Podoplanin expression in oral leukoplakia: tumorigenic role.

Abstract:

OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia. MATERIALS AND METHODS:In this retrospective study, podoplanin immunoexpression was analyzed in 58 patients with oral leukoplakia that showed epithelial dysplasia. Lesions with podoplanin expression in the basal and suprabasal layers of oral epithelium at one area or showing suprabasal expression at two or more areas were considered as positive. Association between podoplanin expression and oral cancer development was analyzed. RESULTS:Twenty-two of the 58 lesions (38%) were classified as podoplanin-positive, and the remaining 36 (62%) lesions were considered podoplanin-negative. The expression of podoplanin was correlated with the grade of dysplasia (p<0.0005), and with the risk of progression to oral cancer (p<0.0005). In multivariate survival analysis, only premalignant oral lesions displaying positive podoplanin expression showed a significantly increased risk of developing an oral squamous cell carcinoma (hazard ratio=8.738, p=0.007). CONCLUSION:Podoplanin could be a valuable biomarker for risk assessment of malignant transformation in patients with OPL along with histological assessment.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

doi

10.1016/j.oraloncology.2013.02.008

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

598-603

issue

6

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(13)00040-7

journal_volume

49

pub_type

杂志文章
  • Translational research in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2013.11.005

    authors: Chiang AK,Mak NK,Ng WT

    更新日期:2014-05-01 00:00:00

  • Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign keratoses.

    abstract::Early detection of oral cancer is crucial in improving survival rate. Identification and detection of oral potentially malignant disorders (OPMD) allow delivery of interventions to reduce the evolution of these disorders to malignancy. A variety of new and emerging diagnostic aids and adjunctive techniques are current...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.02.001

    authors: Awan KH,Morgan PR,Warnakulasuriya S

    更新日期:2011-04-01 00:00:00

  • Malignant melanoma of the oral cavity: diagnosis and treatment experience in a Mexican population.

    abstract::Oral malignant melanoma is uncommon, accounting for 1-8% of all malignant melanomas. All previous papers have reported small numbers of cases or have retrospectively reviewed case reports from the literature. The following case reports concern malignant melanoma of the oral cavity seen at the Instituto Nacional de Can...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(99)00017-2

    authors: Lopez-Graniel CM,Ochoa-Carrillo FJ,Meneses-García A

    更新日期:1999-07-01 00:00:00

  • Dynamic contrast-enhanced magnetic resonance imaging biomarkers in head and neck cancer: potential to guide treatment? A systematic review.

    abstract::Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2014.07.011

    authors: Bernstein JM,Homer JJ,West CM

    更新日期:2014-10-01 00:00:00

  • Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.

    abstract:OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.03.006

    authors: Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

    更新日期:2017-05-01 00:00:00

  • Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.

    abstract::The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2007.11.008

    authors: Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

    更新日期:2008-09-01 00:00:00

  • Tumor volume as a predictor of survival in T3 glottic carcinoma: A novel approach to patient selection.

    abstract:BACKGROUND:The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS:A retrospective ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.02.015

    authors: Dziegielewski PT,Reschly WJ,Morris CG,DeJesus RD,Silver N,Boyce BJ,Santiago I 3rd,Amdur RJ,Mendenhall WM

    更新日期:2018-04-01 00:00:00

  • From reactive to proactive tube feeding during chemoradiotherapy for head and neck cancer: A clinical prediction model-based approach.

    abstract:OBJECTIVES:Feeding tubes are placed unnecessarily in a proportion of head and neck cancer (HNC) patients treated with chemoradiotherapy (CRT) when prophylactic tube placement protocols are used. This may have a negative impact on the risk of long-term dysphagia. Reactive tube placement protocols, on the other hand, mig...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.11.031

    authors: Karsten RT,Stuiver MM,van der Molen L,Navran A,de Boer JP,Hilgers FJM,Klop WMC,Smeele LE

    更新日期:2019-01-01 00:00:00

  • Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target.

    abstract::Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemothe...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2018.01.011

    authors: Retzbach EP,Sheehan SA,Nevel EM,Batra A,Phi T,Nguyen ATP,Kato Y,Baredes S,Fatahzadeh M,Shienbaum AJ,Goldberg GS

    更新日期:2018-03-01 00:00:00

  • Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

    abstract:INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.10.010

    authors: Wolf GT,Winter W,Bellile E,Nguyen A,Donnelly CR,McHugh JB,Thomas D,Amlani L,Rozek L,Lei YL,Head and Neck SPORE Program.

    更新日期:2018-12-01 00:00:00

  • Clinical features of post-radiation nasopharyngeal necrosis and their outcomes following surgical intervention in nasopharyngeal cancer patients.

    abstract:PURPOSE:To investigate the incidence and clinical features of post-radiation nasopharyngeal necrosis (PRNN), and effectiveness of surgical intervention for its treatment. MATERIALS AND METHODS:Retrospectively, we reviewed 380 NPC patients who underwent high dose radiotherapy (RT) (single RT in 355 and re-RT in 25) fro...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2021.105180

    authors: Yang K,Ahn YC,Nam H,Hong SD,Oh D,Noh JM

    更新日期:2021-01-23 00:00:00

  • Ameloblastic fibro-odontoma: report of two cases.

    abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s0964-1955(97)00046-8

    authors: Favia GF,Di Alberti L,Scarano A,Piattelli A

    更新日期:1997-11-01 00:00:00

  • Pre-treatment tumor-specific growth rate as a temporal biomarker that predicts treatment failure and improves risk stratification for oropharyngeal cancer.

