Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

Abstract:

:Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamous cell carcinoma (SCC). Sixty patients with oral SCC who were treated by primary surgery and microvascular free flap reconstruction, were included in the study. The relation between preoperative levels of serum CRP, clinicopathological features and patient prognosis was determined. This study showed using bivariate analysis (p=0.003) and multivariate analysis (p<0.001) that a raised preoperative CRP was associated with worse overall survival. Tumour size and stage when combined with CRP levels increases the predictive power of this indicator.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

doi

10.1016/j.oraloncology.2009.03.015

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

912-4

issue

10

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(09)00089-X

journal_volume

45

pub_type

杂志文章
  • Specific p53 mutations predict poor prognosis in oral squamous cell carcinoma.

    abstract::In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers. We analyzed p53 mutations in 121 fresh primary oral squamous cell carcinomas (SCCs)...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(02)00064-7

    authors: Yamazaki Y,Chiba I,Hirai A,Sugiura C,Notani K,Kashiwazaki H,Tei K,Totsuka Y,Fukuda H

    更新日期:2003-02-01 00:00:00

  • Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base.

    abstract:OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.02.011

    authors: Amini A,Jasem J,Jones BL,Robin TP,McDermott JD,Bhatia S,Raben D,Jimeno A,Bowles DW,Karam SD

    更新日期:2016-05-01 00:00:00

  • Risk perception of oral cancer in smokers attending primary care: a randomised controlled trial.

    abstract::To encourage the public to attend and accept oral cancer screening, further understanding is required of the ability of structured information to alter patient knowledge and risk perceptions. Previous work has shown the benefit of written information for those at high risk of oral cancer, especially for tobacco smoker...

    journal_title:Oral oncology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.oraloncology.2004.04.008

    authors: Humphris GM,Freeman R,Clarke HM

    更新日期:2004-10-01 00:00:00

  • A phase I study of cabazitaxel in combination with platinum and 5-fluorouracil (PF) in locally advanced squamous cell carcinoma of head and neck (LA-SCCHN).

    abstract:BACKGROUND:There is a clinical need to improve outcomes for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN), especially in Human Papilloma Virus (HPV) negative and HPV positive subtypes with a significant history of tobacco use. In animal models bearing SCCHN, Cabazitaxel showed a...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.05.008

    authors: Camille N,Rozehnal J,Roy E,Uczkowski D,Olson A,Genden E,Teng M,Bakst R,Gupta V,Posner M,Misiukiewicz K

    更新日期:2017-08-01 00:00:00

  • The role of basement membrane proteins on the expression of neural cell adhesion molecule (N-CAM) in an adenoid cystic carcinoma cell line.

    abstract::We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(99)00087-1

    authors: França CM,Jaeger MM,Jaeger RG,Araújo NS

    更新日期:2000-03-01 00:00:00

  • Genomic DNA copy number alterations from precursor oral lesions to oral squamous cell carcinoma.

    abstract::Oral cancer is a multifactorial disease in which both environmental and genetic factors contribute to the aetiopathogenesis. Oral cancer is the sixth most common cancer worldwide with a higher incidence among Melanesian and South Asian countries. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). T...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2014.02.005

    authors: Salahshourifar I,Vincent-Chong VK,Kallarakkal TG,Zain RB

    更新日期:2014-05-01 00:00:00

  • Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity.

    abstract:OBJECTIVES:We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:From January 2005 to September 2008, medical records of 131 consecutive patients with oral...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.02.010

    authors: Chen PY,Chen HH,Hsiao JR,Yang MW,Hsueh WT,Tasi ST,Lin FC,Wu YH

    更新日期:2012-08-01 00:00:00

  • Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI.

    abstract::Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smok...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.104736

    authors: Kreimer AR,Chaturvedi AK,Alemany L,Anantharaman D,Bray F,Carrington M,Doorbar J,D'Souza G,Fakhry C,Ferris RL,Gillison M,Neil Hayes D,Hildesheim A,Huang SH,Kowalski LP,Lang Kuhs KA,Lewis J Jr,Lowy DR,Mehanna H,Ness A

    更新日期:2020-09-01 00:00:00

  • Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment.

    abstract:BACKGROUND:The 2017 National Comprehensive Cancer Network Clinical Practice Guidelines recommend surgical resection or definitive radiation therapy for early-stage oral cavity malignancies, and surgical resection or multimodality clinical trials for late-stage disease. Few studies have been conducted to identify predic...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.06.013

    authors: Fujiwara RJT,Burtness B,Husain ZA,Judson BL,Bhatia A,Sasaki CT,Yarbrough WG,Mehra S

