Podoplanin expression in oral leukoplakia: tumorigenic role.


OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelial dysplasia. MATERIALS AND METHODS:In this retrospective study, podoplanin immunoexpression was analyzed in 58 patients with oral leukoplakia that showed epithelial dysplasia. Lesions with podoplanin expression in the basal and suprabasal layers of oral epithelium at one area or showing suprabasal expression at two or more areas were considered as positive. Association between podoplanin expression and oral cancer development was analyzed. RESULTS:Twenty-two of the 58 lesions (38%) were classified as podoplanin-positive, and the remaining 36 (62%) lesions were considered podoplanin-negative. The expression of podoplanin was correlated with the grade of dysplasia (p<0.0005), and with the risk of progression to oral cancer (p<0.0005). In multivariate survival analysis, only premalignant oral lesions displaying positive podoplanin expression showed a significantly increased risk of developing an oral squamous cell carcinoma (hazard ratio=8.738, p=0.007). CONCLUSION:Podoplanin could be a valuable biomarker for risk assessment of malignant transformation in patients with OPL along with histological assessment.


Oral Oncol


Oral oncology


de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM




Has Abstract


2013-06-01 00:00:00














  • Is alcohol responsible for more intra-oral cancer?

    abstract::The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Hindle I,Downer MC,Moles DR,Speight PM

    更新日期:2000-07-01 00:00:00

  • Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.

    abstract:OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Saeed AA,Sims AH,Prime SS,Paterson I,Murray PG,Lopes VR

    更新日期:2015-03-01 00:00:00

  • miR-29b suppresses proliferation, migration, and invasion of tongue squamous cell carcinoma through PTEN-AKT signaling pathway by targeting Sp1.

    abstract:OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Jia LF,Huang YP,Zheng YF,Lyu MY,Wei SB,Meng Z,Gan YH

    更新日期:2014-11-01 00:00:00

  • Individualized treatment in stage IVC nasopharyngeal carcinoma.

    abstract::The stage IVC nasopharyngeal carcinoma is a catch-all entity covering minute solitary metastasis to bulky disseminated disease. Prognosis varies greatly within this stage group. A subset of patients with oligometastases may benefit from aggressive local ablative therapy. Meanwhile, in multiple metastatic diseases, cus...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Chan OS,Ngan RK

    更新日期:2014-09-01 00:00:00

  • Association between oral leukoplakia and upper gastrointestinal cancers: a 28-year follow-up study in the Linxian General Population Trial.

    abstract:BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

    更新日期:2014-10-01 00:00:00

  • Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer.

    abstract::Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

    更新日期:2006-05-01 00:00:00

  • Tube feeding during treatment for head and neck cancer - Adherence and patient reported barriers.

    abstract:OBJECTIVES:The main aim was to investigate the incidence of patient adherence to nutritional tube feeding recommendations in patients with head and neck cancer and to determine patient barriers to meeting tube feeding prescription. MATERIALS AND METHODS:This was an observational study from a randomised controlled tria...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Brown T,Banks M,Hughes BGM,Lin C,Kenny L,Bauer J

    更新日期:2017-09-01 00:00:00

  • Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head & neck cancer - a systematic review.

    abstract:PURPOSE:A systematic review to establish what evidence is available for swallowing outcomes following IMRT for head and neck cancer. METHODS:Online electronic databases were searched to identify papers published in English from January 1998 to December 2009. Papers were independently appraised by two reviewers for met...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Roe JW,Carding PN,Dwivedi RC,Kazi RA,Rhys-Evans PH,Harrington KJ,Nutting CM

    更新日期:2010-10-01 00:00:00

  • Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil--a phase II study.

    abstract::The present study was conducted to evaluate the therapeutic results of alternating chemoradiotherapy for locally advanced nasopharyngeal cancer. The subjects were 87 patients with stage II-IVB nasopharyngeal cancer. Alternating chemoradiotherapy was performed; initially, chemotherapy was administered, and then radioth...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fuwa N,Shikama N,Hayashi N,Matsuzuka T,Toita T,Yuta A,Oonishi H,Kodaira T,Tachibana H,Nakamura T,Daimon T

    更新日期:2007-10-01 00:00:00

  • Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma.

