Heat shock protein induced TCR gammadelta gene rearrangements in patients with oral cancer.

abstract：OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...

journal_title：Oral oncology

authors： Jia LF,Huang YP,Zheng YF,Lyu MY,Wei SB,Meng Z,Gan YH

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:Prior studies suggest that oxaliplatin is unique among platinum chemotherapy drugs in its ability to enhance anti-tumor immunity, but the immune mechanisms of different platinum chemotherapy drugs have not been previously compared in preclinical models of head and neck squamous cell carcinoma (HNSCC). MATER...

journal_title：Oral oncology

authors： Park SJ,Ye W,Xiao R,Silvin C,Padget M,Hodge JW,Van Waes C,Schmitt NC

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to estimate the relations between hypoxia inducible factor-1alpha (HIF-1alpha) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study...

journal_title：Oral oncology

authors： Chen MK,Chiou HL,Su SC,Chung TT,Tseng HC,Tsai HT,Yang SF

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...

journal_title：Oral oncology

authors： Wolf GT,Winter W,Bellile E,Nguyen A,Donnelly CR,McHugh JB,Thomas D,Amlani L,Rozek L,Lei YL,Head and Neck SPORE Program.

更新日期：2018-12-01 00:00:00

abstract：:The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...

journal_title：Oral oncology

authors： Bloching M,Hofmann A,Lautenschläger C,Berghaus A,Grummt T

更新日期：2000-11-01 00:00:00

abstract：:The inactivation of tumor suppressor gene (TSG) is important during multistage carcinogenesis. The p53 TSG is frequently mutated in oral squamous cell carcinomas. These mutations can serve as very specific markers for the presence of tumor cells in a background of normal cells. In this study, 10 oral squamous cell car...

journal_title：Oral oncology

authors： Liao PH,Chang YC,Huang MF,Tai KW,Chou MY

更新日期：2000-05-01 00:00:00

abstract：:To encourage the public to attend and accept oral cancer screening, further understanding is required of the ability of structured information to alter patient knowledge and risk perceptions. Previous work has shown the benefit of written information for those at high risk of oral cancer, especially for tobacco smoker...

journal_title：Oral oncology

authors： Humphris GM,Freeman R,Clarke HM

更新日期：2004-10-01 00:00:00

abstract：:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

journal_title：Oral oncology

authors： Bernstein JM,Homer JJ,West CM

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of the apparent diffusion coefficient (ADC) for response prediction and response monitoring, less is known about the biological background of ADC. In the tumor micr...

journal_title：Oral oncology

authors： Swartz JE,Driessen JP,van Kempen PMW,de Bree R,Janssen LM,Pameijer FA,Terhaard CHJ,Philippens MEP,Willems S

更新日期：2018-02-01 00:00:00

abstract：:Keratins have been extensively studied in tissues and cultured keratinocytes but limited information is available on epithelia reconstructed in vitro. The aim of this study was to examine keratin expression in organotypic epithelia with normal (NOK), immortalized (SVpgC2a) and malignant (SqCC/Y1) human buccal cells. O...

journal_title：Oral oncology

authors： Hansson A,Bloor BK,Haig Y,Morgan PR,Ekstrand J,Grafström RC

更新日期：2001-07-01 00:00:00

abstract：:Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...

journal_title：Oral oncology

authors： Shiah SG,Chang LC,Tai KY,Lee GH,Wu CW,Shieh YS

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:The hepatocyte growth factor receptor (Met) is frequently overexpressed in Head and Neck Squamous Cell Carcinoma (HNSCC), correlating positively with high-grade tumors and shortened patient survival. As such, Met may represent an important therapeutic target. The purpose of this study was to explore the role...

journal_title：Oral oncology

authors： Tao X,Hill KS,Gaziova I,Sastry SK,Qui S,Szaniszlo P,Fennewald S,Resto VA,Elferink LA

更新日期：2014-02-01 00:00:00

abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

journal_title：Oral oncology

authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

更新日期：2000-09-01 00:00:00

abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

journal_title：Oral oncology

authors： Barlak N,Capik O,Sanli F,Karatas OF

更新日期：2020-08-19 00:00:00

abstract：BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

journal_title：Oral oncology

authors： El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

更新日期：2019-03-01 00:00:00

abstract：:Indole-3-carbinol (I3C), a naturally occurring phytochemical found in cruciferous vegetables, has received much attention due to its translational potential in cancer prevention and therapy. In this study, we investigated the antitumor effects of OSU-A9, a structurally optimized I3C derivative, in a panel of oral squa...

