Abstract:
:Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) expressing keratinocytes using the TUNEL assay, as well as PCNA and p12(doc-1) immunostaining, respectively. The percentage of TUNEL positive cells progressively increased from normal to dysplastic epithelium (P<0.0019), but returned to normal keratinocyte levels in the malignant epithelium (P<0.20). However, PCNA positive cells increased progressively through hamster oral malignant progression (P<0.0012). The overall ratio of apoptotic to proliferating keratinocytes remains similar until the transition between dysplastic and malignant epithelium, where the ratio is markedly reduced (P<0.05). p12(doc-1) labeling demonstrated a similar expression pattern (P<0.008). This study demonstrates that apoptosis, proliferation and the expression of p12(doc-1) reflects alterations reported during human oral carcinogenesis and supports the use of the Syrian hamster model for the further examination of these pathways.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Kohno Y,Patel V,Kim Y,Tsuji T,Chin BR,Sun M,Bruce Donoff R,Kent R,Wong D,Todd Rdoi
10.1016/s1368-8375(01)00055-0subject
Has Abstractpub_date
2002-04-01 00:00:00pages
274-80issue
3eissn
1368-8375issn
1879-0593pii
S1368837501000550journal_volume
38pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract:BACKGROUND:Reconstruction of the tongue and floor of mouth after total/subtotal glossectomy poses a major challenge for reconstructive surgeons. Speech and deglutition after total glossectomy are usually significantly impaired, affecting the quality of life of these patients. Maintaining an adequate volume of the recon...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104660
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach. MATERIAL AND METHODS:A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TOR...
journal_title:Oral oncology
pub_type: 信件
doi:10.1016/j.oraloncology.2017.06.028
更新日期:2017-09-01 00:00:00
abstract::This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.104658
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:Current guidelines recommend chest computed tomography (CT) with locoregional CT/magnetic resonance imaging for patients with head and neck squamous cell carcinoma (HNSCC), and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT is suggested for stage III-IV patients. However, whole body scree...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.11.026
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:This study aims to compare the prognoses outcomes of mandibular preservation method (MPM) and the mandibulotomy approach (MLA) in oral and oropharyngeal cancer (OOPC) patients. METHOD:We searched PubMed, Web of Science, EMBASE, Chinese BioMedical Literature Database (CBM), Cochrane Library, and clinicaltrial...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析
doi:10.1016/j.oraloncology.2016.11.004
更新日期:2016-12-01 00:00:00
abstract::We assessed the risk factors associated with surgical site infection (SSI) in 697 patients who underwent major oncological surgery for head-and-neck cancer (HNC). SSIs within 30days were classified as incision, space, or leakage/fistula. Preoperative and operative risk factors for SSIs were assessed by univariate and ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.04.002
更新日期:2011-06-01 00:00:00
abstract::Several reports have indicated that nuclear factor-kappa B (NF-κB) is constitutively activated in a variety of cancer cells including human oral squamous carcinoma cells, and play a key role in their growth and survival. Recent studies report that NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibits proli...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.03.001
更新日期:2011-05-01 00:00:00
abstract::Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome asse...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.08.006
更新日期:2019-11-01 00:00:00
abstract::We performed a meta-analysis to evaluate the role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)FDG-PET/CT) in detecting distant metastases and second primary cancers in patients with head and neck cancer (HNC) at staging. Studies about (18)FDG-PET/CT for detecting distant metastase...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.oraloncology.2011.04.021
更新日期:2011-07-01 00:00:00
abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to inve...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.07.032
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:To analyse the survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT) with the high-total- and fractionated-dose simultaneous modulated accelerated radiation therapy (SMART) boost technique and to identify the effect of concurrent ch...
journal_title:Oral oncology
pub_type: 已发布勘误
doi:10.1016/j.oraloncology.2019.01.005
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2016.01.001
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2015.04.014
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immun...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.10.010
更新日期:2018-12-01 00:00:00
abstract::Costimulatory molecules have complementary effects on T-cell activation and their balance may control the development of oral cancer. The aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.03.025
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVES:Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.09.006
更新日期:2018-11-01 00:00:00
abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2009.03.015
更新日期:2009-10-01 00:00:00
abstract::Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...
journal_title:Oral oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.oraloncology.2011.05.001
更新日期:2011-07-01 00:00:00
abstract::We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s1368-8375(00)00068-3
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVES:The treatment strategy of early stage oral squamous cell carcinoma's (OSCC) resected with close or involved margins is a returning point of discussion. In this study we reviewed the consequences of re-resection (RR), postoperative radiotherapy (PORT) or watchful waiting (WW). PATIENTS AND METHODS:Two-hundre...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2014.02.014
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:The advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients' clinical characteristics and circulating HPV DNA detection in the blood of patients wit...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2015.12.002
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS:Detailed, type-specific HPV antibody responses were analyzed by ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.05.010
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:A systematic review to establish what evidence is available for swallowing outcomes following IMRT for head and neck cancer. METHODS:Online electronic databases were searched to identify papers published in English from January 1998 to December 2009. Papers were independently appraised by two reviewers for met...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.oraloncology.2010.07.012
更新日期:2010-10-01 00:00:00
abstract::Proliferative verrucous leukoplakia (PVL) is a very aggressive form of oral leukoplakia (OL) with high morbidity and mortality rates, hypothesised to be linked to HPV infection. This study aimed to determine the presence of HPV DNA in PVL in comparison with OL, and in relation to social-demographical variables (age, g...
journal_title:Oral oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.oraloncology.2004.02.007
更新日期:2004-09-01 00:00:00
abstract::p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00021-9
更新日期:1998-09-01 00:00:00
abstract::Ameloblastoma is the most common odontogenic tumor. It can exhibit a variety of histological patterns, a great infiltrative potential and a high recurrence rate. Mutations in microsatellite sequences are a hallmark of neoplastic transformation but little is known about their role in ameloblastoma development. In this ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2006.12.004
更新日期:2008-01-01 00:00:00
abstract::Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2015.01.007
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.09.023
更新日期:2019-11-01 00:00:00
abstract::Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcino...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(96)00038-3
更新日期:1997-01-01 00:00:00
abstract::Systemic chemotherapy is increasingly being used with radiotherapy for the radical treatment of advanced head and neck cancers. Chemotherapy offers modest benefits in the metastatic setting. Platinum containing agents are the most active drugs and form the mainstay of most chemotherapy schedules. In recent years taxan...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2010.03.004
更新日期:2010-06-01 00:00:00