当前位置： SCI文献检索 > ORAL ONCOLOGY期刊下所有文献 > Determination of antibodies directed at EBV proteins expressed in both latent and lytic cycles in nasopharyngeal carcinoma.

Determination of antibodies directed at EBV proteins expressed in both latent and lytic cycles in nasopharyngeal carcinoma.

Abstract：

OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METHODS:Sixty healthy controls and 100 NPC patients treated with intensity-modulated radiation therapy were recruited for the study. Serial blood samples of NPC patients were collected before, during and after the treatment. The titers of antibodies directed at Rta (IgG), EA (IgG), VCA (IgA), and NA1 (IgA) were determined in duplicate by ELISA. RESULTS:Results showed that the combined tests of EA and Rta antibodies significantly improved the sensitivity from 89.0% for EA alone to 95%. For VCA or NA1 in combination with the EA test, it was revealed that either the increase of the specificity was minimal, or the decrease of the specificity was unacceptable. Rta, EA, VCA, and NA1 antibody titers in serial samples were followed from 53 patients of complete remission and 9 patients with recurrence or distal metastasis post the treatment for 2 years. However, the trend of antibody titers of Rta, VCA or NA1 in combination with EA failed to indicate a difference between patients with good and poor prognosis. CONCLUSION:Combined measurements of anti-Rta and anti-EA antibodies could significantly increase the sensitivity for the diagnosis of NPC while maintain a high specificity.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

doi

10.1016/j.oraloncology.2012.10.001

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

326-31

issue

4

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(12)00320-X

journal_volume

49

pub_type

杂志文章

相关文献

ORAL ONCOLOGY文献大全
  • Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens.

    abstract：OBJECTIVES:The introduction of intensity modulated radiation therapy (IMRT) has led to new possibilities in the treatment of head and neck cancer (HNC). Limited information is available on how this more advanced radiation technique affects the oral microflora. In a prospective study we assessed the effects of various a...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.05.005

    authors： Schuurhuis JM,Stokman MA,Witjes MJ,Langendijk JA,van Winkelhoff AJ,Vissink A,Spijkervet FK

    更新日期：2016-07-01 00:00:00

  • Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer.

    abstract：OBJECTIVES:To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC). METHODS:OPC treated with RT/CRT from 1/1/2000 to 5/31/2010 were reviewed. The natural course of DM were compared between HPV(+) and HPV(-) cohorts. RESU...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2012.07.015

    authors： Huang SH,Perez-Ordonez B,Weinreb I,Hope A,Massey C,Waldron JN,Kim J,Bayley AJ,Cummings B,Cho BC,Ringash J,Dawson LA,Siu LL,Chen E,Irish J,Gullane P,Hui A,Liu FF,Shen X,Xu W,O'Sullivan B

    更新日期：2013-01-01 00:00:00

  • Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis.

    abstract：INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2016.12.031

    authors： Mercadante V,Al Hamad A,Lodi G,Porter S,Fedele S

    更新日期：2017-03-01 00:00:00

  • Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma.

    abstract：:We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intratumoral (IT) PD-L1+ immune cells (ICs) or CD8+ infiltrating ICs are of prognostic value. Here we report the prognostic significance of these immune biomarkers in an independent validation c...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.104516

    authors： Young RJ,Bressel M,Porceddu S,Cernelc J,Savas P,Liu H,Urban D,Thai AA,Cooper C,Fua T,Neeson P,Rischin D,Solomon B

    更新日期：2020-02-01 00:00:00

  • Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma.

    abstract：OBJECTIVES:The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis. METHODS:Immunohistochemical NOTCH1 and HES1 expression was jointly evaluated and co...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.105003

    authors： Grilli G,Hermida-Prado F,Álvarez-Fernández M,Allonca E,Álvarez-González M,Astudillo A,Moreno-Bueno G,Cano A,García-Pedrero JM,Rodrigo JP

    更新日期：2020-11-01 00:00:00

  • Programmed death ligand 1 (PD-L1) expression and tumor microenvironment: Implications for patients with oral precancerous lesions.

    abstract：OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2017.03.006

    authors： Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

    更新日期：2017-05-01 00:00:00

  • Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.

    abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2008.05.019

    authors： Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

    更新日期：2009-03-01 00:00:00

  • Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma.

