当前位置： SCI文献检索 > ORAL ONCOLOGY期刊下所有文献 > The value of (18)F-FDG PET/CT for the detection of distant metastases in high-risk patients with head and neck squamous cell carcinoma.

The value of (18)F-FDG PET/CT for the detection of distant metastases in high-risk patients with head and neck squamous cell carcinoma.

Abstract：

:The aims of this study were to assess a cohort of patients with head and neck squamous cell carcinoma (HNSCC) for: (1) the prevalence of synchronous distant metastases (DM) as detected by the initial staging by using (18)F-FDG PET/CT, (2) the prevalence of metachronous DM, and (3) the validity of published risk factors with special emphasis on the maximum standardized uptake value (SUV max) for the prediction of DM. Two hundred and ninety nine patients with advanced HNSCC were included. Following risk factors at the time of diagnosis and during follow-up were analyzed: advanced T/N stage, poor histological differentiation, level IV/Vb lymph nodes, primary site in the larynx/hypopharynx, and SUV max. The prevalence of DM at initial staging and during follow-up was 10% and 11%, respectively. At initial staging, primary site in the larynx/hypopharynx and neck nodes in level IV/Vb, and during follow-up only level IV/Vb nodes achieved statistical significance. The sensitivity for (18)F-FDG PET/CT with regard to the detection of DM was 96.8%, the specificity 95.4%, the positive predictive value (PV) 69.8%, and the negative PV 99.6%. Patients without DM showed a significantly better overall survival (OS) than patients developing DM (p<0.001). There was no significant difference in OS with regard to the time of diagnosis of DM. The prevalence for synchronous and metachronous DM in advanced HNSCC is considerable. (18)F-FDG PET/CT is highly accurate for initial staging and follow-up. DM carries a bad prognosis regardless of the time of diagnosis.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Haerle SK,Schmid DT,Ahmad N,Hany TF,Stoeckli SJ

doi

10.1016/j.oraloncology.2011.05.011

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

653-9

issue

7

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(11)00188-6

journal_volume

47

pub_type

杂志文章

相关文献

ORAL ONCOLOGY文献大全
  • Confocal laser endomicroscopy for non-invasive head and neck cancer imaging: a comprehensive review.

    abstract：:Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2014.05.002

    authors： Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

    更新日期：2014-08-01 00:00:00

  • Expression of vascular endothelial growth factor A, B, C, and D in oral squamous cell carcinoma.

    abstract：:Vascular endothelial growth factor (VEGF) A is known to play an important role in tumor angiogenesis. The additional members of the VEGF family, VEGF B, C and D have been discovered. VEGF C and D show some selectivity toward lymphatic endothelial cells. However, whether VEGF family members play a role in tumor angioge...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(03)00127-1

    authors： Shintani S,Li C,Ishikawa T,Mihara M,Nakashiro K,Hamakawa H

    更新日期：2004-01-01 00:00:00

  • Salivary gland carcinoma in Denmark 1990-2005: outcome and prognostic factors. Results of the Danish Head and Neck Cancer Group (DAHANCA).

    abstract：:To describe outcome and prognostic factors in a national Danish series of patients treated for salivary gland carcinoma. From three Danish nation-wide registries and supplementary patient records, 871 patients diagnosed with primary major or minor salivary gland carcinoma in the period from 1990 to 2005 were identifie...

    journal_title：Oral oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.oraloncology.2011.09.005

    authors： Bjørndal K,Krogdahl A,Therkildsen MH,Overgaard J,Johansen J,Kristensen CA,Homøe P,Sørensen CH,Andersen E,Bundgaard T,Primdahl H,Lambertsen K,Andersen LJ,Godballe C

    更新日期：2012-02-01 00:00:00

  • Late stage diagnosis of oral cancer: components and possible solutions.

    abstract：:Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research fo...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2014.09.005

    authors： Güneri P,Epstein JB

    更新日期：2014-12-01 00:00:00

  • Influence of p53 and bcl-2 on proliferative activity and treatment outcome in head and neck cancer patients.

    abstract：:Knowledge about the influence of biomarkers on cell proliferative activity might explain differences in radiosensitivity between head and neck tumors and might improve patient selection for the most optimal treatment strategy. p53 and bcl-2 protein expression were determined immunohistochemically in 56 head and neck c...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(99)00051-2

    authors： Dijkema IM,Struikmans H,Dullens HF,Kal HB,van der Tweel I,Battermann JJ

    更新日期：2000-01-01 00:00:00

  • Odontogenic carcinosarcoma: A systematic review.

