HCV infection and the risk of head and neck cancer: A meta-analysis.

Abstract:

:Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. For each cancer site, risk ratios from individual studies were displayed in forest plots; pooled risk ratios (RR) and corresponding confidence intervals (CI) were calculated. A significant association was found between HCV infection and cancers of the oral cavity (RR = 2.13; 95%: 1.61-2.83), oropharynx (RR = 1.81; 95% CI: 1.21-2.72), and larynx (RR = 2.57; 95% CI: 1.11-5.94). A similar picture emerged for hypopharyngeal cancer, though this result did not fully reach statistical significance because of the small number of available studies (RR = 2.15; 95% CI: 0.73-6.31). These findings remained similar after exclusion of patients with HIV co-infection. Our results highlighted the importance of surveillance of the upper aerodigestive tract in patients with known chronic HCV infections in order to enable HNSCC early diagnosis. In addition, they could be a reminder of the possibility of undiagnosed HCV infection to the clinicians treating HNSCC.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Borsetto D,Fussey J,Fabris L,Bandolin L,Gaudioso P,Phillips V,Polesel J,Boscolo-Rizzo P

doi

10.1016/j.oraloncology.2020.104869

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

104869

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(20)30305-5

journal_volume

109

pub_type

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