    abstract::Vascular endothelial growth factor (VEGF) A is known to play an important role in tumor angiogenesis. The additional members of the VEGF family, VEGF B, C and D have been discovered. VEGF C and D show some selectivity toward lymphatic endothelial cells. However, whether VEGF family members play a role in tumor angioge...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Shintani S,Li C,Ishikawa T,Mihara M,Nakashiro K,Hamakawa H

    更新日期:2004-01-01 00:00:00

  • Apoptosis, proliferation and p12(doc-1) profiles in normal, dysplastic and malignant squamous epithelium of the Syrian hamster cheek pouch model.

    abstract::Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) exp...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kohno Y,Patel V,Kim Y,Tsuji T,Chin BR,Sun M,Bruce Donoff R,Kent R,Wong D,Todd R

    更新日期:2002-04-01 00:00:00

  • Tumor volume as a predictor of survival in T3 glottic carcinoma: A novel approach to patient selection.

    abstract:BACKGROUND:The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS:A retrospective ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Dziegielewski PT,Reschly WJ,Morris CG,DeJesus RD,Silver N,Boyce BJ,Santiago I 3rd,Amdur RJ,Mendenhall WM

    更新日期:2018-04-01 00:00:00

  • Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study.

    abstract::EGFR overexpression in salivary gland carcinomas provides the rational for the investigation of anti-EGFR treatments in recurrent and/or metastatic salivary gland cancers (RMSGCs). The activity of cetuximab in terms of clinical benefit rate (CBR) defined as the occurrence of objective response (CR or PR) or stable dis...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Locati LD,Bossi P,Perrone F,Potepan P,Crippa F,Mariani L,Casieri P,Orsenigo M,Losa M,Bergamini C,Liberatoscioli C,Quattrone P,Calderone RG,Rinaldi G,Pilotti S,Licitra L

    更新日期:2009-07-01 00:00:00

  • Nivolumab in patients with rare head and neck carcinomas: A single center's experience.

    abstract::Immunotherapy (IO) with anti-PD1 inhibitors is available for the treatment of recurrent/metastatic squamous cell carcinomas of the head and neck (SCCHD) since 2016. Both nivolumab and pembrolizumab were tested in phase 3 randomized trials in adults progressing on or after platinum-based therapy and were found to confe...

    journal_title:Oral oncology

    pub_type: 信件


    authors: Kokkali S,Ntokou A,Drizou M,Perdikari K,Makaronis P,Katsarou E,Koufopoulos N,Tzovaras A,Ardavanis A

    更新日期:2020-02-01 00:00:00

  • Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.

    abstract::The present investigation has examined the clinical benefits of tobramycin, polymyxin E and amphotericin therapy in the management of oral mucositis in children undergoing chemotherapy prior to bone marrow transplantation. Tobramycin, polymyxin E, and amphotericin reduced the degree of oral mucositis more than convent...

    journal_title:Oral oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bondi E,Baroni C,Prete A,Gatti M,Carrassi A,Lodi G,Porter SR

    更新日期:1997-09-01 00:00:00

  • Increased risk of head and neck cancer in Agent Orange exposed Vietnam Era veterans.

    abstract:IMPORTANCE:United States military personnel during the Vietnam Era were potentially exposed to Agent Orange, a known carcinogen. The link between Agent Orange and head and neck cancers is largely unknown; laryngeal cancer is currently the only subsite with sufficient evidence of an Agent Orange association. OBJECTIVE:...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Mowery A,Conlin M,Clayburgh D

    更新日期:2020-01-01 00:00:00

  • Gene expression profiling by DNA microarrays and its application to dental research.

    abstract:UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TK

    更新日期:2002-10-01 00:00:00

  • Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment.

    abstract:BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fujiwara RJT,Burtness B,Husain ZA,Judson BL,Bhatia A,Sasaki CT,Yarbrough WG,Mehra S

    更新日期:2017-08-01 00:00:00

  • New insights into p53 protein stabilisation in oral squamous cell carcinoma.

    abstract::p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Partridge M,Kiguwa S,Emilion G,Pateromichelakis S,A'Hern R,Langdon JD

    更新日期:1999-01-01 00:00:00

  • Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.

