The prognostic significance of age in oropharyngeal squamous cell carcinoma.

abstract：:The aims of this study were to assess a cohort of patients with head and neck squamous cell carcinoma (HNSCC) for: (1) the prevalence of synchronous distant metastases (DM) as detected by the initial staging by using (18)F-FDG PET/CT, (2) the prevalence of metachronous DM, and (3) the validity of published risk factor...

journal_title：Oral oncology

authors： Haerle SK,Schmid DT,Ahmad N,Hany TF,Stoeckli SJ

更新日期：2011-07-01 00:00:00

abstract：:The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemist...

journal_title：Oral oncology

authors： Kishimoto K,Sasaki A,Yoshihama Y,Mese H,Tsukamoto G,Matsumura T

更新日期：2003-06-01 00:00:00

abstract：:The selection of housekeeping genes is critical for gene expression studies. To address this issue, four candidate housekeeping genes, including several commonly used ones, were investigated in oral squamous cell carcinoma cell lines. A simple quantitative RT-PCR approach was employed by comparing relative expression ...

journal_title：Oral oncology

authors： Campos MS,Rodini CO,Pinto-Júnior DS,Nunes FD

更新日期：2009-02-01 00:00:00

abstract：:The submental artery island flap (SIF) is gaining acceptance as a simple and reliable option in selected oral oncologic reconstructions. The present study aims to assess the usefulness of submental artery flap in oral reconstruction with respect to flap reliability, cosmesis, function, donor site morbidity and oncolog...

journal_title：Oral oncology

authors： Sebastian P,Thomas S,Varghese BT,Iype EM,Balagopal PG,Mathew PC

更新日期：2008-11-01 00:00:00

abstract：:To identify subgroups of oral cavity and pharynx (OCP) cancers that may be etiologically distinct, we evaluated age-adjusted incidence rates by histologic type, anatomical site, race, and sex using cases diagnosed during 1975-1998 in nine US Surveillance, Epidemiology, and End Results (SEER) program registries. Male/f...

journal_title：Oral oncology

authors： Canto MT,Devesa SS

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

journal_title：Oral oncology

authors： Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

更新日期：2018-05-01 00:00:00

abstract：:The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dyspl...

journal_title：Oral oncology

authors： Kujan O,Oliver RJ,Khattab A,Roberts SA,Thakker N,Sloan P

更新日期：2006-11-01 00:00:00

abstract：:This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a...

journal_title：Oral oncology

authors： Mahajan A,Ahuja A,Sable N,Stambuk HE

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Reconstruction of the tongue and floor of mouth after total/subtotal glossectomy poses a major challenge for reconstructive surgeons. Speech and deglutition after total glossectomy are usually significantly impaired, affecting the quality of life of these patients. Maintaining an adequate volume of the recon...

journal_title：Oral oncology

authors： Ferrari M,Sahovaler A,Chan HHL,Nicolai P,Irish JC,Gilbert RW

更新日期：2020-06-01 00:00:00

abstract：:This systematic review analyses and describes the application and diagnostic accuracy of Artificial Intelligence (AI) methods used for detection and grading of potentially malignant (pre-cancerous) and cancerous head and neck lesions using whole slide images (WSI) of human tissue slides. Electronic databases MEDLINE v...

journal_title：Oral oncology

authors： Mahmood H,Shaban M,Indave BI,Santos-Silva AR,Rajpoot N,Khurram SA

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...

journal_title：Oral oncology

authors： Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

更新日期：2015-11-01 00:00:00

abstract：:The present study sought to determine the potential role of stress activated MAPK and phosphatidylinositol 3-kinase (PI3K) signaling pathways in mediating phenotypic switching between angiogenic and angiostatic elements among squamous cell carcinoma (SCC) cell lines. In particular, we investigated the effects of hypox...

journal_title：Oral oncology

authors： Stewart J,Siavash H,Hebert C,Norris K,Nikitakis NG,Sauk JJ

更新日期：2003-12-01 00:00:00

abstract：:Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research fo...

journal_title：Oral oncology

authors： Güneri P,Epstein JB

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:There is a dearth of prospective evidence regarding cancer of the major salivary glands. Outcomes and management of major salivary gland are based largely on retrospective series spanning many decades and changes in surgical, radiation, imaging and systemic therapy strategies and technique. We sought to repo...

