Abstract：
OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared. RESULTS:The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2% vs. 69.4% (p=0.079), respectively. The 3-year local-regional control (53.5% vs. 76.3%; p=0.020) and disease-free survival rates (47.8% vs. 70.0%; p=0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (≤ 2mm), more advanced T stage (T3-4 vs. T1-2), and conventional RT method were associated with worse prognosis. CONCLUSIONS:The addition of chemotherapy to adjuvant radiotherapy is recommended in patients with above risk factors. Our result underscores that IMRT should be considered to apply to OSCC patients referred for postoperative treatment.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Chen PY,Chen HH,Hsiao JR,Yang MW,Hsueh WT,Tasi ST,Lin FC,Wu YHdoi
10.1016/j.oraloncology.2012.02.010subject
Has Abstractpub_date
2012-08-01 00:00:00pages
747-52issue
8eissn
1368-8375issn
1879-0593pii
S1368-8375(12)00061-9journal_volume
48pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract：OBJECTIVES:We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer cell lines that have remained uncharacterized despite being used as model systems for decades. MATERIALS AND METHODS:We performed exome sequencing on 14 oral cavity UM-SCC cell lines and denote the mutational profile of each line. ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.10.031
更新日期：2018-12-01 00:00:00
abstract：:The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00051-8
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor account for 1-2% of thyroid cancer. In this study, we aim to examine the characteristics and survival of patients with MTC. METHODS:A retrospective cohort study utilizing the National Cancer Data Base, 2004-2014. The study population included adult...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.06.002
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2015.09.001
更新日期：2015-11-01 00:00:00
abstract：:Seventeen oral squamous cell carcinoma (SCC) patients underwent chemotherapy with TS-1 (8 males and 9 females, mean age; 75.1 years, range; 47-102 years). TS-1 permitted five cases of oral chemotherapy on an outpatient basis and 8 cases in elder patients over 80-years of age. Excepting five patients who underwent TS-1...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2004.08.016
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVES:After induction chemotherapy (IC) for laryngeal cancer, Computed Tomography (CT) is used to assess tumor response but lacks rationalized methods for measurement of this response. In T3 laryngeal cancer, remobilization of an initially fixed vocal cord (VC) is a major sign of tumor response. We compared the pe...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.01.009
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.06.013
更新日期：2017-08-01 00:00:00
abstract：:Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment of murine OSCC cell lines and syngeneic mode...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.06.026
更新日期：2019-08-01 00:00:00
abstract：:Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high r...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.10.014
更新日期：2006-07-01 00:00:00
abstract：:We demonstrated the accumulation of CD11b(high)Gr-1(+) cells in a murine model of squamous cell carcinoma (SCC). Inoculation of NR-S1K cells derived from oral SCC induced a rapid and clear accumulation of CD11b(high)Gr-1(+) cells in secondary lymphoid organs as well as in peripheral blood. Phenotypic and morphological...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2006.06.009
更新日期：2007-07-01 00:00:00
abstract：:Systemic chemotherapy is increasingly being used with radiotherapy for the radical treatment of advanced head and neck cancers. Chemotherapy offers modest benefits in the metastatic setting. Platinum containing agents are the most active drugs and form the mainstay of most chemotherapy schedules. In recent years taxan...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2010.03.004
更新日期：2010-06-01 00:00:00
abstract：:Screening populations for the early detection of asymptomatic malignancies and potential malignancies are intuitively attractive strategies to control or reduce the burden of oral cancer on society. Subsequent preventive and/or therapeutic measures must, however, be substantiated by prospective randomized controlled t...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2004.04.009
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:The treatment strategy of early stage oral squamous cell carcinoma's (OSCC) resected with close or involved margins is a returning point of discussion. In this study we reviewed the consequences of re-resection (RR), postoperative radiotherapy (PORT) or watchful waiting (WW). PATIENTS AND METHODS:Two-hundre...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.02.014
更新日期：2014-06-01 00:00:00
abstract：:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2007.10.005
更新日期：2008-06-01 00:00:00
abstract：:Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therap...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.11.014
更新日期：2018-01-01 00:00:00
abstract：:Pemetrexed has been evaluated as a novel chemotherapeutic for head and neck cancer (HNC). In this review, we examined the efficacy and tolerability of pemetrexed in patients with HNC. Relevant English-language literature was identified via PubMed and a review of published abstracts from the American Society of Clinica...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2013.01.007
更新日期：2013-06-01 00:00:00
abstract：:Head and neck cancers during pregnancy are rising in incidence. Clinicians need to be aware of the principles of managing these cases. This paper is a review of the literature of head and neck cancers during pregnancy with a short case series of six non-thyroid pregnancy-associated cancers treated by a head and neck o...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2007.02.003
更新日期：2008-03-01 00:00:00
abstract：:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(02)00115-x
更新日期：2003-04-01 00:00:00
abstract：:Facial Paralysis (FP) profoundly impairs the life of individuals, both functionally and psychosocially. Surgical approaches to treat this condition are myriad, but the ultimate goal is to restore symmetry and movement. Ablative surgery for tumors of the head and neck region are amongst the most common etiologies causi...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.08.013
更新日期：2017-11-01 00:00:00
abstract：:Oral lichen planus (OLP) is a chronic inflammatory disease and although classified by WHO as a premalignant condition, the risk for transformation into squamous cell carcinoma of the head and neck (SCCHN) is a matter of great controversy. The p63 gene encodes six different proteins which are required for development o...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.08.001
更新日期：2008-07-01 00:00:00
abstract：:The techniques of lymphatic mapping and sentinel node biopsy are finding increasing utility in the management of the loco-regional lymphatics in many areas of oncology. Our unit is currently investigating their feasibility in relation to the management of the clinically node negative neck in oral squamous cell carcino...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(02)00051-9
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVES:Intestinal-type adenocarcinoma (ITAC) of the ethmoid mostly affects patients exposed to wood dust and has been traditionally treated with bilateral resection. The aim of the present study was to validate unilateral endoscopic resection with transnasal craniectomy (uERTC) in selected ITACs. MATERIALS AND MET...
journal_title：Oral oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.oraloncology.2018.10.027
更新日期：2018-12-01 00:00:00
abstract：:The identification of the proliferative activity in tumours may be useful to predict the biological behaviour of different lesions. Proliferating cell nuclear antigen (PCNA) has been used for the evaluation of the proliferative ability of many lesions. In this study 22 ameloblastomas (4 follicular, 5 plexiform, 4 acan...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00027-x
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVES:High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS:Detailed, type-specific HPV antibody responses were analyzed by ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.05.010
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVES:In shared decision making it is important to adequately, timely and actively involve patients in treatment decisions. Sharing prognostic information can be of key importance. This study describes whether and how prognostic information on life expectancy is included during communication on diagnosis and treat...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.07.014
更新日期：2018-09-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2015.02.092
更新日期：2015-05-01 00:00:00
abstract：:In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers. We analyzed p53 mutations in 121 fresh primary oral squamous cell carcinomas (SCCs)...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(02)00064-7
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVES:The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significanc...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.01.014
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS:Ret...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.104507
更新日期：2020-03-01 00:00:00
abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.06.012
更新日期：2006-01-01 00:00:00
