Vascular priming enhances chemotherapeutic efficacy against head and neck cancer.

Abstract:

PURPOSE:The need to improve chemotherapeutic efficacy against head and neck squamous cell carcinomas (HNSCC) is well recognized. In this study, we investigated the potential of targeting the established tumor vasculature in combination with chemotherapy in head and neck cancer. METHODS:Experimental studies were carried out in multiple human HNSCC xenograft models to examine the activity of the vascular disrupting agent (VDA) 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in combination with chemotherapy. Multimodality imaging (magnetic resonance imaging, bioluminescence) in conjunction with drug delivery assessment (fluorescence microscopy), histopathology and microarray analysis was performed to characterize tumor response to therapy. Long-term treatment outcome was assessed using clinically-relevant end points of efficacy. RESULTS:Pretreatment of tumors with VDA prior to administration of chemotherapy increased intratumoral drug delivery and treatment efficacy. Enhancement of therapeutic efficacy was dependent on the dose and duration of VDA treatment but was independent of the chemotherapeutic agent evaluated. Combination treatment resulted in increased tumor cell kill and improvement in progression-free survival and overall survival in both ectopic and orthotopic HNSCC models. CONCLUSION:Our results show that preconditioning of the tumor microenvironment with an antivascular agent primes the tumor vasculature and results in enhancement of chemotherapeutic delivery and efficacy in vivo. Further investigation into the activity of antivascular agents in combination with chemotherapy against HNSCC is warranted.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Folaron M,Kalmuk J,Lockwood J,Frangou C,Vokes J,Turowski SG,Merzianu M,Rigual NR,Sullivan-Nasca M,Kuriakose MA,Hicks WL Jr,Singh AK,Seshadri M

doi

10.1016/j.oraloncology.2013.06.011

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

893-902

issue

9

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(13)00631-3

journal_volume

49

pub_type

杂志文章
  • Comorbidity and diagnostic delay in cancer of the larynx, tongue and pharynx.

    abstract::Comorbidity and diagnostic delay are independent prognostic factors in head and neck cancer, most notably in laryngeal cancer. We investigated their inter-relationship and their relative significance in survival of three different head and neck cancers. A population-based retrospective cohort of 221 patients with canc...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2008.10.012

    authors: Teppo H,Alho OP

    更新日期:2009-08-01 00:00:00

  • Tooth extraction in patients on zoledronic acid therapy.

    abstract:OBJECTIVES:Surgical management of patients following zoledronic acid therapy is particularly difficult, since the dental extraction is the main cause of BRONJ. METHODS:A case-control study was conducted on 176 patients treated with intravenous (IV) bisphosphonates for oncologic pathologies who also underwent dental ex...

    journal_title:Oral oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.oraloncology.2012.03.009

    authors: Mozzati M,Arata V,Gallesio G

    更新日期:2012-09-01 00:00:00

  • Weekly and 3-weekly cisplatin concurrent with intensity-modulated radiotherapy in locally advanced head and neck squamous cell cancer.

    abstract::In loco-regionally advanced head and neck squamous cell cancer (HNSCC), concurrent 3-weekly cisplatin improves overall survival (OS) compared to radiotherapy alone, but is often associated with renal toxicity. The use of radiotherapy with accelerated fractionation schedules has been reported to improve survival but it...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.10.005

    authors: Espeli V,Zucca E,Ghielmini M,Giannini O,Salatino A,Martucci F,Richetti A

    更新日期:2012-03-01 00:00:00

  • The impact of an educational video about radiotherapy and its toxicities in head and neck cancer patients. Evaluation of patients' understanding, anxiety, depression, and quality of life.

    abstract:OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104712

    authors: Fernandes DT,Prado-Ribeiro AC,Markman RL,Morais K,Moutinho K,Tonaki JO,Brandão TB,Rivera C,Santos-Silva AR,Lopes MA

    更新日期:2020-07-01 00:00:00

  • Comparison of different lymph node staging systems in patients with positive lymph nodes in oral squamous cell carcinoma.

    abstract:OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.105146

    authors: Lin NC,Su IH,Hsu JT,Chang YJ,Tsai KY

    更新日期:2021-01-16 00:00:00

  • Pemetrexed in head and neck cancer: a systematic review.

    abstract::Pemetrexed has been evaluated as a novel chemotherapeutic for head and neck cancer (HNC). In this review, we examined the efficacy and tolerability of pemetrexed in patients with HNC. Relevant English-language literature was identified via PubMed and a review of published abstracts from the American Society of Clinica...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2013.01.007

    authors: Argiris A,Pennella E,Koustenis A,Hossain AM,Obasaju CK

    更新日期:2013-06-01 00:00:00

  • Overexpression of human beta-defensin-3 in oral dysplasia: potential role in macrophage trafficking.