    abstract：:The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMe...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2018.08.017

    authors： Schuch LF,de Arruda JAA,Silva LVO,Abreu LG,Silva TA,Mesquita RA

    更新日期：2018-10-01 00:00:00

  • A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.

    abstract：BACKGROUND:ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS:This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available thro...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104900

    authors： Bonomi M,Bhateja P,Issa M,Klamer B,Pan X,Blakaj A,Karivedu V,Mousa L,Mitchell D,Gamez M,Kang S,Seim NB,Old M,Carrau R,Rocco J,Blakaj D

    更新日期：2020-11-01 00:00:00

  • Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors.

    abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.06.012

    authors： Aoki T,Tsukinoki K,Kurabayashi H,Sasaki M,Yasuda M,Ota Y,Watanabe Y,Kaneko A

    更新日期：2006-01-01 00:00:00

  • Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility.

    abstract：:Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here, we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ extract (BQE) increased the secretion of an 85kDa caseinolytic proteinase, specifically precipitated by an anti-MMP-8 antibody, in the c...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2006.11.018

    authors： Liu SY,Liu YC,Huang WT,Huang GC,Chen TC,Lin MH

    更新日期：2007-11-01 00:00:00

  • Impact of histological Oral Tongue Cancer margins on locoregional recurrence: A multi-centre retrospective analysis.

    abstract：OBJECTIVES:To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS:We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.105004

    authors： Daniell J,Udovicich C,Rowe D,McDowell L,Vital D,Bressel M,Magarey MJR,Iseli TA,Wong T,Lekgabe E,Cavanagh K,Fua T,Rischin D,Wiesenfeld D

    更新日期：2020-12-01 00:00:00

  • Comorbidity and diagnostic delay in cancer of the larynx, tongue and pharynx.

    abstract：:Comorbidity and diagnostic delay are independent prognostic factors in head and neck cancer, most notably in laryngeal cancer. We investigated their inter-relationship and their relative significance in survival of three different head and neck cancers. A population-based retrospective cohort of 221 patients with canc...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2008.10.012

    authors： Teppo H,Alho OP

    更新日期：2009-08-01 00:00:00

  • Intravenous myofibroblastic pseudotumour of the buccal mucosa.

    abstract：:An intravenous pseudotumour at a traumatised site of the buccal mucosa of a 68-year-old woman is described. The lesion was composed of reactive spindle cell proliferation, merging of haphazard bizarre cells and inflammatory elements. Cellular morphology and immunohistochemical profile of proliferating cells reflected ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(97)00080-8

    authors： Ide F,Shimoyama T,Horie N

    更新日期：1998-05-01 00:00:00

  • Patterns of failure after reirradiation with intensity-modulated radiation therapy and the competing risk of out-of-field recurrences.

    abstract：PURPOSE:To describe patterns of failure (POF) after reirradiation (reRT) with intensity modulated radiation therapy (IMRT) for recurrent/second primary squamous cell carcinoma of the head and neck. METHODS:From 08/2004-02/2013, 75 consecutive patients received reRT with IMRT. Gross tumor was generally treated with a 5...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.07.012

    authors： Margalit DN,Rawal B,Catalano PJ,Haddad RI,Goguen LA,Annino DJ,Limaye SA,Lorch JH,Lavigne AW,Schoenfeld JD,Sher DJ,Tishler RB

    更新日期：2016-10-01 00:00:00

  • The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2015.02.092

    authors： Martinez-Useros J,Garcia-Foncillas J

    更新日期：2015-05-01 00:00:00

  • Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism.

    abstract：:Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients with squamous cell carcinomas of the head and neck (SCCHN). However, treatment with taxanes is limited by toxicities, including bone marrow suppression and peripheral neuropathies. We proposed that conjugating taxanes to target...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2011.07.029

    authors： Galer CE,Sano D,Ghosh SC,Hah JH,Auzenne E,Hamir AN,Myers JN,Klostergaard J

    更新日期：2011-11-01 00:00:00

  • Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma.

    abstract：:The presence of distant metastasis after the initial treatment of head and neck squamous cell carcinoma is not considered a common event and is associated with a poor outcome. The objective of this study was to investigate the prevalence and risk factors associated with the diagnosis of distant metastasis in oral and ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.01.012

    authors： Kowalski LP,Carvalho AL,Martins Priante AV,Magrin J

    更新日期：2005-05-01 00:00:00

  • Molecular techniques and genetic alterations in head and neck cancer.

