The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy.

abstract：OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...

journal_title：Oral oncology

authors： Philips R,Topf MC,Graf A,Krein H,Heffelfinger R,Luginbuhl A,Curry J

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:To describe patterns of failure (POF) after reirradiation (reRT) with intensity modulated radiation therapy (IMRT) for recurrent/second primary squamous cell carcinoma of the head and neck. METHODS:From 08/2004-02/2013, 75 consecutive patients received reRT with IMRT. Gross tumor was generally treated with a 5...

journal_title：Oral oncology

authors： Margalit DN,Rawal B,Catalano PJ,Haddad RI,Goguen LA,Annino DJ,Limaye SA,Lorch JH,Lavigne AW,Schoenfeld JD,Sher DJ,Tishler RB

更新日期：2016-10-01 00:00:00

abstract：:Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are res...

journal_title：Oral oncology

authors： Adams A,Warner K,Nör JE

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:Little is understood about what happens to the vascular pedicle following free tissue transfer in the head and neck region. The viability of a free flap completely depends on the vascular supply by its vascular pedicle until neovascularization occurs from surrounding tissues. The aim of this study is to find...

journal_title：Oral oncology

authors： Van Genechten ML,Batstone MD

更新日期：2017-02-01 00:00:00

abstract：:Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...

journal_title：Oral oncology

authors： Chen P,Lingen M,Sonis ST,Walsh-Reitz MM,Toback FG

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...

journal_title：Oral oncology

authors： Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TK

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...

journal_title：Oral oncology

authors： Fujiwara RJT,Burtness B,Husain ZA,Judson BL,Bhatia A,Sasaki CT,Yarbrough WG,Mehra S

更新日期：2017-08-01 00:00:00

abstract：:Hyalinizing clear cell carcinoma (HCCC) is a recently described low-grade carcinoma of the salivary glands presenting two main histological features: clear neoplastic cells and prominent hyalinized stroma. Our aim was to characterize the composition of the hyalinized stroma in three cases of HCCC. An immuno-histochemi...

journal_title：Oral oncology

authors： Félix A,Rosa JC,Nunes JF,Fonseca I,Cidadão A,Soares J

更新日期：2002-06-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that are involved in the remodeling of chromatin and play a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypoacetylation. In recent years, inhibition of HDACs has emerged as a ...

journal_title：Oral oncology

authors： Iglesias-Linares A,Yañez-Vico RM,González-Moles MA

更新日期：2010-05-01 00:00:00

abstract：:Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...

journal_title：Oral oncology

authors： Wong DT,Bowen SM,Elovic A,Gallagher GT,Weller PF

更新日期：1999-09-01 00:00:00

abstract：:The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. FHIT is frequently abnormal in solid tumours including those of the upper aerodigestive tract (UAT) and has therefore been proposed as a tumour-suppressor gene. T...

journal_title：Oral oncology

authors： Pateromichelakis S,Lee G,Langdon JD,Partridge M

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To evaluate a single-institutional experience with the use of re-irradiation for recurrent and new primary cancers of the head and neck. METHODS:The medical charts of 80 consecutive patients who underwent re-irradiation for local-regionally recurrent or second primary head and neck cancer between November 1998...

journal_title：Oral oncology

authors： Velez MA,Veruttipong D,Wang PC,Chin R,Beron P,Abemayor E,St John M,Chen AM

更新日期：2017-04-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：:The etiology of oral squamous cell carcinoma has been linked to environmental carcinogens, such as activated aromatic heterocyclic radicals and epoxides. Our previous work on implantable and 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer showed that oral glutamine (GLN) inhibited tumor growth possibly thr...

journal_title：Oral oncology

authors： Lim V,Korourian S,Todorova VK,Kaufmann Y,Klimberg VS

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...

journal_title：Oral oncology

authors： Scher ED,Romesser PB,Chen C,Ho F,Wuu Y,Sherman EJ,Fury MG,Wong RJ,McBride S,Lee NY,Riaz N

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Based on their distinctive histologic and genetic features, the latest WHO classification of soft tissue tumors includes four pathologic variants of rhabdomyosarcoma (RMS): embryonal (ERMS), alveolar (ARMS), spindle cell-sclerosing (SRMS-ScRMS) and pleomorphic RMS. The aim of this study focused on a detailed...

