ERCC1 plays an important role in predicting survival outcomes and treatment response for patients with HNSCC: a meta-analysis.


BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:Potentially eligible studies were retrieved using PubMed, Embase and Medline. Basic clinical characteristics of patients and statistical data with the survival data were collected. Then a meta-analysis model was established to investigate the correlation between over-expression of ERCC1 and survival outcome in HNSCC patients as well as to determine whether the treatment response is dependent on expression stature of ERCC1 or not. RESULTS:17 eligible studies and 1263 patients were yielded in our meta-analysis. The pooled HRs with 95% confidence intervals (CIs) for OS and PFS were 2.14 [1.51, 3.05] and 2.60 [1.98, 3.42], respectively. In terms of subgroup analysis, race was found to be a significant factor divided for these analyses, and the pooled HRs for the Asian subgroup are 2.97 [2.05, 4.32] and 2.75 [1.82, 4.13] respectively. In non-Asian subgroup, Pooled HRs indicate the predict role for PFS 2.42 [1.60, 3.66], but no value for OS (P<0.05). With regard to treatment response, the pooled ORs were 3.04 [1.99, 4.62]. Results from subgroup analysis that divided by race further showed that pooled ORs in Asian group were 3.95 [2.30, 6.78] and 1.93 [0.97, 3.84] in non-Asian group. CONCLUSION:ERCC1 could be a fine prognostic factor of HNSCC and can also prompt the treatment response, which might be proven by further multicenter clinical trials.


Oral Oncol


Oral oncology


Xuelei M,Jingwen H,Wei D,Hongyu Z,Jing Z,Changle S,Lei L




Has Abstract


2015-05-01 00:00:00














  • Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).

    abstract::Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genet...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Freier K,Schwaenen C,Sticht C,Flechtenmacher C,Mühling J,Hofele C,Radlwimmer B,Lichter P,Joos S

    更新日期:2007-01-01 00:00:00

  • Confocal laser endomicroscopy for non-invasive head and neck cancer imaging: a comprehensive review.

    abstract::Histological assessment is an essential tool in the diagnosis and guidance of the treatment of various diseases, in particular cancer, of the head and neck. Recent major advances in optical imaging techniques have made it possible to acquire high-resolution in vivo images at the cellular scale. Confocal endomicroscopy...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Abbaci M,Breuskin I,Casiraghi O,De Leeuw F,Ferchiou M,Temam S,Laplace-Builhé C

    更新日期:2014-08-01 00:00:00

  • EB-D fibronectin expression in squamous cell carcinoma of the head and neck.

    abstract::ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Mhawech P,Dulguerov P,Assaly M,Ares C,Allal AS

    更新日期:2005-01-01 00:00:00

  • (18)FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis.

    abstract::We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Xu GZ,Guan DJ,He ZY

    更新日期:2011-07-01 00:00:00

  • Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment.

    abstract:OBJECTIVES:To characterize the representation of women in clinical trials directing the National Comprehensive Cancer Network (NCCN) guidelines for chemotherapy use in head and neck squamous cell carcinoma (HNSCC), as well as the relationship between gender and chemotherapy administration in the definitive treatment of...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Benchetrit L,Torabi SJ,Tate JP,Mehra S,Osborn HA,Young MR,Burtness B,Judson BL

    更新日期:2019-07-01 00:00:00

  • Efficacy of super-selective neck dissection following chemoradiation for advanced head and neck cancer.

    abstract:BACKGROUND:Hypothesizing that neck-level specific locations of residual lymph node metastases following chemoradiation for head and neck cancer are highly predictable, the efficacy of the more targeted lymphadenectomy procedure called super-selective neck dissection (SSND) was evaluated. METHODS:A retrospective analys...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Robbins KT,Dhiwakar M,Vieira F,Rao K,Malone J

    更新日期:2012-11-01 00:00:00

  • Is there an epidemiological link between human papillomavirus DNA and basaloid squamous cell carcinoma of the pharynx?

    abstract::The epidemiological link between human papillomavirus (HPV) DNA and basaloid squamous cell carcinoma (BSCC) of the pharynx was studied. The expression of p53 protein was evaluated by immunohistochemical analysis. The presence of HPV DNA was evaluated by polymerase chain reaction amplification and "in situ" hybridizati...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cabanillas R,Rodrigo JP,Ferlito A,Rinaldo A,Fresno MF,Aguilar C,Alvarez ME,Suárez C

    更新日期:2007-04-01 00:00:00

  • Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma.

    abstract::The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemist...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kishimoto K,Sasaki A,Yoshihama Y,Mese H,Tsukamoto G,Matsumura T

