Abstract：
:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether it has a prognostic value in patients with head and neck squamous cell carcinoma (HNSCC). Ninety-five cases were assessed for ED-B FN expression using immunohistochemistry. Positive ED-B FN expression was significantly associated with tumor grade (p=0.06) and primary tumor site (p=0.02). The larynx was the tumor site associated with the least ED-B FN expression. In univariate analysis, there was no association with disease-free survival (p=0.48), but the mean time to progression was clearly shorter in tumors with positive ED-B FN expression than in those with negative expression (6 vs. 11 months). Patients having tumors expressing the ED-B FN had a trend to a significant lower overall survival in the multivariate analysis (p=0.06). Our study showed that ED-B FN expression might have a prognostic value in patients with HNSCC.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Mhawech P,Dulguerov P,Assaly M,Ares C,Allal ASdoi
10.1016/j.oraloncology.2004.07.003subject
Has Abstractpub_date
2005-01-01 00:00:00pages
82-8issue
1eissn
1368-8375issn
1879-0593pii
S1368-8375(04)00163-0journal_volume
41pub_type
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