Abstract：
:Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous studies have demonstrated that molecular changes of the WWOX gene (WW-domain containing oxidoreductase), a candidate tumor suppressor gene located at 16q23.3-24.1 that spans FRA16D, the second most common fragile site, are present in several malignant neoplasias, including oral squamous cell carcinoma. In this report, the role of the WWOX gene was investigated in 23 cases of oral leukoplakias. Using nested RT-PCR and immunohistochemistry, altered mRNA transcription and/or reduced Wwox protein expression was observed in 35% of the lesions when compared with normal mucosa. The majority of lesions (4/6) with altered transcripts had a reduction in the expression of Wwox protein. Although normal WWOX expression was found in some lesions with dysplasia, all lesions with WWOX mRNA and/or protein expression showed histological evidence of dysplasia and none of the cases without dysplasia presented this alteration. These results show that the WWOX gene alteration is an early genetic alteration and may contribute to oral carcinogenesis.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Pimenta FJ,Cordeiro GT,Pimenta LG,Viana MB,Lopes J,Gomez MV,Aldaz CM,De Marco L,Gomez RSdoi
10.1016/j.oraloncology.2007.08.019subject
Has Abstractpub_date
2008-08-01 00:00:00pages
753-8issue
8eissn
1368-8375issn
1879-0593pii
S1368-8375(07)00254-0journal_volume
44pub_type
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