The role of basement membrane proteins on the expression of neural cell adhesion molecule (N-CAM) in an adenoid cystic carcinoma cell line.

Abstract:

:We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. Control cells presented a scattered N-CAM expression on cell membrane, and type IV collagen had no effect in N-CAM distribution. CAC2 cells grown on laminin-coated coverslips expressed N-CAM concentrated on cell lamellipodia suggesting relationship with migratory activity. Our results showed that cultured adenoid cystic carcinoma cells express N-CAM and this expression is modulated by extracellular matrix.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

França CM,Jaeger MM,Jaeger RG,Araújo NS

doi

10.1016/s1368-8375(99)00087-1

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

248-52

issue

2

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(99)00087-1

journal_volume

36

pub_type

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