Abstract：
:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if primary studies are heterogeneous, the between-study variance is higher than zero, and its effect must be taken into account in choosing the weighting scheme. The robustness of the estimates was assessed by means of sensitivity analyses. Including 23 primary studies from all over the world published between 1986 and 2002, the point estimates were 1.49% (inverse variance, 95% confidence interval 1.42%-1.56%) and 2.60% (random effect, 95% confidence interval 1.72%-2.74%). The high between-study heterogeneity and the sensitivity analyses suggested that the second estimate was more reliable. Leukoplakia was significantly more prevalent among males (prevalence ratio 3.22), but no difference was found between geographical areas and between younger and older adults. Using these data, the crude annual oral cancer incidence rate attributable to leukoplakia would be between 6.2 and 29.1 per 100000, thus suggesting that the global number of oral cancer cases is probably underreported.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Petti Sdoi
10.1016/s1368-8375(03)00102-7subject
Has Abstractpub_date
2003-12-01 00:00:00pages
770-80issue
8eissn
1368-8375issn
1879-0593pii
S1368837503001027journal_volume
39pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract：OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.04.003
更新日期：2017-06-01 00:00:00
abstract：:We analyzed the T cell receptor (TCR) gammadelta gene repertoire in peripheral blood and tumor compartment of oral cancer (OC) patients before and after stimulation with heat shock proteins (hsp), which are known ligands for gammadelta T cells. Clonal TCR gamma and delta gene rearrangements in lymphocytes from tumor c...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2004.08.007
更新日期：2005-02-01 00:00:00
abstract：:It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2008.05.015
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically a...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.09.014
更新日期：2013-03-01 00:00:00
abstract：:Despite many advances in surgical techniques, technology, radiation therapy, and chemotherapy, survival rates for head and neck cancer (HNCa) have not improved significantly in decades, with many patients being diagnosed at advanced disease stages. Adequate assessment of oral cavity malignancies is critical for approp...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2006.01.010
更新日期：2006-10-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) is often diagnosed at advanced stages and is associated with poor survival rates. Increasing evidence suggests that microRNAs (miRNAs) present in liquid biopsies could be potential biomarkers for non-invasive OSCC diagnosis. Here, we performed a comprehensive meta-analysis to evalua...
journal_title：Oral oncology
pub_type： 杂志文章,meta分析
doi：10.1016/j.oraloncology.2019.104465
更新日期：2019-12-01 00:00:00
abstract：:Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research fo...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2014.09.005
更新日期：2014-12-01 00:00:00
abstract：:p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00051-7
更新日期：1999-01-01 00:00:00
abstract：:We hope to establish a new readmission prediction score for patients with head and neck cancer (HNC) after major cancer surgery. A retrospective cohort study was conducted from the clinical and cancer registry data at Kaohsiung Veterans General Hospital. We included the data of patients with newly diagnosed HNC who un...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104772
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. MATERIALS AND METHODS:All patients diagnosed with OSCC in E...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.105031
更新日期：2020-12-01 00:00:00
abstract：:Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas (OSCC). We evaluated the presence of myofibroblasts in OSCC and determined whether their presence is associated with clinicop...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.07.001
更新日期：2008-05-01 00:00:00
abstract：:Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00118-3
更新日期：1999-05-01 00:00:00
abstract：:To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.04.014
更新日期：2005-10-01 00:00:00
abstract：:In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol,...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(03)00140-4
更新日期：2004-01-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2015.02.092
更新日期：2015-05-01 00:00:00
abstract：:Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(99)00023-8
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.02.004
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVES:To characterize specific serious toxicities of reRT with intensity modulated radiation therapy (IMRT) for squamous cell carcinoma of the head and neck (SCCHN) and identify treatment-related predictors of toxicity for patient counseling and decision-making. MATERIALS/METHODS:75 consecutive patients with recu...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.08.012
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2013.10.014
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer cell lines that have remained uncharacterized despite being used as model systems for decades. MATERIALS AND METHODS:We performed exome sequencing on 14 oral cavity UM-SCC cell lines and denote the mutational profile of each line. ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.10.031
更新日期：2018-12-01 00:00:00
abstract：:The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00020-8
更新日期：2000-07-01 00:00:00
abstract：:Osteonecrosis of the jaw (ONJ) is an adverse event that has been reported in patients receiving cancer treatment regimens, including bevacizumab, bisphosphonates, and denosumab. We performed a preliminary open label, prospective phase I-II study in patients treated with bisphosphonate to evaluate the treatment effect ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.01.002
更新日期：2011-03-01 00:00:00
abstract：:The identification of the proliferative activity in tumours may be useful to predict the biological behaviour of different lesions. Proliferating cell nuclear antigen (PCNA) has been used for the evaluation of the proliferative ability of many lesions. In this study 22 ameloblastomas (4 follicular, 5 plexiform, 4 acan...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00027-x
更新日期：1998-09-01 00:00:00
abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2009.08.006
更新日期：2009-12-01 00:00:00
abstract：:Retinoids are the natural and synthetic derivatives of vitamin A. Epidemiological studies indicate that a low intake of vitamin A is associated with an increased risk of squamous cancer. In vitro studies on cancer cells show that exposure to retinoids results in the inhibition of growth, by blocking the cell cycle or ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s1368-8375(01)00118-x
更新日期：2002-09-01 00:00:00
abstract：:We investigated the knowledge and behaviors of a random sample of 500 primary care physicians (PCPs) regarding oral cancer in Calabria (Italy). 87.6% and 64% indicated tobacco and alcohol use as risk factors, only 31.5% and 2.8% having a prior oral cancer lesion and older age. 60.9% knew that squamous-cell carcinoma i...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2003.10.001
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.03.014
更新日期：2016-06-01 00:00:00
abstract：:Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of H...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2011.02.009
更新日期：2011-04-01 00:00:00
abstract：:Our previous study demonstrated that overexpression of Id-1 (inhibitor of differentiation/DNA binding) was associated with lymphatic metastasis in human oral squamous cell carcinoma (OSCC). In this study, we further unveiled the association of Id-1 with vascular endothelial growth factor-C (VEGF-C) and peritumoral lym...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.10.012
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.12.004
更新日期：2015-03-01 00:00:00
