Abstract：
OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia. MATERIALS AND METHODS:In this retrospective study, podoplanin immunoexpression was analyzed in 58 patients with oral leukoplakia that showed epithelial dysplasia. Lesions with podoplanin expression in the basal and suprabasal layers of oral epithelium at one area or showing suprabasal expression at two or more areas were considered as positive. Association between podoplanin expression and oral cancer development was analyzed. RESULTS:Twenty-two of the 58 lesions (38%) were classified as podoplanin-positive, and the remaining 36 (62%) lesions were considered podoplanin-negative. The expression of podoplanin was correlated with the grade of dysplasia (p<0.0005), and with the risk of progression to oral cancer (p<0.0005). In multivariate survival analysis, only premalignant oral lesions displaying positive podoplanin expression showed a significantly increased risk of developing an oral squamous cell carcinoma (hazard ratio=8.738, p=0.007). CONCLUSION:Podoplanin could be a valuable biomarker for risk assessment of malignant transformation in patients with OPL along with histological assessment.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JMdoi
10.1016/j.oraloncology.2013.02.008subject
Has Abstractpub_date
2013-06-01 00:00:00pages
598-603issue
6eissn
1368-8375issn
1879-0593pii
S1368-8375(13)00040-7journal_volume
49pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract：:Our aim of the study was to investigate the precise relationship of repair cross-complementation group 1 (ERCC1) expression and the survival as well as objective response rate to cisplatin-based concurrent chemoradiotherapy (CCRT) and a meta-analysis was conducted to analysis ERCC1's prognostic roles in head and neck ...
journal_title：Oral oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.oraloncology.2015.03.009
更新日期：2015-06-01 00:00:00
abstract：:Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2007.02.003
更新日期：2008-03-01 00:00:00
abstract：:Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional coactivators, tyrosine kin...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2016.04.002
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS:Ret...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.104507
更新日期：2020-03-01 00:00:00
abstract：:Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.09.008
更新日期：2017-11-01 00:00:00
abstract：:The present study sought to determine the potential role of stress activated MAPK and phosphatidylinositol 3-kinase (PI3K) signaling pathways in mediating phenotypic switching between angiogenic and angiostatic elements among squamous cell carcinoma (SCC) cell lines. In particular, we investigated the effects of hypox...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(03)00110-6
更新日期：2003-12-01 00:00:00
abstract：:We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s1368-8375(00)00068-3
更新日期：2001-04-01 00:00:00
abstract：:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.12.008
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.04.011
更新日期：2019-06-01 00:00:00
abstract：:Immunotherapy (IO) with anti-PD1 inhibitors is available for the treatment of recurrent/metastatic squamous cell carcinomas of the head and neck (SCCHD) since 2016. Both nivolumab and pembrolizumab were tested in phase 3 randomized trials in adults progressing on or after platinum-based therapy and were found to confe...
journal_title：Oral oncology
pub_type： 信件
doi：10.1016/j.oraloncology.2019.07.002
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:To investigate the incidence and clinical features of post-radiation nasopharyngeal necrosis (PRNN), and effectiveness of surgical intervention for its treatment. MATERIALS AND METHODS:Retrospectively, we reviewed 380 NPC patients who underwent high dose radiotherapy (RT) (single RT in 355 and re-RT in 25) fro...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2021.105180
更新日期：2021-01-23 00:00:00
abstract：OBJECTIVES:Prior studies suggest that oxaliplatin is unique among platinum chemotherapy drugs in its ability to enhance anti-tumor immunity, but the immune mechanisms of different platinum chemotherapy drugs have not been previously compared in preclinical models of head and neck squamous cell carcinoma (HNSCC). MATER...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.06.016
更新日期：2019-08-01 00:00:00
abstract：:Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in...
journal_title：Oral oncology
pub_type： 信件,评审
doi：10.1016/j.oraloncology.2018.12.013
更新日期：2019-03-01 00:00:00
abstract：:The etiology of oral squamous cell carcinoma has been linked to environmental carcinogens, such as activated aromatic heterocyclic radicals and epoxides. Our previous work on implantable and 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer showed that oral glutamine (GLN) inhibited tumor growth possibly thr...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2008.04.008
更新日期：2009-02-01 00:00:00
abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.11.010
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2015.10.013
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:In shared decision making it is important to adequately, timely and actively involve patients in treatment decisions. Sharing prognostic information can be of key importance. This study describes whether and how prognostic information on life expectancy is included during communication on diagnosis and treat...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.07.014
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.09.023
更新日期：2019-11-01 00:00:00
abstract：:Cell lines developed from head and neck squamous cell carcinomas exhibit variable responses to the negative regulatory effects of transforming growth factor beta (TGF beta) on cell growth. To analyse the effects of TGF beta on regulators of cell cycle progression, we characterised cell lines derived from head and neck...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(97)00023-7
更新日期：1998-01-01 00:00:00
abstract：:Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2015.01.007
更新日期：2015-05-01 00:00:00
abstract：:Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment of murine OSCC cell lines and syngeneic mode...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.06.026
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Histopathological grading of adenoid cystic carcinoma (ACC) is a controversial issue. It is generally agreed that solid type ACC has a relatively poor prognosis. However, the amount of solid regions within this often mixed type tumor that predicts a poor prognosis is not firmly established. Some authors stip...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.10.007
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:To evaluate a single-institutional experience with the use of re-irradiation for recurrent and new primary cancers of the head and neck. METHODS:The medical charts of 80 consecutive patients who underwent re-irradiation for local-regionally recurrent or second primary head and neck cancer between November 1998...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.01.007
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Surgical management of patients following zoledronic acid therapy is particularly difficult, since the dental extraction is the main cause of BRONJ. METHODS:A case-control study was conducted on 176 patients treated with intravenous (IV) bisphosphonates for oncologic pathologies who also underwent dental ex...
journal_title：Oral oncology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.oraloncology.2012.03.009
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVES:Healthy life expectancy, an extension of the concept of life expectancy, is a summary measure of population health that takes into account the mortality and morbidity of a population. The aim of the present study was to retrospectively analyze the self-reliance survival times of oral squamous cell carcinoma ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.11.014
更新日期：2017-01-01 00:00:00
abstract：:The present study was conducted to evaluate the therapeutic results of alternating chemoradiotherapy for locally advanced nasopharyngeal cancer. The subjects were 87 patients with stage II-IVB nasopharyngeal cancer. Alternating chemoradiotherapy was performed; initially, chemotherapy was administered, and then radioth...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2006.11.003
更新日期：2007-10-01 00:00:00
abstract：:Sarcomas developing after radiation treatment for primary malignancies of the head and neck are often detected clinically when they are very aggressive. We reviewed the patient demographics and imaging findings in 21 patients with radiation-associated sarcomas (RAS) of the head and neck treated at our institution. Twe...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.08.017
更新日期：2012-02-01 00:00:00
abstract：:Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies t...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s0964-1955(96)00064-4
更新日期：1997-05-01 00:00:00
abstract：:In our previous study, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including a human immortalized oral epithelial cell (HIOEC) and a cancerous cell line (HB96). Microarray analysis showed that the gene encoding Yes-associated protein (YAP) was significantly increase...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.06.003
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:Head and neck cancer patients and their caregivers report high rates of psychological distress. High rates of physical symptom burden and the increased need for family members to provide caregiving during treatment may contribute to this distress. METHODS:This study examined trajectories of patient and care...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.07.003
更新日期：2014-10-01 00:00:00
