Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.

abstract：OBJECTIVES:We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). METHODS:Eligible patients were randomly assigned to an intervention or control group. Patients in the ...

journal_title：Oral oncology

authors： Huang S,Piao Y,Cao C,Chen J,Sheng W,Shu Z,Hua Y,Jiang F,Hu Q,Chen X,Chen Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim ...

journal_title：Oral oncology

authors： Dong L,Ge XY,Wang YX,Yang LQ,Li SL,Yu GY,Gao Y,Fu J

更新日期：2013-11-01 00:00:00

abstract：:Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...

journal_title：Oral oncology

authors： Rêgo DF,Pavan LM,Elias ST,De Luca Canto G,Guerra EN

更新日期：2015-05-01 00:00:00

abstract：:Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary SCC of the pharynx (oropharynx, n=11): see and hypopharynx, n=11) and larynx ( n=28) were examined for numerical aberrations of chromosomes 8, 9,...

journal_title：Oral oncology

authors： Hardisson D,Alvarez-Marcos C,Salas-Bustamante A,Alonso-Guervós M,Sastre N,Sampedro A

更新日期：2004-04-01 00:00:00

abstract：:Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcino...

journal_title：Oral oncology

authors： Zhu Q,White FH,Tipoe GL

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution. PATIENTS AND METHODS:An Institutional Review Board (IRB)-approved...

journal_title：Oral oncology

authors： Gupta P,Migliacci JC,Montero PH,Zanoni DK,Shah JP,Patel SG,Ganly I

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The programmed death pathway plays a role in persistent human papillomavirus (HPV) infection as well as in resistance to immune elimination during malignant progression. In this study, we examined PD-L1 expression by immunohistochemistry and tumour infiltrating lymphocytes (TIL) in 214 patients with orophary...

journal_title：Oral oncology

authors： Hong AM,Ferguson P,Dodds T,Jones D,Li M,Yang J,Scolyer RA

更新日期：2019-05-01 00:00:00

abstract：:There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

journal_title：Oral oncology

authors： Davies AN,Broadley K,Beighton D

更新日期：2002-10-01 00:00:00

abstract：:Betel quid, cigarettes and alcohol are well-recognized risk factors for oral cancer. However, the combined effect of the frequency and duration of these oral habits on the risk for developing oral pre-malignancies among betel quid users has not been fully addressed. In this study, an oral screening programme for men c...

journal_title：Oral oncology

authors： Yen AM,Chen SC,Chen TH

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:After induction chemotherapy (IC) for laryngeal cancer, Computed Tomography (CT) is used to assess tumor response but lacks rationalized methods for measurement of this response. In T3 laryngeal cancer, remobilization of an initially fixed vocal cord (VC) is a major sign of tumor response. We compared the pe...

journal_title：Oral oncology

authors： Garcia GCTE,Gorphe P,Hartl D,Ammari S,Even C,Tao Y,Balleyguier C,Varoquaux A,Bidault F

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

journal_title：Oral oncology

authors： Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

更新日期：2017-05-01 00:00:00

abstract：:Carboplatin (CBDCA) alone or in combination with irradiation and other chemotherapeutic agents has been used for the treatment of oral squamous carcinoma. However, there are some limitations for such therapy because of inherent or acquired resistance to CBDCA. To gain some insights into the association of CBDCA resist...

journal_title：Oral oncology

authors： Noutomi T,Chiba H,Itoh M,Toyota H,Mizuguchi J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Head and neck mucosal melanoma (HNMM) is a rare and aggressive disease with a high metastatic potential. Two staging systems are currently available: one specific to HNMM (mmTNM) and one specific to primary tumour sites (sccTNM). Our main objective was to assess the prognostic value of both of these classifi...

journal_title：Oral oncology

authors： Moya-Plana A,Mangin D,Dercle L,Taouachi R,Casiraghi O,Ammari S,Nguyen F,Temam S,Robert C,Gorphe P

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...

journal_title：Oral oncology

authors： van Monsjou HS,Schaapveld M,Hamming-Vrieze O,de Boer JP,van den Brekel MW,Balm AJ

更新日期：2016-01-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：:In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol,...

journal_title：Oral oncology

authors： Jhavar S,Sarin R,Mulherkar R,Benner A,Agarwal JP,Dinshaw K

更新日期：2004-01-01 00:00:00

abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

journal_title：Oral oncology

authors： Barlak N,Capik O,Sanli F,Karatas OF

更新日期：2020-08-19 00:00:00

abstract：:Forty-four patients with head and neck malignancies were included in a prospective, randomized, double-blind, placebo-controlled study for evaluation of sucralfate in prevention of oral mucositis induced by radiation therapy. Patients were randomized to receive oral suspensions of either sucralfate (n = 23) or placebo...

journal_title：Oral oncology

authors： Etiz D,Erkal HS,Serin M,Küçük B,Hepari A,Elhan AH,Tulunay O,Cakmak A

更新日期：2000-01-01 00:00:00

abstract：:The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...

journal_title：Oral oncology

authors： Chen MK,Chiou HL,Su SC,Chung TT,Tseng HC,Tsai HT,Yang SF

更新日期：2009-12-01 00:00:00

abstract：:We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a). Pleomorphic adenomas showed a pre...

journal_title：Oral oncology

authors： Hisatomi M,Asaumi J,Yanagi Y,Konouchi H,Matsuzaki H,Honda Y,Kishi K

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS:A retrospective ...

journal_title：Oral oncology

authors： Dziegielewski PT,Reschly WJ,Morris CG,DeJesus RD,Silver N,Boyce BJ,Santiago I 3rd,Amdur RJ,Mendenhall WM

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

journal_title：Oral oncology

authors： Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Current guidelines recommend chest computed tomography (CT) with locoregional CT/magnetic resonance imaging for patients with head and neck squamous cell carcinoma (HNSCC), and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT is suggested for stage III-IV patients. However, whole body scree...

journal_title：Oral oncology

authors： Kim Y,Roh JL,Kim JS,Lee JH,Choi SH,Nam SY,Kim SY

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...

journal_title：Oral oncology

authors： Antunes HS,Schluckebier LF,Herchenhorn D,Small IA,Araújo CM,Viégas CM,Rampini MP,Ferreira EM,Dias FL,Teich V,Teich N,Ferreira CG

更新日期：2016-01-01 00:00:00

abstract：:p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...

journal_title：Oral oncology

authors： Agarwal S,Mathur M,Shukla NK,Ralhan R

更新日期：1998-09-01 00:00:00

abstract：:Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

journal_title：Oral oncology

authors： Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

journal_title：Oral oncology

authors： de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

更新日期：2013-06-01 00:00:00

abstract：:Recently, we reported the preliminary results of a prospective study on the possible premalignant character of oral lichen planus (OLP) and oral lichenoid lesions (OLL). Based on these data it was concluded that there was some but no convincing support for the hypothesis that patients with OLL have an increased risk o...

journal_title：Oral oncology

authors： van der Meij EH,Mast H,van der Waal I

更新日期：2007-09-01 00:00:00

abstract：:The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...

journal_title：Oral oncology

authors： Hindle I,Downer MC,Moles DR,Speight PM

更新日期：2000-07-01 00:00:00

abstract：:Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/Pu...

journal_title：Oral oncology

authors： Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AF

更新日期：2017-09-01 00:00:00