    更新日期:2003-06-01 00:00:00

  • Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.

    abstract::The present investigation has examined the clinical benefits of tobramycin, polymyxin E and amphotericin therapy in the management of oral mucositis in children undergoing chemotherapy prior to bone marrow transplantation. Tobramycin, polymyxin E, and amphotericin reduced the degree of oral mucositis more than convent...

    journal_title:Oral oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bondi E,Baroni C,Prete A,Gatti M,Carrassi A,Lodi G,Porter SR

    更新日期:1997-09-01 00:00:00

  • The role of basement membrane proteins on the expression of neural cell adhesion molecule (N-CAM) in an adenoid cystic carcinoma cell line.

    abstract::We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: França CM,Jaeger MM,Jaeger RG,Araújo NS

    更新日期:2000-03-01 00:00:00

  • Effect of photodynamic therapy using 5-aminolevulinic acid on 4-nitroquinoline-1-oxide-induced premalignant and malignant lesions of mouse tongue.

    abstract::A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ma G,Ikeda H,Inokuchi T,Sano K

    更新日期:1999-01-01 00:00:00

  • Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study.

    abstract::Radiation-induced xerostomia can result in the rapid onset and progression of dental caries in head and neck cancer patients. Topically applied fluorides have been successfully used to inhibit the formation of dental caries in this population. However, because intensive daily self-application is required, compliance i...

    journal_title:Oral oncology

    pub_type: 杂志文章,随机对照试验


    authors: Chambers MS,Mellberg JR,Keene HJ,Bouwsma OJ,Garden AS,Sipos T,Fleming TJ

    更新日期:2006-10-01 00:00:00

  • Relationship between the expressions of PD-L1 and tumor-infiltrating lymphocytes in oral squamous cell carcinoma.

    abstract::Tumor-infiltrating lymphocytes (TILs) are considered to represent immune reactions of the host to a malignant tumor. Programmed death receptor ligand-1 (PD-L1) is a surface protein that blocks the function of T lymphocytes and is expressed on cancer cells. Tumor-associated fibroblasts (TAFs), which influence tumor gro...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Cho YA,Yoon HJ,Lee JI,Hong SP,Hong SD

    更新日期:2011-12-01 00:00:00

  • Salivary gland hypofunction in patients with advanced cancer.

    abstract::There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Davies AN,Broadley K,Beighton D

    更新日期:2002-10-01 00:00:00

  • Cytokeratin expression in precancerous lesions of the human oral cavity.

    abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Vaidya MM,Sawant SS,Borges AM,Ogale SB,Bhisey AN

    更新日期:1998-07-01 00:00:00

  • Outcomes and prognostic factors in modern era management of major salivary gland cancer.

    abstract:OBJECTIVES:There is a dearth of prospective evidence regarding cancer of the major salivary glands. Outcomes and management of major salivary gland are based largely on retrospective series spanning many decades and changes in surgical, radiation, imaging and systemic therapy strategies and technique. We sought to repo...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Jegadeesh N,Liu Y,Prabhu RS,Magliocca KR,Marcus DM,Higgins KA,Vainshtein JM,Trad Wadsworth J,Beitler JJ

    更新日期:2015-08-01 00:00:00

  • Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research.

    abstract::The zebrafish has become a useful model organism for research on development and diseases. However, there has been no zebrafish model system for studying oral carcinogenesis. In the present study, we first characterized the histology of the upper gastrointestinal tract of zebrafish. We found that zebrafish tongue was ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Hu B,Zhang C,Baawo K,Qin R,Cole GJ,Lee JA,Chen X

    更新日期:2010-01-01 00:00:00

  • Prognostic value of DNA ploidy status in patients with oral leukoplakia.

    abstract::Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Bremmer JF,Brakenhoff RH,Broeckaert MA,Beliën JA,Leemans CR,Bloemena E,van der Waal I,Braakhuis BJ

    更新日期:2011-10-01 00:00:00

  • Submental artery island flap versus free flap reconstruction of lateral facial soft tissue and parotidectomy defects: Comparison of outcomes and patient factors.

    abstract:OBJECTIVES:The submental artery island flap (SIF) has recently been described in temporal bone defects. At our institution we have broadened the application of the SIF and modified the harvest technique for complex lateral facial and skull base defects. Our primary aim is to evaluate the outcomes of patients undergoing...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Patel AV,Thuener JE,Clancy K,Ascha M,Manzoor NF,Zender CA

    更新日期:2018-03-01 00:00:00

  • Functional imaging early during (chemo)radiotherapy for response prediction in head and neck squamous cell carcinoma; a systematic review.