    abstract：BACKGROUND:The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104863

    authors： Liu C,Liao L,Wu G,Yan H,Chen X,Wang C,Zheng X,Zeng Z,Zhao Z,Wu D,Liu X

    更新日期：2020-06-27 00:00:00

  • Clinical benefits from endoscopy screening of esophageal second primary tumor for head and neck cancer patients: Analysis of a hospital-based registry.

    abstract：OBJECTIVES:Esophageal second primary tumors (SPTs) in head and neck cancer (HNC) patients is not uncommon. The impact of image-enhanced endoscopy (IEE) screening for esophageal SPT on the outcome of HNC patients has not been well clarified. METHODS AND METHODS:Patients with malignancies of the head and neck region and...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.06.038

    authors： Chung CS,Lo WC,Chen KC,Lin CL,Wen MH,Hsieh CH,Lin SC,Liao LJ

    更新日期：2019-09-01 00:00:00

  • Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head & neck cancer - a systematic review.

    abstract：PURPOSE:A systematic review to establish what evidence is available for swallowing outcomes following IMRT for head and neck cancer. METHODS:Online electronic databases were searched to identify papers published in English from January 1998 to December 2009. Papers were independently appraised by two reviewers for met...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2010.07.012

    authors： Roe JW,Carding PN,Dwivedi RC,Kazi RA,Rhys-Evans PH,Harrington KJ,Nutting CM

    更新日期：2010-10-01 00:00:00

  • Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors.

    abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.06.012

    authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

    更新日期：2006-01-01 00:00:00

  • EB-D fibronectin expression in squamous cell carcinoma of the head and neck.

    abstract：:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2004.07.003

    authors： Mhawech P,Dulguerov P,Assaly M,Ares C,Allal AS

    更新日期：2005-01-01 00:00:00

  • Modulation of thyroid hormone-dependent Na+,K(+)-ATPase induction in cultured human submandibular gland cell lines, HSG cells.

    abstract：:The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(98)00124-9

    authors： Kurihara K,Tajima Y,Kawasaki M,Ueha T

    更新日期：1999-07-01 00:00:00

  • Current attitudes of head and neck oncologists in the United Kingdom to induction chemotherapy for locally advanced head and neck cancer: a survey of centres participating in a national randomised controlled trial.

    abstract：OBJECTIVES:Induction chemotherapy (IC) followed by chemoradiation (CRT) for locally advanced squamous cell head and neck cancer (SCCHN) remains controversial in the absence of clear evidence to define its role. As part of a prospective, randomised, multicentre study of CRT for stage III/IV laryngeal/hypopharyngeal canc...

    journal_title：Oral oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.oraloncology.2013.10.012

    authors： Gujral DM,Piercy D,Morden JP,Emson M,Hall E,Miah AB,Bhide SA,Newbold KL,Harrington KJ,Nutting CM

    更新日期：2014-02-01 00:00:00

  • Comparative study of sentinel lymph node biopsy in clinically N0 oral tongue squamous cell carcinoma: Long-term oncologic outcomes between validation and application phases.

    abstract：OBJECTIVE:This study tested the long-term outcomes of sentinel lymph node biopsy (SLNB) for oral tongue squamous cell carcinoma (SCC) during the transition from validation to application phase. MATERIALS AND METHODS:Sensitivity, negative predictive value (NPV), neck control rate, disease-specific survival (DSS), disea...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2015.07.007

    authors： Chung MK,Lee GJ,Choi N,Cho JK,Jeong HS,Baek CH

    更新日期：2015-10-01 00:00:00

  • Loss of VHL expression contributes to epithelial-mesenchymal transition in oral squamous cell carcinoma.

    abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.06.007

    authors： Zhang S,Zhou X,Wang B,Zhang K,Liu S,Yue K,Zhang L,Wang X

    更新日期：2014-09-01 00:00:00

  • miR-29b suppresses proliferation, migration, and invasion of tongue squamous cell carcinoma through PTEN-AKT signaling pathway by targeting Sp1.

    abstract：OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.07.010

    authors： Jia LF,Huang YP,Zheng YF,Lyu MY,Wei SB,Meng Z,Gan YH

    更新日期：2014-11-01 00:00:00

  • RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers.

