Abstract:
:We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. Control cells presented a scattered N-CAM expression on cell membrane, and type IV collagen had no effect in N-CAM distribution. CAC2 cells grown on laminin-coated coverslips expressed N-CAM concentrated on cell lamellipodia suggesting relationship with migratory activity. Our results showed that cultured adenoid cystic carcinoma cells express N-CAM and this expression is modulated by extracellular matrix.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
França CM,Jaeger MM,Jaeger RG,Araújo NSdoi
10.1016/s1368-8375(99)00087-1subject
Has Abstractpub_date
2000-03-01 00:00:00pages
248-52issue
2eissn
1368-8375issn
1879-0593pii
S1368-8375(99)00087-1journal_volume
36pub_type
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