journal_title：Oral oncology

authors： Weng JR,Bai LY,Omar HA,Sargeant AM,Yeh CT,Chen YY,Tsai MH,Chiu CF

更新日期：2010-10-01 00:00:00

abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...

journal_title：Oral oncology

authors： Bozec A,Formento P,Fischel JL,Etienne-Grimaldi MC,Milano G

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To identify predictors of unplanned hospitalization and emergency department (ED) use among head and neck oncology patients. METHODS:Peer reviewed publications were identified through a systematic search of MEDLINE, Embase and Cochrane CENTRAL. Studies describing a cohort of HNC patients that detailed predic...

journal_title：Oral oncology

authors： Noel CW,Forner D,Wu V,Enepekides D,Irish JC,Husain Z,Chan KKW,Hallet J,Coburn N,Eskander A

更新日期：2020-12-01 00:00:00

abstract：:The techniques of lymphatic mapping and sentinel node biopsy are finding increasing utility in the management of the loco-regional lymphatics in many areas of oncology. Our unit is currently investigating their feasibility in relation to the management of the clinically node negative neck in oral squamous cell carcino...

journal_title：Oral oncology

authors： Hyde NC,Prvulovich E,Keshtgar MR

更新日期：2002-12-01 00:00:00

abstract：:Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different ...

journal_title：Oral oncology

authors： Rangiani A,Motahhary P

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:Head and neck cancer patients and their caregivers report high rates of psychological distress. High rates of physical symptom burden and the increased need for family members to provide caregiving during treatment may contribute to this distress. METHODS:This study examined trajectories of patient and care...

journal_title：Oral oncology

authors： Badr H,Gupta V,Sikora A,Posner M

更新日期：2014-10-01 00:00:00

abstract：:Ameloblastoma is the most common odontogenic tumor. It can exhibit a variety of histological patterns, a great infiltrative potential and a high recurrence rate. Mutations in microsatellite sequences are a hallmark of neoplastic transformation but little is known about their role in ameloblastoma development. In this ...

journal_title：Oral oncology

authors： Migaldi M,Sartori G,Rossi G,Cittadini A,Sgambato A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

journal_title：Oral oncology

authors： Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

更新日期：2015-12-01 00:00:00

abstract：:Early detection of oral cancer is crucial in improving survival rate. Identification and detection of oral potentially malignant disorders (OPMD) allow delivery of interventions to reduce the evolution of these disorders to malignancy. A variety of new and emerging diagnostic aids and adjunctive techniques are current...

journal_title：Oral oncology

authors： Awan KH,Morgan PR,Warnakulasuriya S

更新日期：2011-04-01 00:00:00

abstract：:The aims of this study were to assess a cohort of patients with head and neck squamous cell carcinoma (HNSCC) for: (1) the prevalence of synchronous distant metastases (DM) as detected by the initial staging by using (18)F-FDG PET/CT, (2) the prevalence of metachronous DM, and (3) the validity of published risk factor...

journal_title：Oral oncology

authors： Haerle SK,Schmid DT,Ahmad N,Hany TF,Stoeckli SJ

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and charac...

journal_title：Oral oncology

authors： Kujiraoka S,Tsunematsu T,Sato Y,Yoshida M,Ishikawa A,Tohyama R,Tanaka M,Kobayashi Y,Kondo T,Ushio A,Otsuka K,Kurosawa M,Saito M,Yamada A,Arakaki R,Nagai H,Nikai H,Takeuchi K,Nagao T,Miyamoto Y,Ishimaru N,Kudo Y

更新日期：2017-06-01 00:00:00

abstract：:Head and neck malignant tumors are classified according to the TNM staging system. The TNM system is a universally accepted, widely used, staging method. Its goals are to help clinicians and researchers to choose from treatment options, to give patients an estimate of their prognosis and to compare results of treatmen...

journal_title：Oral oncology

authors： van der Schroeff MP,Baatenburg de Jong RJ

更新日期：2009-04-01 00:00:00

abstract：:Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...

journal_title：Oral oncology

authors： Obara S,Yamamoto K,Hosogai N,Yoshimura Y

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...

journal_title：Oral oncology

authors： Yagyuu T,Hatakeyama K,Imada M,Kurihara M,Matsusue Y,Yamamoto K,Obayashi C,Kirita T

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Human papillomavirus (HPV)-positive tumor status is associated with improved prognosis after disease recurrence in oropharyngeal squamous cell carcinoma (OPSCC). In this study the potential role of survival bias in the relationship between HPV tumor status and the timing of recurrence was evaluated, given co...

journal_title：Oral oncology

authors： Guo T,Rettig E,Fakhry C

更新日期：2016-01-01 00:00:00