Abstract：
:Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to compete with the normal microenvironment to overcome anti-tumorigenic pressures. Then, once tissue homeostasis is lost, the altered microenvironment, like that accompanying inflammation, can itself become a potent tumor promoter. This review will discuss the changes that cancer cells undergo in converting from EMT to CSCs in an inflammation microenvironment, to understand the mechanisms behind invasion and metastasis and provide insights into prevention of metastasis.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Zhou C,Liu J,Tang Y,Liang Xdoi
10.1016/j.oraloncology.2012.06.005subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1068-75issue
11eissn
1368-8375issn
1879-0593pii
S1368-8375(12)00201-1journal_volume
48pub_type
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