    abstract:PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.09.001

    authors: Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

    更新日期:2015-11-01 00:00:00

  • Potential role of autofluorescence imaging in determining biopsy of oral potentially malignant disorders: A large prospective diagnostic study.

    abstract::Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome asse...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.08.006

    authors: Shi L,Li C,Shen X,Zhou Z,Liu W,Tang G

    更新日期:2019-11-01 00:00:00

  • Prognostic biomarkers in oral squamous cell carcinoma: A systematic review.

    abstract::Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/Pu...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2017.07.003

    authors: Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AF

    更新日期:2017-09-01 00:00:00

  • The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy.

    abstract::Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional coactivators, tyrosine kin...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2016.04.002

    authors: Andersson MK,Stenman G

    更新日期:2016-06-01 00:00:00

  • Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay.

    abstract:OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2014.02.011

    authors: Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

    更新日期:2014-06-01 00:00:00

  • Semaphorins in vascular development and head and neck squamous cell carcinoma-induced angiogenesis.

    abstract::The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2007.10.005

    authors: Sun Q,Nawabi-Ghasimi F,Basile JR

    更新日期:2008-06-01 00:00:00

  • Hypoxia modulates CCR7 expression in head and neck cancers.

    abstract:BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.03.014

    authors: Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

    更新日期:2018-05-01 00:00:00

  • Reconstruction design before tumour resection: A new concept of through-and-through cheek defect reconstruction.

    abstract:OBJECTIVE:To explore a new method of reconstruction of through-and-through cheek defects and to evaluate this method's efficacy and patient prognosis. MATERIALS AND METHODS:This retrospective study included 70 patients who underwent reconstruction of through-and-through cheek defects. The surgical approach, design of ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.09.023

    authors: Gong ZJ,Ren ZH,Wang K,Tan HY,Zhang S,Wu HJ

    更新日期:2017-11-01 00:00:00

  • Metabolic tumor volume of metastatic lymph nodes and survival after total laryngectomy in laryngeal and hypopharyngeal cancer.

    abstract:OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.04.011

    authors: Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

    更新日期:2019-06-01 00:00:00

  • Role of adjuvant chemotherapy in malignant mucosal melanoma of the head and neck.

    abstract::The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopatholog...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.05.005

    authors: Ahn HJ,Na II,Park YH,Cho SY,Lee BC,Lee GH,Koh JS,Lee YS,Shim YS,Kim YK,Kang HJ,Ryoo BY,Yang SH

    更新日期:2010-08-01 00:00:00

  • The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma. Is there really evidence for a change?

    abstract:BACKGROUND:Several recent studies have shown that incidence of oropharyngeal carcinomas is rising in the Western World. This increase has been attributed to changes in the etiology of oropharyngeal carcinomas with a growing role for infections with Human Papilloma viruses. This nationwide study evaluates and compares t...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.06.011

    authors: van Monsjou HS,Schaapveld M,van den Brekel MW,Balm AJ

    更新日期:2015-10-01 00:00:00

  • Unilateral endoscopic resection with transnasal craniectomy for sinonasal intestinal-type adenocarcinoma: A bi-institutional case-control study on 54 patients.

    abstract:OBJECTIVES:Intestinal-type adenocarcinoma (ITAC) of the ethmoid mostly affects patients exposed to wood dust and has been traditionally treated with bilateral resection. The aim of the present study was to validate unilateral endoscopic resection with transnasal craniectomy (uERTC) in selected ITACs. MATERIALS AND MET...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.oraloncology.2018.10.027

    authors: Schreiber A,Ferrari M,Mattavelli D,Rampinelli V,Taboni S,Vural A,Bignami M,Castelnuovo P,Nicolai P

    更新日期:2018-12-01 00:00:00

  • Cost-effectiveness analysis of the oral cancer screening program in Taiwan.

    abstract:OBJECTIVES:We assess the incremental cost-effectiveness ratio (ICER) of the oral cancer (OC) screening program in Taiwan. MATERIALS AND METHODS:We interlinked the Cancer Registry, Mortality Registry, National Vital Statistics, reimbursement database of National Health Insurance, and the National Oral Cancer Screening ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.12.011

    authors: Huang CC,Lin CN,Chung CH,Hwang JS,Tsai ST,Wang JD

    更新日期:2019-02-01 00:00:00

  • Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission.

    abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to inve...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.07.032

    authors: Cheng YS,Rees T,Jordan L,Oxford L,O'Brien J,Chen HS,Wong D

    更新日期:2011-12-01 00:00:00

  • Modulation of thyroid hormone-dependent Na+,K(+)-ATPase induction in cultured human submandibular gland cell lines, HSG cells.

    abstract::The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(98)00124-9

    authors: Kurihara K,Tajima Y,Kawasaki M,Ueha T

    更新日期:1999-07-01 00:00:00

  • Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

    abstract:BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.02.006

    authors: El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

    更新日期:2019-03-01 00:00:00

  • Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.

    abstract:OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.04.003

    authors: Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

    更新日期:2017-06-01 00:00:00

  • Risk factors of surgical site infection in patients undergoing major oncological surgery for head and neck cancer.

    abstract::We assessed the risk factors associated with surgical site infection (SSI) in 697 patients who underwent major oncological surgery for head-and-neck cancer (HNC). SSIs within 30days were classified as incision, space, or leakage/fistula. Preoperative and operative risk factors for SSIs were assessed by univariate and ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.04.002

    authors: Lee DH,Kim SY,Nam SY,Choi SH,Choi JW,Roh JL

    更新日期:2011-06-01 00:00:00