Podoplanin expression in oral leukoplakia: tumorigenic role.


OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia. MATERIALS AND METHODS:In this retrospective study, podoplanin immunoexpression was analyzed in 58 patients with oral leukoplakia that showed epithelial dysplasia. Lesions with podoplanin expression in the basal and suprabasal layers of oral epithelium at one area or showing suprabasal expression at two or more areas were considered as positive. Association between podoplanin expression and oral cancer development was analyzed. RESULTS:Twenty-two of the 58 lesions (38%) were classified as podoplanin-positive, and the remaining 36 (62%) lesions were considered podoplanin-negative. The expression of podoplanin was correlated with the grade of dysplasia (p<0.0005), and with the risk of progression to oral cancer (p<0.0005). In multivariate survival analysis, only premalignant oral lesions displaying positive podoplanin expression showed a significantly increased risk of developing an oral squamous cell carcinoma (hazard ratio=8.738, p=0.007). CONCLUSION:Podoplanin could be a valuable biomarker for risk assessment of malignant transformation in patients with OPL along with histological assessment.


Oral Oncol


Oral oncology


de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM




Has Abstract


2013-06-01 00:00:00














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    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Chiang AK,Mak NK,Ng WT

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    authors: Awan KH,Morgan PR,Warnakulasuriya S

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  • Malignant melanoma of the oral cavity: diagnosis and treatment experience in a Mexican population.

    abstract::Oral malignant melanoma is uncommon, accounting for 1-8% of all malignant melanomas. All previous papers have reported small numbers of cases or have retrospectively reviewed case reports from the literature. The following case reports concern malignant melanoma of the oral cavity seen at the Instituto Nacional de Can...

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    authors: Lopez-Graniel CM,Ochoa-Carrillo FJ,Meneses-García A

    更新日期:1999-07-01 00:00:00

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    abstract::Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

    journal_title:Oral oncology

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    authors: Bernstein JM,Homer JJ,West CM

    更新日期:2014-10-01 00:00:00

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    abstract:OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

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    authors: Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

    更新日期:2017-05-01 00:00:00

  • Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.

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    journal_title:Oral oncology

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    authors: Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

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    pub_type: 杂志文章


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    更新日期:2018-04-01 00:00:00

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    更新日期:2019-01-01 00:00:00

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    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Retzbach EP,Sheehan SA,Nevel EM,Batra A,Phi T,Nguyen ATP,Kato Y,Baredes S,Fatahzadeh M,Shienbaum AJ,Goldberg GS

    更新日期:2018-03-01 00:00:00

  • Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

    abstract:INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...

    journal_title:Oral oncology

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    authors: Wolf GT,Winter W,Bellile E,Nguyen A,Donnelly CR,McHugh JB,Thomas D,Amlani L,Rozek L,Lei YL,Head and Neck SPORE Program.

    更新日期:2018-12-01 00:00:00

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    abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

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    authors: Favia GF,Di Alberti L,Scarano A,Piattelli A

    更新日期:1997-11-01 00:00:00

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    authors: Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

    更新日期:2015-11-01 00:00:00

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    abstract::Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/Pu...

    journal_title:Oral oncology

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    authors: Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AF

    更新日期:2017-09-01 00:00:00

  • The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy.

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    pub_type: 杂志文章,评审


    authors: Andersson MK,Stenman G

    更新日期:2016-06-01 00:00:00

  • Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay.

    abstract:OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

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    authors: Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

    更新日期:2014-06-01 00:00:00

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    abstract::The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Sun Q,Nawabi-Ghasimi F,Basile JR

    更新日期:2008-06-01 00:00:00

  • Hypoxia modulates CCR7 expression in head and neck cancers.

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    authors: Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

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  • Role of adjuvant chemotherapy in malignant mucosal melanoma of the head and neck.

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    更新日期:2010-08-01 00:00:00

  • The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma. Is there really evidence for a change?

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    pub_type: 杂志文章


    authors: Kurihara K,Tajima Y,Kawasaki M,Ueha T

    更新日期:1999-07-01 00:00:00

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    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

    更新日期:2019-03-01 00:00:00

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    journal_title:Oral oncology

    pub_type: 杂志文章


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    更新日期:2017-06-01 00:00:00

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    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lee DH,Kim SY,Nam SY,Choi SH,Choi JW,Roh JL

    更新日期:2011-06-01 00:00:00