Abstract：
:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemical expression of Mel-CAM in 41 parotid MEC was correlated with clinical parameters. Ten cases of oral cavity SCC were included for comparison. Mel-CAM expression was found in 92.7% of the MEC but was not expressed by the SCC. Mel-CAM expression was greater in intermediate/high grade tumors, was weaker in patients that presented local recurrence, regional and distant metastasis, but no correlation between Mel-CAM and clinical stage and survival of the patients was found. Decreased Mel-CAM expression can impair cellular contact properties, facilitating growth, cell spreading and metastasis in MEC. Mel-CAM can also be useful in differentiating high grade MEC from SCC.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Pires FR,Shih IeM,da Cruz Perez DE,de Almeida OP,Kowalski LPdoi
10.1016/s1368-8375(02)00115-xsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
277-81issue
3eissn
1368-8375issn
1879-0593pii
S136883750200115Xjournal_volume
39pub_type
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