Abstract：
:Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cancer characterized by an increased density of tryptase-positive mast cells. To investigate the possible contribution of tryptase to COX-2 overexpression during early lip carcinogenesis, normal lip (n=24) and AC (n=45) biopsies were processed for COX-2, PAR-2 and tryptase detection, using RT-PCR and immunohistochemistry. Expression scores were obtained for each marker and tested for statistical significance using Mann-Whitney and Spearmann's correlation tests as well as multivariate logistic regression analysis. Increased epithelial co-expression of COX-2 and PAR-2, as well as, elevated subepithelial density of tryptase-positive mast cells were found in AC as compared to normal lip (P<0.001). COX-2 overexpression was found to be a significant predictor of AC (P<0.034, forward stepwise, Wald), and to be correlated with both tryptase-positive mast cells and PAR-2 expression (P<0.01). The results suggest that epithelial COX-2 overexpression is a key event in AC, which is associated with increased tryptase-positive mast cells and PAR-2. Therefore, tryptase may contribute to COX-2 up-regulation by epithelial PAR-2 activation during early lip carcinogenesis.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJdoi
10.1016/j.oraloncology.2008.05.019subject
Has Abstractpub_date
2009-03-01 00:00:00pages
284-90issue
3eissn
1368-8375issn
1879-0593pii
S1368-8375(08)00178-4journal_volume
45pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract：:Several reports have indicated that nuclear factor-kappa B (NF-κB) is constitutively activated in a variety of cancer cells including human oral squamous carcinoma cells, and play a key role in their growth and survival. Recent studies report that NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibits proli...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.03.001
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.06.013
更新日期：2017-08-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.05.014
更新日期：2011-08-01 00:00:00
abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.05.006
更新日期：2010-08-01 00:00:00
abstract：:The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.07.015
更新日期：2009-12-01 00:00:00
abstract：:Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.02.006
更新日期：2010-04-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rou...
journal_title：Oral oncology
pub_type： 信件
doi：10.1016/j.oraloncology.2020.104630
更新日期：2020-07-01 00:00:00
abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2020.104950
更新日期：2020-08-19 00:00:00
abstract：:The zebrafish has become a useful model organism for research on development and diseases. However, there has been no zebrafish model system for studying oral carcinogenesis. In the present study, we first characterized the histology of the upper gastrointestinal tract of zebrafish. We found that zebrafish tongue was ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.09.008
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:The treatment strategy of early stage oral squamous cell carcinoma's (OSCC) resected with close or involved margins is a returning point of discussion. In this study we reviewed the consequences of re-resection (RR), postoperative radiotherapy (PORT) or watchful waiting (WW). PATIENTS AND METHODS:Two-hundre...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.02.014
更新日期：2014-06-01 00:00:00
abstract：:Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblottin...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.01.014
更新日期：2012-07-01 00:00:00
abstract：:To describe outcome and prognostic factors in a national Danish series of patients treated for salivary gland carcinoma. From three Danish nation-wide registries and supplementary patient records, 871 patients diagnosed with primary major or minor salivary gland carcinoma in the period from 1990 to 2005 were identifie...
journal_title：Oral oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.oraloncology.2011.09.005
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.09.006
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Pioglitazone has shown an inhibitory effect on the growth of cell lines derived from human salivary gland and human oral squamous cell carcinoma. However, whether this effect can be applied to patients with type 2 diabetes mellitus who use pioglitazone for glycemic control remains unanswered. METHODS:The re...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2013.10.015
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.02.004
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.02.014
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104712
更新日期：2020-07-01 00:00:00
abstract：:Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of H...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2011.02.009
更新日期：2011-04-01 00:00:00
abstract：:Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Incidence rates increase with sun exposure and after immunosuppression and organ transplantation. A significant proportion of MCC have been reported to...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2003.11.005
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.05.013
更新日期：2016-08-01 00:00:00
abstract：:The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00051-8
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104900
更新日期：2020-11-01 00:00:00
abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.11.010
更新日期：2010-03-01 00:00:00
abstract：:A patient is described who initially presented with pemphigus vulgaris, limited to the oral cavity, and weight loss. Although the various laboratory studies pointed to the diagnosis of paraneoplastic pemphigus (PNP), the underlying neoplasm was not detected until 6 months later, when the patient developed shortness of...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00022-1
更新日期：2000-07-01 00:00:00
abstract：:Head and neck malignant tumors are classified according to the TNM staging system. The TNM system is a universally accepted, widely used, staging method. Its goals are to help clinicians and researchers to choose from treatment options, to give patients an estimate of their prognosis and to compare results of treatmen...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2008.05.022
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the new American Joint Committee on Cancer (AJCC) cancer staging manual (8th edition) in an independent cohort of patients surgically treated for oral squamous cell carcinoma in order to determine whether the upstaging of pT and pN classification was indicative of a worse prognosis. METHODS:A co...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.05.020
更新日期：2017-08-01 00:00:00
abstract：:The development of locoregional recurrence is the main reason for treatment failure in head and neck squamous cell carcinomas (HNSCC) and the remaining of tumor cells in surgical margins is associated with recurrence. Surgical margins are considered negative based on histologic assessment of the pathological specimen....
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.10.018
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.10.001
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:The programmed death pathway plays a role in persistent human papillomavirus (HPV) infection as well as in resistance to immune elimination during malignant progression. In this study, we examined PD-L1 expression by immunohistochemistry and tumour infiltrating lymphocytes (TIL) in 214 patients with orophary...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.03.012
更新日期：2019-05-01 00:00:00
abstract：:To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.04.014
更新日期：2005-10-01 00:00:00
