Intralesional vinblastine vs. 3% sodium tetradecyl sulfate for the treatment of oral Kaposi's sarcoma. A double blind, randomized clinical trial.

abstract：OBJECTIVES:Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC...

journal_title：Oral oncology

authors： Shaikh MH,Idris A,Johnson NW,Fallaha S,Clarke DTW,Martin D,Morgan IM,Gabrielli B,McMillan NAJ

更新日期：2018-11-01 00:00:00

abstract：:ICAM-5 (telencephalin) is an intercellular adhesion molecule reported to be expressed only in the somatodendritic membrane of telencephalic neurons. We recently identified high ICAM-5 expression in a cDNA array study of head and neck neoplasms with a propensity for perineural invasion. To determine the association of ...

journal_title：Oral oncology

authors： Maruya SI,Myers JN,Weber RS,Rosenthal DI,Lotan R,El-Naggar AK

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significanc...

journal_title：Oral oncology

authors： Kuk SK,Yoon HJ,Hong SD,Hong SP,Lee JI

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...

journal_title：Oral oncology

authors： Howlett J,Hamilton S,Ye A,Jewett D,Riou-Green B,Prisman E,Thamboo A

更新日期：2021-01-24 00:00:00

abstract：OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...

journal_title：Oral oncology

authors： Amini A,Jasem J,Jones BL,Robin TP,McDermott JD,Bhatia S,Raben D,Jimeno A,Bowles DW,Karam SD

更新日期：2016-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSC...

journal_title：Oral oncology

authors： Lin SC,Liu CJ,Lin JA,Chiang WF,Hung PS,Chang KW

更新日期：2010-03-01 00:00:00

abstract：:p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...

journal_title：Oral oncology

authors： Agarwal S,Mathur M,Shukla NK,Ralhan R

更新日期：1998-09-01 00:00:00

abstract：:Oral cancer models have attempted to demonstrate inhibition of oral carcinogenesis. These models used synthetic carcinogens, lacked a specific mechanism of activity or used non-physiologic doses for carcinogen or inhibitor. To correct these problems the tobacco and environmental carcinogen, dibenzo[a,l]pyrene (DB[a,l]...

journal_title：Oral oncology

authors： Schwartz J,Baker V,Larios E,Desai D,Amin S

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:Diffusion weighted imaging (DWI) is a frequently performed MRI sequence in cancer patients. While previous studies have shown the clinical value of the apparent diffusion coefficient (ADC) for response prediction and response monitoring, less is known about the biological background of ADC. In the tumor micr...

journal_title：Oral oncology

authors： Swartz JE,Driessen JP,van Kempen PMW,de Bree R,Janssen LM,Pameijer FA,Terhaard CHJ,Philippens MEP,Willems S

更新日期：2018-02-01 00:00:00

abstract：:There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

journal_title：Oral oncology

authors： Davies AN,Broadley K,Beighton D

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...

journal_title：Oral oncology

authors： Bergamini C,Locati L,Bossi P,Granata R,Alfieri S,Resteghini C,Imbimbo M,Fallai C,Orlandi E,Tana S,Iacovelli NA,Guzzo M,Ibba T,Colombo S,Bianchi R,Pizzi N,Fontanella W,Licitra L

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:...

journal_title：Oral oncology

authors： Xuelei M,Jingwen H,Wei D,Hongyu Z,Jing Z,Changle S,Lei L

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques. PATIENTS AND METHODS:We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-...

journal_title：Oral oncology

authors： Bedogni A,Bettini G,Bedogni G,Menapace G,Sandi A,Michelon F,Di Carlo R,Franco P,Saia G

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication. METHOD:Systematic ...

journal_title：Oral oncology

authors： Farooq S,Khandavilli S,Dretzke J,Moore D,Nankivell PC,Sharma N,Almeida JR,Winter SC,Simon C,Paleri V,De M,Siddiq S,Holsinger C,Ferris RL,Mehanna H

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. MATERIALS AND METHODS:All patients diagnosed with OSCC in E...

