Podoplanin expression in oral leukoplakia: tumorigenic role.

abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease and although classified by WHO as a premalignant condition, the risk for transformation into squamous cell carcinoma of the head and neck (SCCHN) is a matter of great controversy. The p63 gene encodes six different proteins which are required for development o...

journal_title：Oral oncology

authors： Ebrahimi M,Boldrup L,Wahlin YB,Coates PJ,Nylander K

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:This study aims to compare the prognoses outcomes of mandibular preservation method (MPM) and the mandibulotomy approach (MLA) in oral and oropharyngeal cancer (OOPC) patients. METHOD:We searched PubMed, Web of Science, EMBASE, Chinese BioMedical Literature Database (CBM), Cochrane Library, and clinicaltrial...

journal_title：Oral oncology

authors： Pang P,Li RW,Shi JP,Xu ZF,Duan WY,Liu FY,Huang SH,Tan XX,Sun CF

更新日期：2016-12-01 00:00:00

abstract：:Intraosseous hemangioma is a benign vascular neoplasm and seldom affects the mandible. The diagnosis is challenging owing to its unspecific clinical and radiographic findings. Treatment options in children should be elective based on their age, symptoms, and facial deformity. Herein a rare case of intraosseous hemangi...

journal_title：Oral oncology

authors： Madiraju GS

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Log odds of positive lymph nodes (LODDS) was reported to be significantly associated with prognosis in several malignant tumors. However, few are the studies on the correlation between LODDS and overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:A retrospective...

journal_title：Oral oncology

authors： Jin W,Zhu Z,Wu Y,Ding X,Wu H,Song X,Wu Y

更新日期：2020-09-01 00:00:00

abstract：:In the last decade, human microbiome research is rapidly growing involving several fields of clinical medicine and population health. Although the microbiome seems to be linked to all sorts of diseases, cancer has the biggest potential to be investigated. Following the publication of the National Institute of Health -...

journal_title：Oral oncology

authors： Orlandi E,Iacovelli NA,Tombolini V,Rancati T,Polimeni A,De Cecco L,Valdagni R,De Felice F

更新日期：2019-12-01 00:00:00

abstract：:Patients with HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are significantly different with regard to sociodemographic and behavioral characteristics that clinicians may use to assume tumor HPV status. Machine learning methods were used to evaluate the predictive value of patient charact...

journal_title：Oral oncology

authors： D'Souza G,Zhang HH,D'Souza WD,Meyer RR,Gillison ML

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:We assess the incremental cost-effectiveness ratio (ICER) of the oral cancer (OC) screening program in Taiwan. MATERIALS AND METHODS:We interlinked the Cancer Registry, Mortality Registry, National Vital Statistics, reimbursement database of National Health Insurance, and the National Oral Cancer Screening ...

journal_title：Oral oncology

authors： Huang CC,Lin CN,Chung CH,Hwang JS,Tsai ST,Wang JD

更新日期：2019-02-01 00:00:00

abstract：:Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...

journal_title：Oral oncology

authors： Faust RA,Tawfic S,Davis AT,Ahmed K

更新日期：1999-05-01 00:00:00

abstract：:Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating...

journal_title：Oral oncology

authors： Gensheimer MF,Le QT

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...

journal_title：Oral oncology

authors： Wolf GT,Winter W,Bellile E,Nguyen A,Donnelly CR,McHugh JB,Thomas D,Amlani L,Rozek L,Lei YL,Head and Neck SPORE Program.

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:In carefully selected oral cavity cancers, marginal mandibulectomy is an adequate procedure which achieves good disease control adhering to the principle of "doing as little as possible and as much as necessary". METHODOLOGY:This was a retrospective study done by reviewing the medical records of all patient...

journal_title：Oral oncology

authors： Suresh S,Thomas S,Janardhan D,Patil S,George NA,Varghese BT,Iype EM,Rafi M,George CK

更新日期：2019-08-01 00:00:00

abstract：:Expression profile of 588 known genes relating to tumour biology, was examined between oral squamous cell carcinomas (OSCCs) and matching normal oral mucosal tissues (NOMTs) obtained from Sudanese (n=11) and Norwegian (n=11) patients. cDNA probes were synthesised from total RNA and hybridised with the Atlas human canc...

journal_title：Oral oncology

authors： Ibrahim SO,Aarsaether N,Holsve MK,Kross KW,Heimdal JH,Aarstad JH,Liavaag PG,Elgindi OA,Johannessen AC,Lillehaug JR,Vasstrand EN

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...