    abstract：:Mutations in histone modifying enzymes and histone variants were identified in multiple cancers in The Cancer Genome Atlas (TCGA) studies. However, very little progress and understanding has been made in identifying the contribution of epigenetic factors in head and neck squamous cell carcinoma (HNSCC). Here, we repor...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104930

    authors： Lin D,Lin B,Bhanot H,Riou R,Abt NB,Rajagopal J,Saladi SV

    更新日期：2020-12-01 00:00:00

  • Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base.

    abstract：OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.02.011

    authors： Amini A,Jasem J,Jones BL,Robin TP,McDermott JD,Bhatia S,Raben D,Jimeno A,Bowles DW,Karam SD

    更新日期：2016-05-01 00:00:00

  • Complementary serum test of antibodies to Epstein-Barr virus nuclear antigen-1 and early antigen: a possible alternative for primary screening of nasopharyngeal carcinoma.

    abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2007.10.003

    authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

    更新日期：2008-08-01 00:00:00

  • Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

    abstract：INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2018.10.010

    authors： Wolf GT,Winter W,Bellile E,Nguyen A,Donnelly CR,McHugh JB,Thomas D,Amlani L,Rozek L,Lei YL,Head and Neck SPORE Program.

    更新日期：2018-12-01 00:00:00

  • Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma.

    abstract：:The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-c...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2008.03.008

    authors： Siriwardena BS,Kudo Y,Ogawa I,Tilakaratne WM,Takata T

    更新日期：2009-02-01 00:00:00

  • Imaging of oral cavity cancer.

    abstract：:Despite many advances in surgical techniques, technology, radiation therapy, and chemotherapy, survival rates for head and neck cancer (HNCa) have not improved significantly in decades, with many patients being diagnosed at advanced disease stages. Adequate assessment of oral cavity malignancies is critical for approp...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2006.01.010

    authors： Rumboldt Z,Day TA,Michel M

    更新日期：2006-10-01 00:00:00

  • Transoral robotic total laryngopharyngectomy and free jejunal flap reconstruction for hypopharyngeal cancer.

    abstract：BACKGROUND:To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach. MATERIAL AND METHODS:A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TOR...

    journal_title：Oral oncology

    pub_type： 信件

    doi：10.1016/j.oraloncology.2017.06.028

    authors： Chan JYW,Chan RCL,Chow VLY,Tsang RKY,Wong STS,Wei WI

    更新日期：2017-09-01 00:00:00

  • Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.

    abstract：:Adenoid cystic carcinoma (ACC) of the salivary glands exhibits persistent growth, invasion and metastasis. Chromosome 11q13 amplification is a frequent event associated with tumor progression in a number of carcinomas and is associated with poor prognosis. Two genes within the 11q13 amplicon that are overexpressed as ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2006.09.007

    authors： Greer RO Jr,Said S,Shroyer KR,Marileila VG,Weed SA

    更新日期：2007-09-01 00:00:00

  • Immediate knowledge increase from an oral cancer information leaflet in patients attending a primary health care facility: a randomised controlled trial.

    abstract：:The aim was to determine the immediate influence of a validated patient information leaflet (PIL) on oral cancer and knowledge in primary care attenders. Participants were patients (n=800) attending their primary health care provider from 14 general practices (eight dental and six medical) in the north west of England...

    journal_title：Oral oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1368-8375(00)00069-5

    authors： Humphris GM,Ireland RS,Field EA

    更新日期：2001-01-01 00:00:00

  • Podoplanin expression in oral leukoplakia: tumorigenic role.

    abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2013.02.008

    authors： de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

    更新日期：2013-06-01 00:00:00

  • Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation.

    abstract：:The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005. The accuracy of the new system for predicting malignant transformation was also assessed. Ninety-six consecutive oral epithelial dyspl...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.12.014

    authors： Kujan O,Oliver RJ,Khattab A,Roberts SA,Thakker N,Sloan P

    更新日期：2006-11-01 00:00:00

  • Establishment of syngeneic murine model for oral cancer therapy.

    abstract：:Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment of murine OSCC cell lines and syngeneic mode...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.06.026

    authors： Chen YF,Chang KW,Yang IT,Tu HF,Lin SC

    更新日期：2019-08-01 00:00:00

  • The lip-splitting mandibulotomy: aesthetic and functional outcomes.

    abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2010.05.006

    authors： Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

    更新日期：2010-08-01 00:00:00