Molecular techniques and genetic alterations in head and neck cancer.

abstract：:The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. FHIT is frequently abnormal in solid tumours including those of the upper aerodigestive tract (UAT) and has therefore been proposed as a tumour-suppressor gene. T...

journal_title：Oral oncology

authors： Pateromichelakis S,Lee G,Langdon JD,Partridge M

更新日期：2000-03-01 00:00:00

abstract：:Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high r...

journal_title：Oral oncology

authors： Lindeboom JA,Mathura KR,Ince C

更新日期：2006-07-01 00:00:00

abstract：:The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...

journal_title：Oral oncology

authors： Brouwer J,Senft A,de Bree R,Comans EF,Golding RP,Castelijns JA,Hoekstra OS,Leemans CR

更新日期：2006-03-01 00:00:00

abstract：:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...

journal_title：Oral oncology

authors： Mhawech P,Dulguerov P,Assaly M,Ares C,Allal AS

更新日期：2005-01-01 00:00:00

abstract：:Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different ...

journal_title：Oral oncology

authors： Rangiani A,Motahhary P

更新日期：2009-07-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：:This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a...

journal_title：Oral oncology

authors： Mahajan A,Ahuja A,Sable N,Stambuk HE

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor account for 1-2% of thyroid cancer. In this study, we aim to examine the characteristics and survival of patients with MTC. METHODS:A retrospective cohort study utilizing the National Cancer Data Base, 2004-2014. The study population included adult...

journal_title：Oral oncology

authors： Al-Qurayshi Z,Khadra H,Chang K,Pagedar N,Randolph GW,Kandil E

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Head and neck cancer patients and their caregivers report high rates of psychological distress. High rates of physical symptom burden and the increased need for family members to provide caregiving during treatment may contribute to this distress. METHODS:This study examined trajectories of patient and care...

journal_title：Oral oncology

authors： Badr H,Gupta V,Sikora A,Posner M

更新日期：2014-10-01 00:00:00

abstract：:The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...

journal_title：Oral oncology

authors： Kurihara K,Tajima Y,Kawasaki M,Ueha T

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Surgical management of patients following zoledronic acid therapy is particularly difficult, since the dental extraction is the main cause of BRONJ. METHODS:A case-control study was conducted on 176 patients treated with intravenous (IV) bisphosphonates for oncologic pathologies who also underwent dental ex...

journal_title：Oral oncology

authors： Mozzati M,Arata V,Gallesio G

更新日期：2012-09-01 00:00:00

abstract：:In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard d...

journal_title：Oral oncology

authors： Ramírez-Amador V,Esquivel-Pedraza L,Lozada-Nur F,De la Rosa-García E,Volkow-Fernández P,Súchil-Bernal L,Mohar A

更新日期：2002-07-01 00:00:00

abstract：:We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...

journal_title：Oral oncology

authors： Nguyen NP,Ceizyk M,Vos P,Vinh-Hung V,Davis R,Desai A,Abraham D,Krafft SP,Jang S,Watchman CJ,Ewell L,Hamilton R,Smith-Raymond L

更新日期：2010-04-01 00:00:00

abstract：:This report describes highlights the dramatic responses seen in patients who were given paclitaxel post progression on immunotherapy. There are multiple mechanisms by which synergistic effects of immunotherapy and chemotherapy occur. Further prospective studies on chemotherapy and immunotherapy are eagerly awaited. ...

journal_title：Oral oncology

authors： Sukari A,Nagasaka M,Abdallah N

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Several studies have investigated the relationship between the use of dentures and the duration of denture use and cancer development. Of particular interest is whether ill-fitting dentures increase the likelihood of the development of oral cancer. We conducted a meta-analysis to determine the relationship b...

journal_title：Oral oncology

authors： Manoharan S,Nagaraja V,Eslick GD

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution. PATIENTS AND METHODS:An Institutional Review Board (IRB)-approved...

journal_title：Oral oncology

authors： Gupta P,Migliacci JC,Montero PH,Zanoni DK,Shah JP,Patel SG,Ganly I

更新日期：2018-03-01 00:00:00

abstract：:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

journal_title：Oral oncology

authors： Bernstein JM,Homer JJ,West CM

更新日期：2014-10-01 00:00:00

abstract：:Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

journal_title：Oral oncology

authors： Piattelli A,Rubini C,Fioroni M,Iezzi G

更新日期：2000-09-01 00:00:00

abstract：:Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

journal_title：Oral oncology

authors： Ficarra G,Prignano F,Romagnoli P

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVES:The immune system is crucial in the evolution of head and neck cancer. Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between neoplastic cells and immune cells in the tumor microenvironment. The main aim of this study was to apply univariate/multivariate analysis to investigate the p...

journal_title：Oral oncology

authors： Alessandrini L,Franz L,Ottaviano G,Ghi MG,Lanza C,Blandamura S,Marioni G

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy. MATERIALS AND METHODS:We retrospectively analyzed 88 patients receiving total...

journal_title：Oral oncology

authors： Fujii T,Miyabe J,Yoshii T,Suzuki M,Otozai S,Komukai S,Kishikawa T,Takemoto N,Fukusumi T,Tatsumi M,Hatazawa J,Inohara H

更新日期：2019-06-01 00:00:00

abstract：:To determine the aesthetic and functional outcomes of the most invasive approach to oral cavity/oropharyngeal lesions, the lip-splitting mandibulotomy approach (LSMA), versus the least invasive, the trans-oral approach (TOA). Retrospective paired-cohort study. Thirty-six patients with oral/oropharyngeal cancers treate...

journal_title：Oral oncology

authors： Dziegielewski PT,O'Connell DA,Rieger J,Harris JR,Seikaly H

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...

journal_title：Oral oncology

authors： Pierce Campbell CM,Giuliano AR,Torres BN,O'Keefe MT,Ingles DJ,Anderson RL,Teras LR,Gapstur SM

更新日期：2016-04-01 00:00:00

abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:We evaluated the effects of three-dimensional virtual planning and the use of a plate-embedded surgical guide in mandibular reconstruction with microvascular fibula flaps. MATERIALS AND METHODS:We retrospectively reviewed 35 patients who underwent primary mandibular reconstruction with a free fibula flap. T...

journal_title：Oral oncology

authors： Bao T,He J,Yu C,Zhao W,Lin Y,Wang H,Liu J,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several ...

journal_title：Oral oncology

authors： Schmitt NC,Kang H,Sharma A

更新日期：2017-11-01 00:00:00

abstract：:Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

journal_title：Oral oncology

authors： Zhou C,Liu J,Tang Y,Liang X

更新日期：2012-11-01 00:00:00

abstract：:Specific biomarkers are urgently needed for the detection and progression of oral cancer. The objective of this study was to discover cancer biomarkers from oral epithelium through utilizing high throughput quantitative proteomics approaches. Morphologically malignant, epithelial dysplasia, and adjacent normal epithel...

journal_title：Oral oncology

authors： Xiao H,Langerman A,Zhang Y,Khalid O,Hu S,Cao CX,Lingen MW,Wong DTW

更新日期：2015-11-01 00:00:00

abstract：:The aim of this study was to define the appropriate fractionation interval between photodynamic therapies (PDTs) for enhanced anti-tumour effects on human oral squamous cell carcinoma (HOSCC). Reoxygenation of HOSCC and the proliferative kinetics of the tumour cells following PDT exposure were evaluated in terms of im...

journal_title：Oral oncology

authors： Togashi H,Uehara M,Ikeda H,Inokuchi T

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

journal_title：Oral oncology

authors： Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

更新日期：2015-04-01 00:00:00