journal_title：Oral oncology

authors： Jegadeesh N,Liu Y,Prabhu RS,Magliocca KR,Marcus DM,Higgins KA,Vainshtein JM,Trad Wadsworth J,Beitler JJ

更新日期：2015-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

journal_title：Oral oncology

authors： Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

更新日期：2009-03-01 00:00:00

abstract：:Laryngeal cancer is a rare type of neoplasia, constituting approximately 2% of all human cancers. Mutations of the ras gene family is one of the main activating mechanisms in human cancer. Their involvement in head and neck cancer has been mainly demonstrated at the level of the overexpression whereas ras mutations in...

journal_title：Oral oncology

authors： Rizos E,Sourvinos G,Arvanitis DA,Velegrakis G,Spandidos DA

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....

journal_title：Oral oncology

authors： Chau L,Jabara JT,Lai W,Svider PF,Warner BM,Lin HS,Raza SN,Fribley AM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS:Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral pre...

journal_title：Oral oncology

authors： Cheng SJ,Chang CF,Lee JJ,Chen HM,Wang HJ,Liou YL,Yen C,Chiang CP

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

journal_title：Oral oncology

authors： Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

更新日期：2013-02-01 00:00:00

abstract：:Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

journal_title：Oral oncology

authors： Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

更新日期：2006-05-01 00:00:00

abstract：:Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion >1 cm into l...

journal_title：Oral oncology

authors： Dhar H,Vaish R,D'Cruz AK

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

journal_title：Oral oncology

authors： Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

更新日期：2020-12-01 00:00:00

abstract：:This systematic review gives an extensive overview of the current state of functional imaging during (chemo)radiotherapy to predict locoregional control (LRC) and overall survival (OS) for head and neck squamous cell carcinoma. MEDLINE and EMBASE were searched for literature until April 2018 assessing the predictive p...

journal_title：Oral oncology

authors： Martens RM,Noij DP,Ali M,Koopman T,Marcus JT,Vergeer MR,de Vet H,de Jong MC,Leemans CR,Hoekstra OS,de Bree R,de Graaf P,Boellaard R,Castelijns JA

更新日期：2019-01-01 00:00:00

abstract：:Cell lines developed from head and neck squamous cell carcinomas exhibit variable responses to the negative regulatory effects of transforming growth factor beta (TGF beta) on cell growth. To analyse the effects of TGF beta on regulators of cell cycle progression, we characterised cell lines derived from head and neck...

journal_title：Oral oncology

authors： Lesaca EE,Ensley JF,Yeudall WA

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...

journal_title：Oral oncology

authors： Lin NC,Su IH,Hsu JT,Chang YJ,Tsai KY

更新日期：2021-01-16 00:00:00

abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

journal_title：Oral oncology

authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

更新日期：2000-09-01 00:00:00

abstract：:Carboplatin (CBDCA) alone or in combination with irradiation and other chemotherapeutic agents has been used for the treatment of oral squamous carcinoma. However, there are some limitations for such therapy because of inherent or acquired resistance to CBDCA. To gain some insights into the association of CBDCA resist...

journal_title：Oral oncology

authors： Noutomi T,Chiba H,Itoh M,Toyota H,Mizuguchi J

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:Recent preclinical research has renewed interest in the interplay between glucose dysregulation and cancer. Metformin holds promise as an adjunctive antineoplastic agent in head and neck cancer (HNC). We aimed to explore the impact of metformin in HNC patients from a population-based dataset. PATIENTS & MET...

journal_title：Oral oncology

authors： Stokes WA,Eguchi M,Amini A,Hararah MK,Ding D,McDermott JD,Bradley CJ,Karam SD

更新日期：2018-09-01 00:00:00

abstract：:p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of...

journal_title：Oral oncology

authors： Partridge M,Kiguwa S,Emilion G,Pateromichelakis S,A'Hern R,Langdon JD

更新日期：1999-01-01 00:00:00

abstract：:Lymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few cases which occur in adulthood, and approximately 75% of the lesions are located in the head and neck region. The lesions can g...

journal_title：Oral oncology

authors： Zhou Q,Zheng JW,Mai HM,Luo QF,Fan XD,Su LX,Wang YA,Qin ZP

更新日期：2011-12-01 00:00:00