The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer.

abstract：BACKGROUND:Head and neck mucosal melanoma (HNMM) is a rare and aggressive disease with a high metastatic potential. Two staging systems are currently available: one specific to HNMM (mmTNM) and one specific to primary tumour sites (sccTNM). Our main objective was to assess the prognostic value of both of these classifi...

journal_title：Oral oncology

authors： Moya-Plana A,Mangin D,Dercle L,Taouachi R,Casiraghi O,Ammari S,Nguyen F,Temam S,Robert C,Gorphe P

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral...

journal_title：Oral oncology

authors： Chen PY,Chen HH,Hsiao JR,Yang MW,Hsueh WT,Tasi ST,Lin FC,Wu YH

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...

journal_title：Oral oncology

authors： Mercadante V,Al Hamad A,Lodi G,Porter S,Fedele S

更新日期：2017-03-01 00:00:00

abstract：:The concept of dysplasia/neoplasia surveillance has been applied to long-standing conditions associated with an increased risk of cancer. Although still controversial, periodic direct clinical examination as well as endoscopic techniques are currently performed in patients with inflammatory bowel diseases, Barrett's e...

journal_title：Oral oncology

authors： Mignogna MD,Fedele S,Lo Russo L

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...

journal_title：Oral oncology

authors： Grønhøj C,Kronberg Jakobsen K,Kjær E,Friborg J,von Buchwald C

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass Spectrometry holds promise as a non-invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may significantly improve the early diagnosis of oral cancer. The present study was designed to discriminate between tumour...

journal_title：Oral oncology

authors： Maurer K,Eschrich K,Schellenberger W,Bertolini J,Rupf S,Remmerbach TW

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic...

journal_title：Oral oncology

authors： Liu C,Liao L,Wu G,Yan H,Chen X,Wang C,Zheng X,Zeng Z,Zhao Z,Wu D,Liu X

更新日期：2020-06-27 00:00:00

abstract：:Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here, we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ extract (BQE) increased the secretion of an 85kDa caseinolytic proteinase, specifically precipitated by an anti-MMP-8 antibody, in the c...

journal_title：Oral oncology

authors： Liu SY,Liu YC,Huang WT,Huang GC,Chen TC,Lin MH

更新日期：2007-11-01 00:00:00

abstract：:Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile sit...

journal_title：Oral oncology

authors： Pimenta FJ,Cordeiro GT,Pimenta LG,Viana MB,Lopes J,Gomez MV,Aldaz CM,De Marco L,Gomez RS

更新日期：2008-08-01 00:00:00

abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

journal_title：Oral oncology

authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

更新日期：2006-01-01 00:00:00

abstract：:To assess the prognostic value of apoptosis, proliferation and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Between 1985 and 1995, a total of 82 patients with 84 tumors were entered onto the study. Forty-two primary tumors (50%) involved the t...

journal_title：Oral oncology

authors： Grabenbauer GG,Suckorada O,Niedobitek G,Rödel F,Iro H,Sauer R,Rödel C,Schultze-Mosgau S,Distel L

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVES:This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS:Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral pre...

journal_title：Oral oncology

authors： Cheng SJ,Chang CF,Lee JJ,Chen HM,Wang HJ,Liou YL,Yen C,Chiang CP

更新日期：2016-11-01 00:00:00

abstract：:Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...

journal_title：Oral oncology

authors： Shiah SG,Chang LC,Tai KY,Lee GH,Wu CW,Shieh YS

更新日期：2009-01-01 00:00:00

abstract：:Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...

journal_title：Oral oncology

authors： Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJ

更新日期：2011-10-01 00:00:00

abstract：:We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...

journal_title：Oral oncology

authors： Oliveira PT,Jaeger RG,Cabral LA,Carvalho YR,Costa AL,Jaeger MM

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To evaluate a single-institutional experience with the use of re-irradiation for recurrent and new primary cancers of the head and neck. METHODS:The medical charts of 80 consecutive patients who underwent re-irradiation for local-regionally recurrent or second primary head and neck cancer between November 1998...

journal_title：Oral oncology

authors： Velez MA,Veruttipong D,Wang PC,Chin R,Beron P,Abemayor E,St John M,Chen AM

更新日期：2017-04-01 00:00:00

abstract：:Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...

journal_title：Oral oncology

authors： Faust RA,Tawfic S,Davis AT,Ahmed K

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:Esophageal second primary tumors (SPTs) in head and neck cancer (HNC) patients is not uncommon. The impact of image-enhanced endoscopy (IEE) screening for esophageal SPT on the outcome of HNC patients has not been well clarified. METHODS AND METHODS:Patients with malignancies of the head and neck region and...

