth after total/subtotal glossectomy poses a major challenge for reconstructive surgeons. Speech and deglutition after total glossectomy are usually significantly impaired, affecting the quality of life of these patients. Maintaining an adequate volume of the recon...

journal_title：Oral oncology

authors： Ferrari M,Sahovaler A,Chan HHL,Nicolai P,Irish JC,Gilbert RW

更新日期：2020-06-01 00:00:00

abstract：:Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion >1 cm into l...

journal_title：Oral oncology

authors： Dhar H,Vaish R,D'Cruz AK

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate whether texture features extracted from 18F-FDG PET/CT images may provide additional prognostic information in patients with metastatic nasopharyngeal carcinoma (NPC). MATERIALS AND METHOD:We retrospectively examined 52 patients with metastatic NPC who underwent ass...

journal_title：Oral oncology

authors： Lin HC,Chan SC,Cheng NM,Liao CT,Hsu CL,Wang HM,Lin CY,Chang JT,Ng SH,Yang LY,Yen TC

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:There is currently no effective salvage therapeutic modality that improves the survival outcomes of patients with recurrent or metastatic nasopharyngeal carcinoma. However, the programmed cell death protein 1 (PD-1) and its ligand (PD-L1) inhibitors may provide clinical benefit for these advanced patients. ...

journal_title：Oral oncology

authors： Wang BC,Cao RB,Fu C,Chen WB,Li PD,Lin GH,Qian XJ,Li YT,Liu Q

更新日期：2020-05-01 00:00:00

abstract：:This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a...

journal_title：Oral oncology

authors： Mahajan A,Ahuja A,Sable N,Stambuk HE

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adenoid cystic carcinomas (ACC) are characterized by high rate of local recurrence and late distant metastasis. Chromosomal changes in the evolution from primary tumors to metastatic disease of ACC have not been appointed. Here we investigated the chromosomal alterations of 53 primary tumors from...

journal_title：Oral oncology

authors： Cordesmeyer R,Laskawi R,Schliephake H,Kauffmann P,Beck J,Bornemann-Kolatzki K,Schütz E,Ströbel P,Kueffer S,Fichtner A,Bremmer F

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS:Ret...

journal_title：Oral oncology

authors： Wang J,Tan Y,Shen Y,Lv M,Li J,Sun J

更新日期：2020-03-01 00:00:00

abstract：:Immunotherapy (IO) with anti-PD1 inhibitors is available for the treatment of recurrent/metastatic squamous cell carcinomas of the head and neck (SCCHD) since 2016. Both nivolumab and pembrolizumab were tested in phase 3 randomized trials in adults progressing on or after platinum-based therapy and were found to confe...

journal_title：Oral oncology

authors： Kokkali S,Ntokou A,Drizou M,Perdikari K,Makaronis P,Katsarou E,Koufopoulos N,Tzovaras A,Ardavanis A

更新日期：2020-02-01 00:00:00

abstract：:We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intratumoral (IT) PD-L1+ immune cells (ICs) or CD8+ infiltrating ICs are of prognostic value. Here we report the prognostic significance of these immune biomarkers in an independent validation c...

journal_title：Oral oncology

authors： Young RJ,Bressel M,Porceddu S,Cernelc J,Savas P,Liu H,Urban D,Thai AA,Cooper C,Fua T,Neeson P,Rischin D,Solomon B

更新日期：2020-02-01 00:00:00

abstract：:Tubulopapillary hidradenoma-like tumor of the mandible is extremely rare, with only 3 cases published in the English-language literature. The clinicopathological characteristics and histogenesis of this tumor are unclear. Few pathologists and perhaps fewer clinicians are familiar with this entity, and it is likely und...

journal_title：Oral oncology

authors： Zeng M,Guo X,Chen X,Yang S

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the role of the extended Abbé flap in the reconstruction of complex midfacial defects (upper lip, nasal base and medial cheek). We describe our personal experience with this method and present some interesting aspects from the relevant literature. MATERIALS AND METHO...

journal_title：Oral oncology

authors： Mantsopoulos K,Iro H,Constantinidis J

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:There exist no uniform decision criteria for conservative organ preservation treatments in head and neck cancer patients. Even with 18F-FDG-PET/CT after induction chemotherapy patient selection is challenging. This study correlated metabolic tumor response with treatment types and recurrence patterns. MATER...

journal_title：Oral oncology

authors： Semrau S,Schmidt D,Hecht M,Haderlein M,Kitzsteiner C,Müller S,Traxdorf M,Agaimy A,Iro H,Kuwert T,Fietkau R

更新日期：2020-01-01 00:00:00

abstract：IMPORTANCE:United States military personnel during the Vietnam Era were potentially exposed to Agent Orange, a known carcinogen. The link between Agent Orange and head and neck cancers is largely unknown; laryngeal cancer is currently the only subsite with sufficient evidence of an Agent Orange association. OBJECTIVE:...

journal_title：Oral oncology

authors： Mowery A,Conlin M,Clayburgh D

更新日期：2020-01-01 00:00:00