    abstract::This systematic review gives an extensive overview of the current state of functional imaging during (chemo)radiotherapy to predict locoregional control (LRC) and overall survival (OS) for head and neck squamous cell carcinoma. MEDLINE and EMBASE were searched for literature until April 2018 assessing the predictive p...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Martens RM,Noij DP,Ali M,Koopman T,Marcus JT,Vergeer MR,de Vet H,de Jong MC,Leemans CR,Hoekstra OS,de Bree R,de Graaf P,Boellaard R,Castelijns JA

    更新日期:2019-01-01 00:00:00

  • Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base.

    abstract:OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Amini A,Jasem J,Jones BL,Robin TP,McDermott JD,Bhatia S,Raben D,Jimeno A,Bowles DW,Karam SD

    更新日期:2016-05-01 00:00:00

  • Severe late dysphagia and cause of death after concurrent chemoradiation for larynx cancer in patients eligible for RTOG 91-11.

    abstract:PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ward MC,Adelstein DJ,Bhateja P,Nwizu TI,Scharpf J,Houston N,Lamarre ED,Lorenz R,Burkey BB,Greskovich JF,Koyfman SA

    更新日期:2016-06-01 00:00:00

  • Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients receiving concurrent chemoradiation.

    abstract:BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...

    journal_title:Oral oncology

    pub_type: 杂志文章,随机对照试验


    authors: Antunes HS,Schluckebier LF,Herchenhorn D,Small IA,Araújo CM,Viégas CM,Rampini MP,Ferreira EM,Dias FL,Teich V,Teich N,Ferreira CG

    更新日期:2016-01-01 00:00:00

  • 'Doing as little as possible and as much as necessary' - Oncological efficacy of marginal mandibulectomy in resection of oral cavity cancers.

    abstract:BACKGROUND:In carefully selected oral cavity cancers, marginal mandibulectomy is an adequate procedure which achieves good disease control adhering to the principle of "doing as little as possible and as much as necessary". METHODOLOGY:This was a retrospective study done by reviewing the medical records of all patient...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Suresh S,Thomas S,Janardhan D,Patil S,George NA,Varghese BT,Iype EM,Rafi M,George CK

    更新日期:2019-08-01 00:00:00

  • Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience.

    abstract:OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Scher ED,Romesser PB,Chen C,Ho F,Wuu Y,Sherman EJ,Fury MG,Wong RJ,McBride S,Lee NY,Riaz N

    更新日期:2015-07-01 00:00:00

  • Podoplanin expression in oral leukoplakia: tumorigenic role.

    abstract:OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: de Vicente JC,Rodrigo JP,Rodriguez-Santamarta T,Lequerica-Fernández P,Allonca E,García-Pedrero JM

    更新日期:2013-06-01 00:00:00

  • Computed tomography evaluation after induction chemotherapy for T3 laryngeal cancer: Does response correlate with vocal cord mobility?

    abstract:OBJECTIVES:After induction chemotherapy (IC) for laryngeal cancer, Computed Tomography (CT) is used to assess tumor response but lacks rationalized methods for measurement of this response. In T3 laryngeal cancer, remobilization of an initially fixed vocal cord (VC) is a major sign of tumor response. We compared the pe...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Garcia GCTE,Gorphe P,Hartl D,Ammari S,Even C,Tao Y,Balleyguier C,Varoquaux A,Bidault F

    更新日期:2019-03-01 00:00:00

  • Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer.

    abstract::In the last decade, human microbiome research is rapidly growing involving several fields of clinical medicine and population health. Although the microbiome seems to be linked to all sorts of diseases, cancer has the biggest potential to be investigated. Following the publication of the National Institute of Health -...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Orlandi E,Iacovelli NA,Tombolini V,Rancati T,Polimeni A,De Cecco L,Valdagni R,De Felice F

    更新日期:2019-12-01 00:00:00

  • Osteoprotegerin (OPG) binds with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): suppression of TRAIL-induced apoptosis in ameloblastomas.

    abstract::Osteoprotegerin (OPG) is a useful receptor in inhibiting Receptor Activator of NFkappaB Ligand (RANKL) in inducing osteoclastogenesis. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a potent apoptosis-inducing ligand in ameloblastomas. Since OPG has been reported to bind to TRAIL as well, the...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Sandra F,Hendarmin L,Nakamura S

    更新日期:2006-04-01 00:00:00

  • Potential role of autofluorescence imaging in determining biopsy of oral potentially malignant disorders: A large prospective diagnostic study.

    abstract::Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome asse...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Shi L,Li C,Shen X,Zhou Z,Liu W,Tang G

    更新日期:2019-11-01 00:00:00