journal_title：Oral oncology

authors： Chung CS,Lo WC,Chen KC,Lin CL,Wen MH,Hsieh CH,Lin SC,Liao LJ

更新日期：2019-09-01 00:00:00

abstract：:Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

journal_title：Oral oncology

authors： Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

更新日期：2014-08-01 00:00:00

abstract：:Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies t...

journal_title：Oral oncology

authors： Crivelini MM,de Sousa SO,de Araújo VC

更新日期：1997-05-01 00:00:00

abstract：:Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genet...

journal_title：Oral oncology

authors： Freier K,Schwaenen C,Sticht C,Flechtenmacher C,Mühling J,Hofele C,Radlwimmer B,Lichter P,Joos S

更新日期：2007-01-01 00:00:00

abstract：:The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process an...

journal_title：Oral oncology

authors： Zolkind P,Dunn GP,Lin T,Griffith M,Griffith OL,Uppaluri R

更新日期：2017-08-01 00:00:00

abstract：:The role of chemotherapy (CHX) in squamous cell carcinoma of the head and neck (SCCHN) has been expanding. Although combination chemotherapy regimens regularly produce significantly high response rates, meta-analyses show little benefit regarding final outcome. One way to improve induction CHX is to improve drug combi...

journal_title：Oral oncology

authors： Sasaki Y,Kjellén E,Ekblad L,Wahlberg P,Mineta H,Wennerberg J

更新日期：2012-01-01 00:00:00

abstract：:A series of patients with oral squamous cell carcinoma (SCC) observed at the "Regina Elena" Cancer Institute was retrospectively reviewed in order to analyse the risk factors for multiple and second primary tumours (SPTs), their impact on survival and effective measures to control this phenomenon. In a survey of 200 i...

journal_title：Oral oncology

authors： Cianfriglia F,Di Gregorio DA,Manieri A

更新日期：1999-03-01 00:00:00

abstract：:The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...

journal_title：Oral oncology

authors： Kurihara K,Tajima Y,Kawasaki M,Ueha T

更新日期：1999-07-01 00:00:00

abstract：:The present study was conducted to evaluate the therapeutic results of alternating chemoradiotherapy for locally advanced nasopharyngeal cancer. The subjects were 87 patients with stage II-IVB nasopharyngeal cancer. Alternating chemoradiotherapy was performed; initially, chemotherapy was administered, and then radioth...

journal_title：Oral oncology

authors： Fuwa N,Shikama N,Hayashi N,Matsuzuka T,Toita T,Yuta A,Oonishi H,Kodaira T,Tachibana H,Nakamura T,Daimon T

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...

journal_title：Oral oncology

authors： Al-Mamgani A,Monserez D,Rooij Pv,Verduijn GM,Hardillo JA,Levendag PC

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To perform a systematic review of 1762 patients to comprehensively assess the benefit of altered-fractionation radiotherapy (ART) in early stage glottic carcinoma (ESGC). MATERIALS AND METHODS:Studies were identified in PubMed and EMBASE. Inclusion criteria were: (1) diagnosis of squamous cell ESGC (Tis, T1...

journal_title：Oral oncology

authors： Sapienza LG,Ning MS,Taguchi S,Calsavara VF,Pellizzon ACA,Gomes MJL,Kowalski LP,Baiocchi G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Results of the Dutch multi-institutional trial on sentinel lymph node (SLN) biopsy in oral cancer. PATIENTS AND METHODS:Patients were consecutively enrolled from 4 institutions, with T1/T2 oral cancer and cN0 neck based on palpation and ultrasound guided fine needle aspiration cytology. Lymphatic mapping co...

journal_title：Oral oncology

authors： Flach GB,Bloemena E,Klop WM,van Es RJ,Schepman KP,Hoekstra OS,Castelijns JA,Leemans CR,de Bree R

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To identify predictors of unplanned hospitalization and emergency department (ED) use among head and neck oncology patients. METHODS:Peer reviewed publications were identified through a systematic search of MEDLINE, Embase and Cochrane CENTRAL. Studies describing a cohort of HNC patients that detailed predic...

journal_title：Oral oncology

authors： Noel CW,Forner D,Wu V,Enepekides D,Irish JC,Husain Z,Chan KKW,Hallet J,Coburn N,Eskander A

更新日期：2020-12-01 00:00:00