    abstract：:It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...

    journal_title：Oral oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.oraloncology.2008.05.015

    authors： Ha PK,Chang SS,Glazer CA,Califano JA,Sidransky D

    更新日期：2009-04-01 00:00:00

  • Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?

    abstract：OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2016.01.001

    authors： Bergamini C,Locati L,Bossi P,Granata R,Alfieri S,Resteghini C,Imbimbo M,Fallai C,Orlandi E,Tana S,Iacovelli NA,Guzzo M,Ibba T,Colombo S,Bianchi R,Pizzi N,Fontanella W,Licitra L

    更新日期：2016-03-01 00:00:00

  • Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection.

    abstract：:Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, g...

    journal_title：Oral oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.oraloncology.2004.02.007

    authors： Campisi G,Giovannelli L,Ammatuna P,Capra G,Colella G,Di Liberto C,Gandolfo S,Pentenero M,Carrozzo M,Serpico R,D'Angelo M

    更新日期：2004-09-01 00:00:00

  • Clinical benefits from endoscopy screening of esophageal second primary tumor for head and neck cancer patients: Analysis of a hospital-based registry.

    abstract：OBJECTIVES:Esophageal second primary tumors (SPTs) in head and neck cancer (HNC) patients is not uncommon. The impact of image-enhanced endoscopy (IEE) screening for esophageal SPT on the outcome of HNC patients has not been well clarified. METHODS AND METHODS:Patients with malignancies of the head and neck region and...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2019.06.038

    authors： Chung CS,Lo WC,Chen KC,Lin CL,Wen MH,Hsieh CH,Lin SC,Liao LJ

    更新日期：2019-09-01 00:00:00

  • Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma.

    abstract：:Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2004.08.016

    authors： Obara S,Yamamoto K,Hosogai N,Yoshimura Y

    更新日期：2005-03-01 00:00:00

  • Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998.

    abstract：:To identify subgroups of oral cavity and pharynx (OCP) cancers that may be etiologically distinct, we evaluated age-adjusted incidence rates by histologic type, anatomical site, race, and sex using cases diagnosed during 1975-1998 in nine US Surveillance, Epidemiology, and End Results (SEER) program registries. Male/f...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(01)00109-9

    authors： Canto MT,Devesa SS

    更新日期：2002-09-01 00:00:00

  • Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma.

    abstract：:Although the amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet been identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromoso...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2005.04.005

    authors： Tsujigiwa H,Nagatsuka H,Han PP,Gunduz M,Siar CH,Oida S,Nagai N

    更新日期：2005-09-01 00:00:00

  • Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.

    abstract：OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2014.12.004

    authors： Saeed AA,Sims AH,Prime SS,Paterson I,Murray PG,Lopes VR

    更新日期：2015-03-01 00:00:00

  • Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission.

    abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to inve...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2011.07.032

    authors： Cheng YS,Rees T,Jordan L,Oxford L,O'Brien J,Chen HS,Wong D

    更新日期：2011-12-01 00:00:00

  • Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma.

    abstract：:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/s1368-8375(02)00115-x

    authors： Pires FR,Shih IeM,da Cruz Perez DE,de Almeida OP,Kowalski LP

    更新日期：2003-04-01 00:00:00

  • Scapular tip-thoracodorsal artery perforator free flap for total/subtotal glossectomy defects: Case series and conformance study.

    abstract：BACKGROUND:Reconstruction of the tongue and floor of mouth after total/subtotal glossectomy poses a major challenge for reconstructive surgeons. Speech and deglutition after total glossectomy are usually significantly impaired, affecting the quality of life of these patients. Maintaining an adequate volume of the recon...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2020.104660

    authors： Ferrari M,Sahovaler A,Chan HHL,Nicolai P,Irish JC,Gilbert RW

    更新日期：2020-06-01 00:00:00

  • Complementary serum test of antibodies to Epstein-Barr virus nuclear antigen-1 and early antigen: a possible alternative for primary screening of nasopharyngeal carcinoma.

    abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2007.10.003

    authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

    更新日期：2008-08-01 00:00:00

  • MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis.

    abstract：:The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

    journal_title：Oral oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.oraloncology.2015.01.008

    authors： Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

    更新日期：2015-04-01 00:00:00

  • N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer.

    abstract：OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

    journal_title：Oral oncology

    pub_type： 杂志文章

    doi：10.1016/j.oraloncology.2012.08.003

    authors： Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

    更新日期：2013-02-01 00:00:00