    abstract::The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

    更新日期:2008-09-01 00:00:00

  • Sentinel lymph node biopsy in clinically N0 T1-T2 staged oral cancer: the Dutch multicenter trial.

    abstract:OBJECTIVES:Results of the Dutch multi-institutional trial on sentinel lymph node (SLN) biopsy in oral cancer. PATIENTS AND METHODS:Patients were consecutively enrolled from 4 institutions, with T1/T2 oral cancer and cN0 neck based on palpation and ultrasound guided fine needle aspiration cytology. Lymphatic mapping co...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Flach GB,Bloemena E,Klop WM,van Es RJ,Schepman KP,Hoekstra OS,Castelijns JA,Leemans CR,de Bree R

    更新日期:2014-10-01 00:00:00

  • Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1.

    abstract:OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

    更新日期:2015-12-01 00:00:00

  • The role of vascular endothelial growth factor (VEGF) in oral dysplasia and oral squamous cell carcinoma.

    abstract::A better understanding of oral cancer pathogenesis is essential to improving patient prognosis and treatment modalities. Research has shown a significant increase in vascularity during the transition from normal oral mucosa, through differing degrees of dysplasia, to invasive carcinoma. A close association between tum...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Johnstone S,Logan RM

    更新日期:2006-04-01 00:00:00

  • Elective versus therapeutic neck dissection in node-negative oral cancer: Evidence from five randomized controlled trials.

    abstract::The aim of this study was to compare the outcomes of elective neck dissection (END) with that of a more conservative approach comprising of observation plus therapeutic neck dissection for nodal relapse (OBS), by conducting a meta-analysis of randomized controlled trials (RCTs) that compare these two surgical approach...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Ren ZH,Xu JL,Li B,Fan TF,Ji T,Zhang CP

    更新日期:2015-11-01 00:00:00

  • Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer.

    abstract:OBJECTIVES:To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). METHODS:OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. RESU...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Huang SH,Perez-Ordonez B,Weinreb I,Hope A,Massey C,Waldron JN,Kim J,Bayley AJ,Cummings B,Cho BC,Ringash J,Dawson LA,Siu LL,Chen E,Irish J,Gullane P,Hui A,Liu FF,Shen X,Xu W,O'Sullivan B

    更新日期:2013-01-01 00:00:00

  • Multi-modality 3D mandibular resection planning in head and neck cancer using CT and MRI data fusion: A clinical series.

    abstract:OBJECTIVES:3D virtual surgical planning (VSP) and guided surgery has been proven to be an effective tool for resection and reconstruction of the mandible. Currently, most widely used 3D VSP approaches to mandibular resection do not include detailed tumour information in the VSP. This manuscript presents a strategy wher...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kraeima J,Dorgelo B,Gulbitti HA,Steenbakkers RJHM,Schepman KP,Roodenburg JLN,Spijkervet FKL,Schepers RH,Witjes MJH

    更新日期:2018-06-01 00:00:00

  • Smoking has a negative impact upon health related quality of life after treatment for head and neck cancer.

    abstract::To examine the influence of smoking on observer based morbidity scores and patient assessed health related quality of life after treatment for head and neck cancer. The results of EORTC C30 and H&N35 questionnaires and DAHANCA morbidity scores were studied according to smoking status in 114 recurrence free head and ne...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Jensen K,Jensen AB,Grau C

    更新日期:2007-02-01 00:00:00

  • The role of basement membrane proteins on the expression of neural cell adhesion molecule (N-CAM) in an adenoid cystic carcinoma cell line.

    abstract::We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: França CM,Jaeger MM,Jaeger RG,Araújo NS

    更新日期:2000-03-01 00:00:00

  • Lip cancer experience in Mexico. An 11-year retrospective study.

    abstract::Lip cancer is the most frequent malignant neoplasm of the oral cavity; however, there is no information available on the incidence of this type of cancer in Mexico. This study provides information about the clinico-pathological features of lip cancer patients admitted at a cancer hospital in Mexico City during an 11-y...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Luna-Ortiz K,Güemes-Meza A,Villavicencio-Valencia V,Mosqueda-Taylor A

    更新日期:2004-11-01 00:00:00

  • Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder?

    abstract::Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ficarra G,Prignano F,Romagnoli P

    更新日期:1997-09-01 00:00:00