Abstract:
:Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the importance of accurate diagnosis, management and prognostic implications.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Kusafuka K,Ferlito A,Lewis JS Jr,Woolgar JA,Rinaldo A,Slootweg PJ,Gnepp DR,Devaney KO,Travis WD,Barnes Ldoi
10.1016/j.oraloncology.2011.09.016subject
Has Abstractpub_date
2012-03-01 00:00:00pages
211-5issue
3eissn
1368-8375issn
1879-0593pii
S1368-8375(11)00841-4journal_volume
48pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract:OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2012.02.010
更新日期:2012-08-01 00:00:00
abstract::Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.06.012
更新日期:2011-09-01 00:00:00
abstract::A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00066-9
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Prior studies suggest that oxaliplatin is unique among platinum chemotherapy drugs in its ability to enhance anti-tumor immunity, but the immune mechanisms of different platinum chemotherapy drugs have not been previously compared in preclinical models of head and neck squamous cell carcinoma (HNSCC). MATER...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.06.016
更新日期:2019-08-01 00:00:00
abstract::Prophylactic internal fixation (PIF), with a bone plate in either the anterior (over the section defect) or posterior (on intact cortex) position, has substantially reduced the incidence of fracture at the donor site of the radial osteocutaneous free flap. This study uses the sheep tibia model to compare the effective...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.02.004
更新日期:2011-04-01 00:00:00
abstract::Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) exp...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(01)00055-0
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:Feeding tubes are placed unnecessarily in a proportion of head and neck cancer (HNC) patients treated with chemoradiotherapy (CRT) when prophylactic tube placement protocols are used. This may have a negative impact on the risk of long-term dysphagia. Reactive tube placement protocols, on the other hand, mig...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.11.031
更新日期:2019-01-01 00:00:00
abstract::It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2008.05.015
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2015.10.013
更新日期:2016-01-01 00:00:00
abstract::The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00032-4
更新日期:2000-09-01 00:00:00
abstract::Lip cancer is the most frequent malignant neoplasm of the oral cavity; however, there is no information available on the incidence of this type of cancer in Mexico. This study provides information about the clinico-pathological features of lip cancer patients admitted at a cancer hospital in Mexico City during an 11-y...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2004.04.013
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach. MATERIAL AND METHODS:A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TOR...
journal_title:Oral oncology
pub_type: 信件
doi:10.1016/j.oraloncology.2017.06.028
更新日期:2017-09-01 00:00:00
abstract::This systematic review analyses and describes the application and diagnostic accuracy of Artificial Intelligence (AI) methods used for detection and grading of potentially malignant (pre-cancerous) and cancerous head and neck lesions using whole slide images (WSI) of human tissue slides. Electronic databases MEDLINE v...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2020.104885
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass Spectrometry holds promise as a non-invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may significantly improve the early diagnosis of oral cancer. The present study was designed to discriminate between tumour...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2012.08.012
更新日期:2013-02-01 00:00:00
abstract::There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(01)00133-6
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2015.04.007
更新日期:2015-07-01 00:00:00
abstract::Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.09.002
更新日期:2012-02-01 00:00:00
abstract::The etiology of oral squamous cell carcinoma has been linked to environmental carcinogens, such as activated aromatic heterocyclic radicals and epoxides. Our previous work on implantable and 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer showed that oral glutamine (GLN) inhibited tumor growth possibly thr...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2008.04.008
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...
journal_title:Oral oncology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.oraloncology.2015.10.022
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.10.010
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:The main aim was to investigate the incidence of patient adherence to nutritional tube feeding recommendations in patients with head and neck cancer and to determine patient barriers to meeting tube feeding prescription. MATERIALS AND METHODS:This was an observational study from a randomised controlled tria...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.07.017
更新日期:2017-09-01 00:00:00
abstract::Keratins have been extensively studied in tissues and cultured keratinocytes but limited information is available on epithelia reconstructed in vitro. The aim of this study was to examine keratin expression in organotypic epithelia with normal (NOK), immortalized (SVpgC2a) and malignant (SqCC/Y1) human buccal cells. O...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00089-0
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Pioglitazone has shown an inhibitory effect on the growth of cell lines derived from human salivary gland and human oral squamous cell carcinoma. However, whether this effect can be applied to patients with type 2 diabetes mellitus who use pioglitazone for glycemic control remains unanswered. METHODS:The re...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2013.10.015
更新日期:2014-02-01 00:00:00
abstract::To examine the influence of smoking on observer based morbidity scores and patient assessed health related quality of life after treatment for head and neck cancer. The results of EORTC C30 and H&N35 questionnaires and DAHANCA morbidity scores were studied according to smoking status in 114 recurrence free head and ne...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2006.02.006
更新日期:2007-02-01 00:00:00
abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(97)00046-8
更新日期:1997-11-01 00:00:00
abstract::Our previous study demonstrated that overexpression of Id-1 (inhibitor of differentiation/DNA binding) was associated with lymphatic metastasis in human oral squamous cell carcinoma (OSCC). In this study, we further unveiled the association of Id-1 with vascular endothelial growth factor-C (VEGF-C) and peritumoral lym...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.10.012
更新日期:2011-01-01 00:00:00
abstract::The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2008.03.006
更新日期:2009-01-01 00:00:00
abstract::Maxillary defects can be resolved by prosthetic obturation, autologous tissue reconstruction, or a combination of both. However, there is still controversy in the selection of the optimal approach. Therefore, the aim of this study was to systematically review evidences comparing the performance of obturators and flaps...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.05.019
更新日期:2018-07-01 00:00:00
abstract::The zebrafish has become a useful model organism for research on development and diseases. However, there has been no zebrafish model system for studying oral carcinogenesis. In the present study, we first characterized the histology of the upper gastrointestinal tract of zebrafish. We found that zebrafish tongue was ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2009.09.008
更新日期:2010-01-01 00:00:00
abstract::This report describes highlights the dramatic responses seen in patients who were given paclitaxel post progression on immunotherapy. There are multiple mechanisms by which synergistic effects of immunotherapy and chemotherapy occur. Further prospective studies on chemotherapy and immunotherapy are eagerly awaited. ...
journal_title:Oral oncology
pub_type: 信件
doi:10.1016/j.oraloncology.2018.03.011
更新日期:2018-05-01 00:00:00