journal_title：Oral oncology

authors： Schneider K,Jakobsen KK,Jensen JS,Wessel I,Christensen A,Specht L,Lelkaitis G,Mirian C,Buchwald CV,Grønhøj C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Intestinal-type adenocarcinoma (ITAC) of the ethmoid mostly affects patients exposed to wood dust and has been traditionally treated with bilateral resection. The aim of the present study was to validate unilateral endoscopic resection with transnasal craniectomy (uERTC) in selected ITACs. MATERIALS AND MET...

journal_title：Oral oncology

authors： Schreiber A,Ferrari M,Mattavelli D,Rampinelli V,Taboni S,Vural A,Bignami M,Castelnuovo P,Nicolai P

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS:A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 ...

journal_title：Oral oncology

authors： Liu SZ,Zandberg DP,Schumaker LM,Papadimitriou JC,Cullen KJ

更新日期：2015-09-01 00:00:00

abstract：:Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...

journal_title：Oral oncology

authors： Obara S,Yamamoto K,Hosogai N,Yoshimura Y

更新日期：2005-03-01 00:00:00

abstract：:The techniques of lymphatic mapping and sentinel node biopsy are finding increasing utility in the management of the loco-regional lymphatics in many areas of oncology. Our unit is currently investigating their feasibility in relation to the management of the clinically node negative neck in oral squamous cell carcino...

journal_title：Oral oncology

authors： Hyde NC,Prvulovich E,Keshtgar MR

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVES:For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into...

journal_title：Oral oncology

authors： Aghbari SMH,Abushouk AI,Attia A,Elmaraezy A,Menshawy A,Ahmed MS,Elsaadany BA,Ahmed EM

更新日期：2017-05-01 00:00:00

abstract：:Incidence of oropharyngeal squamous cell carcinoma (OSCC) increased 3% annually from 1973 to 2001. OSCC's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. Case-control studies on HPV detection in non-smoking/non-drinking (NS/ND) OSCC patients have not previously been performed. The prim...

journal_title：Oral oncology

authors： Andrews E,Seaman WT,Webster-Cyriaque J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...

journal_title：Oral oncology

authors： Fan JH,Wang JB,Qu CX,Zhang YQ,Taylor PR,Abnet CC,Dawsey SM,Qiao YL

更新日期：2014-10-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) plays a significant role in cancer therapy as receptors of bacteria-derived immunotherapeutic agents such as OK-432, a streptococcal immunotherapeutic agent. In addition, recent reports demonstrated that TLRs, including TLR4, are also expressed in cancer cells as well as in immunocompetent ...

journal_title：Oral oncology

authors： Tano T,Okamoto M,Kan S,Nakashiro K,Shimodaira S,Yamashita N,Kawakami Y,Hamakawa H

更新日期：2012-08-01 00:00:00

abstract：:Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

journal_title：Oral oncology

authors： Zhou C,Liu J,Tang Y,Liang X

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS:Detailed, type-specific HPV antibody responses were analyzed by ...

journal_title：Oral oncology

authors： Broglie MA,Jochum W,Michel A,Waterboer T,Foerbs D,Schoenegg R,Stoeckli SJ,Pawlita M,Holzinger D

更新日期：2017-07-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblottin...

journal_title：Oral oncology

authors： Lin YW,Li CF,Chen HY,Yen CY,Lin LC,Huang CC,Huang HY,Wu PC,Chen CH,Chen SC,Tai MH

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral...

journal_title：Oral oncology

authors： Chen PY,Chen HH,Hsiao JR,Yang MW,Hsueh WT,Tasi ST,Lin FC,Wu YH

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass Spectrometry holds promise as a non-invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may significantly improve the early diagnosis of oral cancer. The present study was designed to discriminate between tumour...

journal_title：Oral oncology

authors： Maurer K,Eschrich K,Schellenberger W,Bertolini J,Rupf S,Remmerbach TW

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...

journal_title：Oral oncology

authors： Ganzer H,Touger-Decker R,Byham-Gray L,Murphy BA,Epstein JB

更新日期：2015-07-01 00:00:00

abstract：:Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) exp...

journal_title：Oral oncology

authors： Kohno Y,Patel V,Kim Y,Tsuji T,Chin BR,Sun M,Bruce Donoff R,Kent R,Wong D,Todd R

更新日期：2002-04-01 00:00:00