Abstract:
PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to January 1, 2009. We assessed standardized mortality ratios (SMR) and absolute excess mortality (AEM), comparing observed cause-specific mortality with expected mortality for our cohort based on general population mortality rates. RESULTS:Median survival was 3.9 years. Overall, the study population experienced a 6-fold higher (95% Confidence Interval (95% CI) 5.9-6.1) mortality risk compared with the general population. After three years, 41% of OP and 29% of OC patients had died due to cancer of the oral cavity and pharynx. Additionally, OC and OP patients experienced high excess mortality from esophageal (SMR 10.6 and 17.9) and lung cancer (SMR 4.6 and 6.3). With regard to non-cancer deaths, the highest AEMs were due to diseases of the circulatory system, with OC patients experiencing an AEM of 11.3 per 10,000 person-years for ischemic heart disease. OP patients experienced excess mortality due to pneumonia (AEM 22.1 per 10,000 person-years). The risk of death due to diseases of the digestive system was for OP and OC patients where about equal (AEM 28.7 and 23.80, respectively). The SMR for death due to pneumonia was more than two times higher (4.4 vs. 1.7) for OP patients than for OC patients (P<0.001). From 15 years after diagnosis, second tumors located outside the head and neck region accounted for most of the excess mortality. CONCLUSIONS:Excess mortality in OC and OP patients appears to be dominated by effects of heavy tobacco and alcohol use with high AEM due to second tumors, respiratory, cardiovascular and gastrointestinal diseases. Patients with OP experienced more than two times higher risk of death due to pneumonia than OC patients. Therefore, awareness of this potential complication should be raised along with development of prevention strategies.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
van Monsjou HS,Schaapveld M,Hamming-Vrieze O,de Boer JP,van den Brekel MW,Balm AJdoi
10.1016/j.oraloncology.2015.10.013subject
Has Abstractpub_date
2016-01-01 00:00:00pages
37-44eissn
1368-8375issn
1879-0593pii
S1368-8375(15)00357-7journal_volume
52pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract:OBJECTIVES:Little is understood about what happens to the vascular pedicle following free tissue transfer in the head and neck region. The viability of a free flap completely depends on the vascular supply by its vascular pedicle until neovascularization occurs from surrounding tissues. The aim of this study is to find...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2016.12.013
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to compare the outcomes of elective neck dissection (END) with that of a more conservative approach comprising of observation plus therapeutic neck dissection for nodal relapse (OBS), by conducting a meta-analysis of randomized controlled trials (RCTs) that compare these two surgical approach...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.oraloncology.2015.08.009
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.105146
更新日期:2021-01-16 00:00:00
abstract::The aim of this study was to evaluate the reliability and utility of a histoculture drug response assay (HDRA) for treatment of squamous cell carcinoma in the oral cavity. Nineteen patients with squamous cell carcinoma of the oral cavity were assessed. Tumor tissue samples were histocultured on Gelfoam sponge gels in ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(03)00082-4
更新日期:2003-10-01 00:00:00
abstract::In loco-regionally advanced head and neck squamous cell cancer (HNSCC), concurrent 3-weekly cisplatin improves overall survival (OS) compared to radiotherapy alone, but is often associated with renal toxicity. The use of radiotherapy with accelerated fractionation schedules has been reported to improve survival but it...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.10.005
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2017.02.014
更新日期:2017-04-01 00:00:00
abstract::We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(01)00004-5
更新日期:2001-09-01 00:00:00
abstract::Integrins are a family of heterodimeric, cation-dependent cell membrane adhesion molecules which mediate cell-cell and cell-matrix interactions. They play a fundamental role in the maintenance of tissue integrity and in the regulation of cell proliferation, growth, differentiation and migration. It is not surprising, ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s0964-1955(97)00021-3
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2012.08.003
更新日期:2013-02-01 00:00:00
abstract::The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dyspl...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.12.014
更新日期:2006-11-01 00:00:00
abstract::Retinoids are the natural and synthetic derivatives of vitamin A. Epidemiological studies indicate that a low intake of vitamin A is associated with an increased risk of squamous cancer. In vitro studies on cancer cells show that exposure to retinoids results in the inhibition of growth, by blocking the cell cycle or ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s1368-8375(01)00118-x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.09.023
更新日期:2019-11-01 00:00:00
abstract::Our aim of the study was to investigate the precise relationship of repair cross-complementation group 1 (ERCC1) expression and the survival as well as objective response rate to cisplatin-based concurrent chemoradiotherapy (CCRT) and a meta-analysis was conducted to analysis ERCC1's prognostic roles in head and neck ...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.oraloncology.2015.03.009
更新日期:2015-06-01 00:00:00
abstract::Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2018.08.010
更新日期:2018-11-01 00:00:00
abstract::We assessed the risk factors associated with surgical site infection (SSI) in 697 patients who underwent major oncological surgery for head-and-neck cancer (HNC). SSIs within 30days were classified as incision, space, or leakage/fistula. Preoperative and operative risk factors for SSIs were assessed by univariate and ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.04.002
更新日期:2011-06-01 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2009.12.005
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the new American Joint Committee on Cancer (AJCC) cancer staging manual (8th edition) in an independent cohort of patients surgically treated for oral squamous cell carcinoma in order to determine whether the upstaging of pT and pN classification was indicative of a worse prognosis. METHODS:A co...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.05.020
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Elective neck dissection (END) for salvage laryngectomy remains controversial due to variability in reported occult nodal metastasis rates and postoperative complications. We performed a meta-analysis to examine the role of END for treatment of the clinically N0 (cN0) neck in the salvage setting. METHODS:A P...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析
doi:10.1016/j.oraloncology.2019.07.008
更新日期:2019-09-01 00:00:00
abstract::Salivary gland carcinomas are a rare and clinically diverse group of neoplasms among which mucoepidermoid carcinomas (MEC) are reported to be the most frequently encountered. During the years 1994-2004 18 patients with MEC were treated in our Department. All patients underwent surgery with a curative intent, and in 11...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2006.03.001
更新日期:2007-02-01 00:00:00
abstract::Thyroid cancer metastasizes to regional lymph nodes early and often. The impact of these metastases on outcome depends on the histological subtype and the size, number and location of those metastases, as well as patient's age. Whilst clinically apparent lateral nodal metastases have a significant impact on both survi...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2013.03.441
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.10.010
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2012.03.024
更新日期:2012-09-01 00:00:00
abstract::The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carci...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile sit...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2007.08.019
更新日期:2008-08-01 00:00:00
abstract::To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.05.006
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:The aim of the present study was to evaluate whether texture features extracted from 18F-FDG PET/CT images may provide additional prognostic information in patients with metastatic nasopharyngeal carcinoma (NPC). MATERIALS AND METHOD:We retrospectively examined 52 patients with metastatic NPC who underwent ass...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104628
更新日期:2020-05-01 00:00:00
abstract::The distributions of 2093 patients with nasopharyngeal carcinoma (NPC), by stage, over a 12-year-period did not show any evidence of a shift towards early stages despite growing awareness of this prevalent malignancy. The IgA VCA titre was determined for 1880 of these patients. The median titre increased from 40 in st...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00063-3
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2021.105182
更新日期:2021-01-24 00:00:00
abstract::We hope to establish a new readmission prediction score for patients with head and neck cancer (HNC) after major cancer surgery. A retrospective cohort study was conducted from the clinical and cancer registry data at Kaohsiung Veterans General Hospital. We included the data of patients with newly diagnosed HNC who un...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104772
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2014.12.004
更新日期:2015-03-01 00:00:00