RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers.

abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

journal_title：Oral oncology

authors： Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...

journal_title：Oral oncology

authors： Scher ED,Romesser PB,Chen C,Ho F,Wuu Y,Sherman EJ,Fury MG,Wong RJ,McBride S,Lee NY,Riaz N

更新日期：2015-07-01 00:00:00

abstract：:Immunotherapy (IO) with anti-PD1 inhibitors is available for the treatment of recurrent/metastatic squamous cell carcinomas of the head and neck (SCCHD) since 2016. Both nivolumab and pembrolizumab were tested in phase 3 randomized trials in adults progressing on or after platinum-based therapy and were found to confe...

journal_title：Oral oncology

authors： Kokkali S,Ntokou A,Drizou M,Perdikari K,Makaronis P,Katsarou E,Koufopoulos N,Tzovaras A,Ardavanis A

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:In shared decision making it is important to adequately, timely and actively involve patients in treatment decisions. Sharing prognostic information can be of key importance. This study describes whether and how prognostic information on life expectancy is included during communication on diagnosis and treat...

journal_title：Oral oncology

authors： Dronkers EAC,Hoesseini A,de Boer MF,Offerman MPJ

更新日期：2018-09-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS:Detailed, type-specific HPV antibody responses were analyzed by ...

journal_title：Oral oncology

authors： Broglie MA,Jochum W,Michel A,Waterboer T,Foerbs D,Schoenegg R,Stoeckli SJ,Pawlita M,Holzinger D

更新日期：2017-07-01 00:00:00

abstract：:To assess the prognostic value of apoptosis, proliferation and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Between 1985 and 1995, a total of 82 patients with 84 tumors were entered onto the study. Forty-two primary tumors (50%) involved the t...

journal_title：Oral oncology

authors： Grabenbauer GG,Suckorada O,Niedobitek G,Rödel F,Iro H,Sauer R,Rödel C,Schultze-Mosgau S,Distel L

更新日期：2003-07-01 00:00:00

abstract：:Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

journal_title：Oral oncology

authors： Piattelli A,Rubini C,Fioroni M,Iezzi G

更新日期：2000-09-01 00:00:00

abstract：:The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...

journal_title：Oral oncology

authors： Brouwer J,Senft A,de Bree R,Comans EF,Golding RP,Castelijns JA,Hoekstra OS,Leemans CR

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:The submental artery island flap (SIF) has recently been described in temporal bone defects. At our institution we have broadened the application of the SIF and modified the harvest technique for complex lateral facial and skull base defects. Our primary aim is to evaluate the outcomes of patients undergoing...

journal_title：Oral oncology

authors： Patel AV,Thuener JE,Clancy K,Ascha M,Manzoor NF,Zender CA

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...

journal_title：Oral oncology

authors： Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC...

journal_title：Oral oncology

authors： Shaikh MH,Idris A,Johnson NW,Fallaha S,Clarke DTW,Martin D,Morgan IM,Gabrielli B,McMillan NAJ

更新日期：2018-11-01 00:00:00

abstract：:Ameloblastoma is a rare human disease of benign neoplasm odontogenic tumor with a lower prevalence but higher recurrence rate. Etiology of ameloblastoma is not fully understood thus lacks implementation of curative treatments. One of the proposed models of evolution of ameloblastoma is related to alteration in DNA dam...

journal_title：Oral oncology

authors： Toprani SM

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

journal_title：Oral oncology

authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carrie...

journal_title：Oral oncology

authors： Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

更新日期：2013-09-01 00:00:00

abstract：:Prophylactic internal fixation (PIF), with a bone plate in either the anterior (over the section defect) or posterior (on intact cortex) position, has substantially reduced the incidence of fracture at the donor site of the radial osteocutaneous free flap. This study uses the sheep tibia model to compare the effective...

journal_title：Oral oncology

authors： Avery CM,Skidmore M,Peden A,Pan J

更新日期：2011-04-01 00:00:00

abstract：:A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...