    abstract::Human beta-defensins (hBDs) are small, cationic antimicrobial peptides produced by oral and other mucosal epithelia. More recently, hBDs have been shown to regulate adaptive immunity. In this study, we provide new information about the potential role of hBD-3 in the progression of oral cancer. In normal human oral epi...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2008.10.016

    authors: Kawsar HI,Weinberg A,Hirsch SA,Venizelos A,Howell S,Jiang B,Jin G

    更新日期:2009-08-01 00:00:00

  • The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer.

    abstract::The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2009.07.015

    authors: Chen MK,Chiou HL,Su SC,Chung TT,Tseng HC,Tsai HT,Yang SF

    更新日期:2009-12-01 00:00:00

  • Long-term speech and swallowing function after primary resection and sentinel node biopsy for early oral squamous cell carcinoma.

    abstract:OBJECTIVES:Analysis of long-term speech and swallowing function and subjective quality of life (QOL) after primary resection and sentinel node biopsy (SNB) in patients with early stage (cT1/T2) oral squamous cell carcinomas (OSCC). MATERIAL AND METHODS:Eighty-one consecutive patients treated primarily by transoral res...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.12.027

    authors: Romer CAE,Broglie Daeppen MA,Mueller M,Huber GF,Guesewell S,Stoeckli SJ

    更新日期:2019-02-01 00:00:00

  • Obturators versus flaps after maxillary oncological ablation: A systematic review and best evidence synthesis.

    abstract::Maxillary defects can be resolved by prosthetic obturation, autologous tissue reconstruction, or a combination of both. However, there is still controversy in the selection of the optimal approach. Therefore, the aim of this study was to systematically review evidences comparing the performance of obturators and flaps...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.05.019

    authors: Cao Y,Yu C,Liu W,Miao C,Han B,Yang J,Li L,Li C

    更新日期:2018-07-01 00:00:00

  • Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma.

    abstract:OBJECTIVES:The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis. METHODS:Immunohistochemical NOTCH1 and HES1 expression was jointly evaluated and co...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.105003

    authors: Grilli G,Hermida-Prado F,Álvarez-Fernández M,Allonca E,Álvarez-González M,Astudillo A,Moreno-Bueno G,Cano A,García-Pedrero JM,Rodrigo JP

    更新日期:2020-11-01 00:00:00

  • Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers?

    abstract:OBJECTIVES:To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution. PATIENTS AND METHODS:An Institutional Review Board (IRB)-approved...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.01.013

    authors: Gupta P,Migliacci JC,Montero PH,Zanoni DK,Shah JP,Patel SG,Ganly I

    更新日期:2018-03-01 00:00:00

  • Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer.

    abstract:OBJECTIVES:The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significanc...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.01.014

    authors: Kuk SK,Yoon HJ,Hong SD,Hong SP,Lee JI

    更新日期:2016-04-01 00:00:00

  • Translational research in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is well known to be a viral driven malignancy. Despite high loco-regional control rate with modern radiotherapy, distant metastasis remains as a major threat to the patients highlighting the importance of effective systemic therapy. Recent advances in the understanding of tumor biology, host c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2013.11.005

    authors: Chiang AK,Mak NK,Ng WT

    更新日期:2014-05-01 00:00:00

  • A novel algorithm for lymph node status prediction of oral cancer before surgery.

    abstract::An algorithm was developed to predict lymph node metastasis in patients with oral squamous cell carcinoma. To improve the diagnostic accuracy of lymph node status, we suggest a criterion for the prediction of lymph node status by combining clinical and molecular information. To develop a model to predict lymph node me...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.07.017

    authors: Kim KY,Cha IH

    更新日期:2011-11-01 00:00:00

  • Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma.

    abstract::The Wnt pathway is involved in carcinogenesis and three regulatory genes of the Wnt pathway, APC (adenomatous polyposis coli), beta-catenin and Axin are frequently mutated in some primary human cancers. This study was conducted to clarify the relation of beta-catenin accumulation and the mutation of the CTNNB1 (beta-c...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2008.03.008

    authors: Siriwardena BS,Kudo Y,Ogawa I,Tilakaratne WM,Takata T

    更新日期:2009-02-01 00:00:00

  • 'Doing as little as possible and as much as necessary' - Oncological efficacy of marginal mandibulectomy in resection of oral cavity cancers.

    abstract:BACKGROUND:In carefully selected oral cavity cancers, marginal mandibulectomy is an adequate procedure which achieves good disease control adhering to the principle of "doing as little as possible and as much as necessary". METHODOLOGY:This was a retrospective study done by reviewing the medical records of all patient...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.05.026

    authors: Suresh S,Thomas S,Janardhan D,Patil S,George NA,Varghese BT,Iype EM,Rafi M,George CK

    更新日期:2019-08-01 00:00:00

  • The lip-splitting mandibulotomy: aesthetic and functional outcomes.

    abstract::To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.05.006

    authors: Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

    更新日期:2010-08-01 00:00:00

  • Unilateral endoscopic resection with transnasal craniectomy for sinonasal intestinal-type adenocarcinoma: A bi-institutional case-control study on 54 patients.

