Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma.

abstract：OBJECTIVES:The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patient...

journal_title：Oral oncology

authors： Kramer FJ,Böhrnsen F,Moser N,Schliephake H

更新日期：2015-07-01 00:00:00

abstract：:The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dyspl...

journal_title：Oral oncology

authors： Kujan O,Oliver RJ,Khattab A,Roberts SA,Thakker N,Sloan P

更新日期：2006-11-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is often diagnosed at advanced stages and is associated with poor survival rates. Increasing evidence suggests that microRNAs (miRNAs) present in liquid biopsies could be potential biomarkers for non-invasive OSCC diagnosis. Here, we performed a comprehensive meta-analysis to evalua...

journal_title：Oral oncology

authors： Rapado-González O,Martínez-Reglero C,Salgado-Barreira A,López-López R,Suárez-Cunqueiro MM,Muinelo-Romay L

更新日期：2019-12-01 00:00:00

abstract：:Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

journal_title：Oral oncology

authors： Favia GF,Di Alberti L,Scarano A,Piattelli A

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:In carefully selected oral cavity cancers, marginal mandibulectomy is an adequate procedure which achieves good disease control adhering to the principle of "doing as little as possible and as much as necessary". METHODOLOGY:This was a retrospective study done by reviewing the medical records of all patient...

journal_title：Oral oncology

authors： Suresh S,Thomas S,Janardhan D,Patil S,George NA,Varghese BT,Iype EM,Rafi M,George CK

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:The submental artery island flap (SIF) has recently been described in temporal bone defects. At our institution we have broadened the application of the SIF and modified the harvest technique for complex lateral facial and skull base defects. Our primary aim is to evaluate the outcomes of patients undergoing...

journal_title：Oral oncology

authors： Patel AV,Thuener JE,Clancy K,Ascha M,Manzoor NF,Zender CA

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:There is currently no effective salvage therapeutic modality that improves the survival outcomes of patients with recurrent or metastatic nasopharyngeal carcinoma. However, the programmed cell death protein 1 (PD-1) and its ligand (PD-L1) inhibitors may provide clinical benefit for these advanced patients. ...

journal_title：Oral oncology

authors： Wang BC,Cao RB,Fu C,Chen WB,Li PD,Lin GH,Qian XJ,Li YT,Liu Q

更新日期：2020-05-01 00:00:00

abstract：:Quality of life evaluation is an important measure of outcome following the treatment of head and neck cancer. The aim of this study was to evaluate the quality of life of patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma. 50 consecutive patients with previously untreated oral canc...

journal_title：Oral oncology

authors： Rogers SN,Humphris G,Lowe D,Brown JS,Vaughan ED

更新日期：1998-05-01 00:00:00

abstract：:Comorbidity and diagnostic delay are independent prognostic factors in head and neck cancer, most notably in laryngeal cancer. We investigated their inter-relationship and their relative significance in survival of three different head and neck cancers. A population-based retrospective cohort of 221 patients with canc...

journal_title：Oral oncology

authors： Teppo H,Alho OP

更新日期：2009-08-01 00:00:00

abstract：:Early detection of oral cancer is crucial in improving survival rate. Identification and detection of oral potentially malignant disorders (OPMD) allow delivery of interventions to reduce the evolution of these disorders to malignancy. A variety of new and emerging diagnostic aids and adjunctive techniques are current...

journal_title：Oral oncology

authors： Awan KH,Morgan PR,Warnakulasuriya S

更新日期：2011-04-01 00:00:00

abstract：:Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for...

journal_title：Oral oncology

authors： Nurmenniemi S,Koivula MK,Nyberg P,Tervahartiala T,Sorsa T,Mattila PS,Salo T,Risteli J

更新日期：2012-02-01 00:00:00

abstract：:Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary SCC of the pharynx (oropharynx, n=11): see and hypopharynx, n=11) and larynx ( n=28) were examined for numerical aberrations of chromosomes 8, 9,...

journal_title：Oral oncology

authors： Hardisson D,Alvarez-Marcos C,Salas-Bustamante A,Alonso-Guervós M,Sastre N,Sampedro A