journal_title：Oral oncology

authors： Pierce Campbell CM,Giuliano AR,Torres BN,O'Keefe MT,Ingles DJ,Anderson RL,Teras LR,Gapstur SM

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer cell lines that have remained uncharacterized despite being used as model systems for decades. MATERIALS AND METHODS:We performed exome sequencing on 14 oral cavity UM-SCC cell lines and denote the mutational profile of each line. ...

journal_title：Oral oncology

authors： Ludwig ML,Kulkarni A,Birkeland AC,Michmerhuizen NL,Foltin SK,Mann JE,Hoesli RC,Devenport SN,Jewell BM,Shuman AG,Spector ME,Carey TE,Jiang H,Brenner JC

更新日期：2018-12-01 00:00:00

abstract：:Cell lines developed from head and neck squamous cell carcinomas exhibit variable responses to the negative regulatory effects of transforming growth factor beta (TGF beta) on cell growth. To analyse the effects of TGF beta on regulators of cell cycle progression, we characterised cell lines derived from head and neck...

journal_title：Oral oncology

authors： Lesaca EE,Ensley JF,Yeudall WA

更新日期：1998-01-01 00:00:00

abstract：:Thyroid cancer metastasizes to regional lymph nodes early and often. The impact of these metastases on outcome depends on the histological subtype and the size, number and location of those metastases, as well as patient's age. Whilst clinically apparent lateral nodal metastases have a significant impact on both survi...

journal_title：Oral oncology

authors： Nixon IJ,Shaha AR

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To identify predictors of unplanned hospitalization and emergency department (ED) use among head and neck oncology patients. METHODS:Peer reviewed publications were identified through a systematic search of MEDLINE, Embase and Cochrane CENTRAL. Studies describing a cohort of HNC patients that detailed predic...

journal_title：Oral oncology

authors： Noel CW,Forner D,Wu V,Enepekides D,Irish JC,Husain Z,Chan KKW,Hallet J,Coburn N,Eskander A

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The optimal treatment for T3 glottic cancers continues to be debated. Organ preservation has become the standard of care, but not all tumors respond equally. The purpose of this was to investigate the long-term survival outcomes of organ preservation protocols based on tumor volume. METHODS:A retrospective ...

journal_title：Oral oncology

authors： Dziegielewski PT,Reschly WJ,Morris CG,DeJesus RD,Silver N,Boyce BJ,Santiago I 3rd,Amdur RJ,Mendenhall WM

更新日期：2018-04-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

journal_title：Oral oncology

authors： Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

更新日期：2009-03-01 00:00:00

abstract：:Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

journal_title：Oral oncology

authors： Ficarra G,Prignano F,Romagnoli P

更新日期：1997-09-01 00:00:00

abstract：:In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard d...

journal_title：Oral oncology

authors： Ramírez-Amador V,Esquivel-Pedraza L,Lozada-Nur F,De la Rosa-García E,Volkow-Fernández P,Súchil-Bernal L,Mohar A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:...

journal_title：Oral oncology

authors： Xuelei M,Jingwen H,Wei D,Hongyu Z,Jing Z,Changle S,Lei L

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

journal_title：Oral oncology

authors： Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

更新日期：2017-06-01 00:00:00

abstract：:The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...

journal_title：Oral oncology

authors： Huang SF,Chen IH,Liao CT,Wang HM,Liou SH,Hsieh LL

更新日期：2009-01-01 00:00:00

abstract：:Epidemiological studies showed that stopping smoking substantially decreases the risk of lung cancer. With reference to laryngeal cancer, at least four cohort studies and 15 case-control studies reported information on smoking cessation. These studies indicated that the risk of laryngeal cancer is considerably reduced...

journal_title：Oral oncology

authors： Bosetti C,Garavello W,Gallus S,La Vecchia C

更新日期：2006-10-01 00:00:00

abstract：:Sarcomas developing after radiation treatment for primary malignancies of the head and neck are often detected clinically when they are very aggressive. We reviewed the patient demographics and imaging findings in 21 patients with radiation-associated sarcomas (RAS) of the head and neck treated at our institution. Twe...

journal_title：Oral oncology

authors： Debnam JM,Guha-Thakurta N,Mahfouz YM,Garden AS,Benjamin RS,Sturgis EM,Ginsberg LE

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

journal_title：Oral oncology

authors： El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

更新日期：2019-03-01 00:00:00

abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

journal_title：Oral oncology

authors： Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

更新日期：2015-12-01 00:00:00

abstract：:Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...

journal_title：Oral oncology

authors： Elango KJ,Anandkrishnan N,Suresh A,Iyer SK,Ramaiyer SK,Kuriakose MA

更新日期：2011-07-01 00:00:00