journal_title：Oral oncology

authors： Owosho AA B Ch D,Huang SC Md,Chen S Mbbs,Kashikar S Dds,Estilo CL Dmd,Wolden SL Md,Wexler LH Md,Huryn JM Dds,Antonescu CR Md

更新日期：2016-10-01 00:00:00

abstract：:Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection ...

journal_title：Oral oncology

authors： Borsetto D,Fussey J,Fabris L,Bandolin L,Gaudioso P,Phillips V,Polesel J,Boscolo-Rizzo P

更新日期：2020-06-26 00:00:00

abstract：:The present study sought to determine the potential role of stress activated MAPK and phosphatidylinositol 3-kinase (PI3K) signaling pathways in mediating phenotypic switching between angiogenic and angiostatic elements among squamous cell carcinoma (SCC) cell lines. In particular, we investigated the effects of hypox...

journal_title：Oral oncology

authors： Stewart J,Siavash H,Hebert C,Norris K,Nikitakis NG,Sauk JJ

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:The treatment strategy of early stage oral squamous cell carcinoma's (OSCC) resected with close or involved margins is a returning point of discussion. In this study we reviewed the consequences of re-resection (RR), postoperative radiotherapy (PORT) or watchful waiting (WW). PATIENTS AND METHODS:Two-hundre...

journal_title：Oral oncology

authors： Dik EA,Willems SM,Ipenburg NA,Adriaansens SO,Rosenberg AJ,van Es RJ

更新日期：2014-06-01 00:00:00

abstract：:This systematic review gives an extensive overview of the current state of functional imaging during (chemo)radiotherapy to predict locoregional control (LRC) and overall survival (OS) for head and neck squamous cell carcinoma. MEDLINE and EMBASE were searched for literature until April 2018 assessing the predictive p...

journal_title：Oral oncology

authors： Martens RM,Noij DP,Ali M,Koopman T,Marcus JT,Vergeer MR,de Vet H,de Jong MC,Leemans CR,Hoekstra OS,de Bree R,de Graaf P,Boellaard R,Castelijns JA

更新日期：2019-01-01 00:00:00

abstract：:Intraosseous hemangioma is a benign vascular neoplasm and seldom affects the mandible. The diagnosis is challenging owing to its unspecific clinical and radiographic findings. Treatment options in children should be elective based on their age, symptoms, and facial deformity. Herein a rare case of intraosseous hemangi...

journal_title：Oral oncology

authors： Madiraju GS

更新日期：2020-09-01 00:00:00

abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

journal_title：Oral oncology

authors： Sonis ST

更新日期：2009-12-01 00:00:00

abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

journal_title：Oral oncology

authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

更新日期：2000-09-01 00:00:00

abstract：:Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagno...

journal_title：Oral oncology

authors： Riffat F,Dwivedi RC,Palme C,Fish B,Jani P

更新日期：2014-05-01 00:00:00

abstract：:Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...

journal_title：Oral oncology

authors： Faust RA,Tawfic S,Davis AT,Ahmed K

更新日期：1999-05-01 00:00:00

abstract：:Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...

journal_title：Oral oncology

authors： Atabo A,Bradley PJ

更新日期：2008-03-01 00:00:00

abstract：:Facial Paralysis (FP) profoundly impairs the life of individuals, both functionally and psychosocially. Surgical approaches to treat this condition are myriad, but the ultimate goal is to restore symmetry and movement. Ablative surgery for tumors of the head and neck region are amongst the most common etiologies causi...

journal_title：Oral oncology

authors： Sahovaler A,Yeh D,Yoo J

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:We aimed to develop a dual-task model to detect and segment nasopharyngeal carcinoma (NPC) automatically in magnetic resource images (MRI) based on deep learning method, since the differential diagnosis of NPC and atypical benign hyperplasia was difficult and the radiotherapy target contouring of NPC was lab...

journal_title：Oral oncology

authors： Ke L,Deng Y,Xia W,Qiang M,Chen X,Liu K,Jing B,He C,Xie C,Guo X,Lv X,Li C

更新日期：2020-11-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently...

journal_title：Oral oncology

authors： Martinez-Useros J,Garcia-Foncillas J

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into...

journal_title：Oral oncology

authors： Aghbari SMH,Abushouk AI,Attia A,Elmaraezy A,Menshawy A,Ahmed MS,Elsaadany BA,Ahmed EM

更新日期：2017-05-01 00:00:00