更新日期：2004-04-01 00:00:00

abstract：:Maxillary defects can be resolved by prosthetic obturation, autologous tissue reconstruction, or a combination of both. However, there is still controversy in the selection of the optimal approach. Therefore, the aim of this study was to systematically review evidences comparing the performance of obturators and flaps...

journal_title：Oral oncology

authors： Cao Y,Yu C,Liu W,Miao C,Han B,Yang J,Li L,Li C

更新日期：2018-07-01 00:00:00

abstract：:Integrins are a family of heterodimeric, cation-dependent cell membrane adhesion molecules which mediate cell-cell and cell-matrix interactions. They play a fundamental role in the maintenance of tissue integrity and in the regulation of cell proliferation, growth, differentiation and migration. It is not surprising, ...

journal_title：Oral oncology

authors： Thomas GJ,Jones J,Speight PM

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

journal_title：Oral oncology

authors： Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

更新日期：2016-08-01 00:00:00

abstract：:The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process an...

journal_title：Oral oncology

authors： Zolkind P,Dunn GP,Lin T,Griffith M,Griffith OL,Uppaluri R

更新日期：2017-08-01 00:00:00

abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

journal_title：Oral oncology

authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic...

journal_title：Oral oncology

authors： Liu C,Liao L,Wu G,Yan H,Chen X,Wang C,Zheng X,Zeng Z,Zhao Z,Wu D,Liu X

更新日期：2020-06-27 00:00:00

abstract：:Squamous cell carcinoma of the oral cavity (SCC) accounts for 3% of cancers in the western world and 40% of cancers in India. The overall 5-year survival rate is only 50%. Most of the lesions appear intra-orally on the tongue. Results from a previous study demonstrated a significant increase in T and B-lymphocytes und...

journal_title：Oral oncology

authors： Gannot G,Buchner A,Keisari Y

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...

journal_title：Oral oncology

authors： Tao X,Hill KS,Gaziova I,Sastry SK,Qui S,Szaniszlo P,Fennewald S,Resto VA,Elferink LA

更新日期：2014-02-01 00:00:00

abstract：:Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemothe...

journal_title：Oral oncology

authors： Retzbach EP,Sheehan SA,Nevel EM,Batra A,Phi T,Nguyen ATP,Kato Y,Baredes S,Fatahzadeh M,Shienbaum AJ,Goldberg GS

更新日期：2018-03-01 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Incidence rates increase with sun exposure and after immunosuppression and organ transplantation. A significant proportion of MCC have been reported to...

journal_title：Oral oncology

authors： Suárez C,Rodrigo JP,Ferlito A,Devaney KO,Rinaldo A

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...

journal_title：Oral oncology

authors： Philips R,Topf MC,Graf A,Krein H,Heffelfinger R,Luginbuhl A,Curry J

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS:A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 ...

journal_title：Oral oncology

authors： Liu SZ,Zandberg DP,Schumaker LM,Papadimitriou JC,Cullen KJ

更新日期：2015-09-01 00:00:00

abstract：:The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...

journal_title：Oral oncology

authors： Bloching M,Hofmann A,Lautenschläger C,Berghaus A,Grummt T

更新日期：2000-11-01 00:00:00

abstract：:The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....

journal_title：Oral oncology

authors： de Carvalho AC,Kowalski LP,Campos AH,Soares FA,Carvalho AL,Vettore AL

更新日期：2012-03-01 00:00:00

abstract：:Eosinophils are present in large numbers in some squamous cell carcinomas of the oral cavity. Whilst it is proposed that they have an 'immuno-protective' effect, this remains unproven. The contradictory reports may be due to inconsistencies in eosinophil counting. Eighty-one cases of squamous cell carcinoma (SSC) of o...

journal_title：Oral oncology

authors： Alkhabuli JO,High AS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

journal_title：Oral oncology

authors： Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

更新日期：2014-10-01 00:00:00

abstract：:We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a). Pleomorphic adenomas showed a pre...

journal_title：Oral oncology

authors： Hisatomi M,Asaumi J,Yanagi Y,Konouchi H,Matsuzaki H,Honda Y,Kishi K

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques. PATIENTS AND METHODS:We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-...

journal_title：Oral oncology

authors： Bedogni A,Bettini G,Bedogni G,Menapace G,Sandi A,Michelon F,Di Carlo R,Franco P,Saia G

更新日期：2021-01-01 00:00:00