Abstract：
:Systemic chemotherapy is increasingly being used with radiotherapy for the radical treatment of advanced head and neck cancers. Chemotherapy offers modest benefits in the metastatic setting. Platinum containing agents are the most active drugs and form the mainstay of most chemotherapy schedules. In recent years taxanes have been shown activity in head and neck cancers and are being incorporated into neo-adjuvant and concomitant chemotherapy regimens. Targeted agents EGFR inhibitors like cetuximab, in particular have shown benefit in the metastatic and the concomitant setting. EGFR inhibitors and other targeted agents form the thrust of pre-clinical and clinical research into systemic treatment of head and neck cancer.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Bhide SA,Nutting CMdoi
10.1016/j.oraloncology.2010.03.004subject
Has Abstractpub_date
2010-06-01 00:00:00pages
436-8issue
6eissn
1368-8375issn
1879-0593pii
S1368-8375(10)00093-Xjournal_volume
46pub_type
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