    abstract:OBJECTIVES:Intestinal-type adenocarcinoma (ITAC) of the ethmoid mostly affects patients exposed to wood dust and has been traditionally treated with bilateral resection. The aim of the present study was to validate unilateral endoscopic resection with transnasal craniectomy (uERTC) in selected ITACs. MATERIALS AND MET...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.oraloncology.2018.10.027

    authors: Schreiber A,Ferrari M,Mattavelli D,Rampinelli V,Taboni S,Vural A,Bignami M,Castelnuovo P,Nicolai P

    更新日期:2018-12-01 00:00:00

  • Mucositis: The impact, biology and therapeutic opportunities of oral mucositis.

    abstract::The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2009.08.006

    authors: Sonis ST

    更新日期:2009-12-01 00:00:00

  • Dysplasia/neoplasia surveillance in oral lichen planus patients: a description of clinical criteria adopted at a single centre and their impact on prognosis.

    abstract::The concept of dysplasia/neoplasia surveillance has been applied to long-standing conditions associated with an increased risk of cancer. Although still controversial, periodic direct clinical examination as well as endoscopic techniques are currently performed in patients with inflammatory bowel diseases, Barrett's e...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2005.11.022

    authors: Mignogna MD,Fedele S,Lo Russo L

    更新日期:2006-09-01 00:00:00

  • Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer.

    abstract::We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.01.010

    authors: Nguyen NP,Ceizyk M,Vos P,Vinh-Hung V,Davis R,Desai A,Abraham D,Krafft SP,Jang S,Watchman CJ,Ewell L,Hamilton R,Smith-Raymond L

    更新日期:2010-04-01 00:00:00

  • Prognostic significance of p34cdc2 expression in tongue squamous cell carcinoma.

    abstract::We evaluated the prognostic significance of p34cdc2 expression in 50 tongue squamous cell carcinomas (SCC) using immunohistochemical methods. The p34cdc2 protein was expressed in 33 cases of 50 tumor tissues (66.0%), compared with 15 cases of 42 controlled epithelia (35.7%). The expression of p34cdc2 was significantly...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(03)00146-5

    authors: Wada S,Yue L,Furuta I

    更新日期:2004-02-01 00:00:00

  • Silencing Met receptor tyrosine kinase signaling decreased oral tumor growth and increased survival of nude mice.

    abstract:OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2013.10.014

    authors: Tao X,Hill KS,Gaziova I,Sastry SK,Qui S,Szaniszlo P,Fennewald S,Resto VA,Elferink LA

    更新日期:2014-02-01 00:00:00

  • Utilization of a pre-bent plate-positioning surgical guide system in precise mandibular reconstruction with a free fibula flap.

    abstract:OBJECTIVES:We evaluated the effects of three-dimensional virtual planning and the use of a plate-embedded surgical guide in mandibular reconstruction with microvascular fibula flaps. MATERIALS AND METHODS:We retrospectively reviewed 35 patients who underwent primary mandibular reconstruction with a free fibula flap. T...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.11.011

    authors: Bao T,He J,Yu C,Zhao W,Lin Y,Wang H,Liu J,Zhu H

    更新日期:2017-12-01 00:00:00

  • (18)FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis.

    abstract::We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.oraloncology.2011.04.021

    authors: Xu GZ,Guan DJ,He ZY

    更新日期:2011-07-01 00:00:00

  • A novel scoring model to predict benefit of additional induction chemotherapy to concurrent chemoradiotherapy in stage II-IVa nasopharyngeal carcinoma.

    abstract:OBJECTIVES:Induction chemotherapy (IC) is gaining recognition for the treatment of nasopharyngeal carcinoma (NPC). We aimed to develop a model to predict benefit from additional IC to concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS:From an NPC-specific database, 7413 patients with stage II-IVa disease who r...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2018.10.007

    authors: Peng L,Chen YP,Xu C,Tang LL,Chen L,Lin AH,Liu X,Sun Y,Ma J

    更新日期:2018-11-01 00:00:00

  • Evaluation of the immunogenicity of ALDH(high) human head and neck squamous cell carcinoma cancer stem cells in vitro.

    abstract:OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.05.013

    authors: Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

    更新日期:2016-08-01 00:00:00

  • Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients.

    abstract:OBJECTIVES:The advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients' clinical characteristics and circulating HPV DNA detection in the blood of patients wit...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.12.002

    authors: Mazurek AM,Rutkowski T,Fiszer-Kierzkowska A,Małusecka E,Składowski K

    更新日期:2016-03-01 00:00:00

  • Vocal process granuloma - A result of long-term observation in 53 patients.

    abstract::Vocal process granulomas are benign lesions involved in the healing of posterior glottis injuries. Here, we report the results of our conservative treatment of vocal process granulomas. Fifty-three patients with 54 occurrences of granulomas between 1998 and 2007 were enrolled. All patients were observed without surgic...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2009.01.008

    authors: Wang CP,Ko JY,Wang YH,Hu YL,Hsiao TY

    更新日期:2009-09-01 00:00:00