journal_title：Oral oncology

authors： Ma G,Ikeda H,Inokuchi T,Sano K

更新日期：1999-01-01 00:00:00

abstract：:Sebaceous adenoma is a tumour only rarely located in the oral cavity. Less than 10 cases have been reported. Sebaceous adenoma represents 0.5-0.7% of all monomorphic adenomas. Sebaceous adenoma is mainly constituted by two types of cells, undifferentiated peripheral basaloid cells and cells showing different degrees o...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to evaluate the reliability and utility of a histoculture drug response assay (HDRA) for treatment of squamous cell carcinoma in the oral cavity. Nineteen patients with squamous cell carcinoma of the oral cavity were assessed. Tumor tissue samples were histocultured on Gelfoam sponge gels in ...

journal_title：Oral oncology

authors： Ariyoshi Y,Shimahara M,Tanigawa N

更新日期：2003-10-01 00:00:00

abstract：:The aim of this study is to assess the impact of prognostic factors in patients with locoregionally advanced nasopharyngeal cancer (NPC), WHO type II-III, treated with two different radiation therapy (RT) schedules: standard radiation therapy (SRT), and accelerated hyperfractionated radiation therapy (HART), with or w...

journal_title：Oral oncology

authors： Franchin G,Vaccher E,Talamini R,Gobitti C,Minatel E,Politi D,Sartor G,Trovò MG,Barzan L

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed a...

journal_title：Oral oncology

authors： Camille N,Rozehnal J,Roy E,Uczkowski D,Olson A,Genden E,Teng M,Bakst R,Gupta V,Posner M,Misiukiewicz K

更新日期：2017-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

journal_title：Oral oncology

authors： Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

journal_title：Oral oncology

authors： El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

更新日期：2019-03-01 00:00:00

abstract：:The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. FHIT is frequently abnormal in solid tumours including those of the upper aerodigestive tract (UAT) and has therefore been proposed as a tumour-suppressor gene. T...

journal_title：Oral oncology

authors： Pateromichelakis S,Lee G,Langdon JD,Partridge M

更新日期：2000-03-01 00:00:00

abstract：:We evaluated the prognostic significance of p34cdc2 expression in 50 tongue squamous cell carcinomas (SCC) using immunohistochemical methods. The p34cdc2 protein was expressed in 33 cases of 50 tumor tissues (66.0%), compared with 15 cases of 42 controlled epithelia (35.7%). The expression of p34cdc2 was significantly...

journal_title：Oral oncology

authors： Wada S,Yue L,Furuta I

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:We evaluated the effects of three-dimensional virtual planning and the use of a plate-embedded surgical guide in mandibular reconstruction with microvascular fibula flaps. MATERIALS AND METHODS:We retrospectively reviewed 35 patients who underwent primary mandibular reconstruction with a free fibula flap. T...

journal_title：Oral oncology

authors： Bao T,He J,Yu C,Zhao W,Lin Y,Wang H,Liu J,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:Human beta-defensins (hBDs) are small, cationic antimicrobial peptides produced by oral and other mucosal epithelia. More recently, hBDs have been shown to regulate adaptive immunity. In this study, we provide new information about the potential role of hBD-3 in the progression of oral cancer. In normal human oral epi...

journal_title：Oral oncology

authors： Kawsar HI,Weinberg A,Hirsch SA,Venizelos A,Howell S,Jiang B,Jin G

更新日期：2009-08-01 00:00:00

abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

journal_title：Oral oncology

authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs1799752) varian...

journal_title：Oral oncology

authors： Liu YT,Lin LW,Chen CY,Wang CP,Liu HP,Houng JY,Chung FM,Shieh TY

更新日期：2012-12-01 00:00:00

abstract：:Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

journal_title：Oral oncology

authors： Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

更新日期：2006-05-01 00:00:00