    更新日期:2017-08-01 00:00:00

  • Evaluation of the immunogenicity of ALDH(high) human head and neck squamous cell carcinoma cancer stem cells in vitro.

    abstract:OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.05.013

    authors: Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

    更新日期:2016-08-01 00:00:00

  • Polymorphism of angiotensin I-converting enzyme gene is related to oral cancer and lymph node metastasis in male betel quid chewers.

    abstract:OBJECTIVES:Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs1799752) varian...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.06.003

    authors: Liu YT,Lin LW,Chen CY,Wang CP,Liu HP,Houng JY,Chung FM,Shieh TY

    更新日期:2012-12-01 00:00:00

  • Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1.

    abstract:OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.08.017

    authors: Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

    更新日期:2015-12-01 00:00:00

  • Gene expression profile in oral squamous cell carcinomas and matching normal oral mucosal tissues from black Africans and white Caucasians: the case of the Sudan vs. Norway.

    abstract::Expression profile of 588 known genes relating to tumour biology, was examined between oral squamous cell carcinomas (OSCCs) and matching normal oral mucosal tissues (NOMTs) obtained from Sudanese (n=11) and Norwegian (n=11) patients. cDNA probes were synthesised from total RNA and hybridised with the Atlas human canc...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(02)00018-0

    authors: Ibrahim SO,Aarsaether N,Holsve MK,Kross KW,Heimdal JH,Aarstad JH,Liavaag PG,Elgindi OA,Johannessen AC,Lillehaug JR,Vasstrand EN

    更新日期:2003-01-01 00:00:00

  • Role of AMP-18 in oral mucositis.

    abstract::Oral mucositis (OM) is a devasting toxicity associated with cytotoxic cancer therapy. Antrum mucosal protein (AMP)-18 and a synthetic peptide surrogate, exhibit cell protective and mitogenic properties in in vitro and in vivo models of gastrointestinal epithelial cell injury. The mucosal barrier-protective effects may...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.06.012

    authors: Chen P,Lingen M,Sonis ST,Walsh-Reitz MM,Toback FG

    更新日期:2011-09-01 00:00:00

  • Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.

    abstract::The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2007.11.008

    authors: Martínez A,Brethauer U,Borlando J,Spencer ML,Rojas IG

    更新日期:2008-09-01 00:00:00

  • Malignant extrapleural solitary fibrous tumor arising in the sublingual gland: A case report and review of literature.

    abstract::Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in...

    journal_title:Oral oncology

    pub_type: 信件,评审

    doi:10.1016/j.oraloncology.2018.12.013

    authors: Iorio B,Ronchi A,Montella M,Cozzolino I,De Luca R,Rusciano M,Tartaro G,Colella G,Franco R

    更新日期:2019-03-01 00:00:00

  • Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery.

    abstract::Specific biomarkers are urgently needed for the detection and progression of oral cancer. The objective of this study was to discover cancer biomarkers from oral epithelium through utilizing high throughput quantitative proteomics approaches. Morphologically malignant, epithelial dysplasia, and adjacent normal epithel...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.08.008

    authors: Xiao H,Langerman A,Zhang Y,Khalid O,Hu S,Cao CX,Lingen MW,Wong DTW

    更新日期:2015-11-01 00:00:00

  • The impact of surgery for oral cancer on quality of life as measured by the Medical Outcomes Short Form 36.

    abstract::Quality of life evaluation is an important measure of outcome following the treatment of head and neck cancer. The aim of this study was to evaluate the quality of life of patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma. 50 consecutive patients with previously untreated oral canc...

    journal_title:Oral oncology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s1368-8375(97)00069-9

    authors: Rogers SN,Humphris G,Lowe D,Brown JS,Vaughan ED

    更新日期:1998-05-01 00:00:00

  • Salivary gland hypofunction in patients with advanced cancer.

    abstract::There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(01)00133-6

    authors: Davies AN,Broadley K,Beighton D

    更新日期:2002-10-01 00:00:00

  • VEGF-C contributes to head and neck squamous cell carcinoma growth and motility.

    abstract::Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.02.006

    authors: Benke EM,Ji Y,Patel V,Wang H,Miyazaki H,Yeudall WA

    更新日期:2010-04-01 00:00:00

  • Socio-economic factors and stage at presentation of head and neck cancer patients in Ottawa, Canada: a logistic regression analysis.

    abstract::To determine if socio-economic status (SES) affects the stage at presentation of head and neck cancer (HNC) patients in Ottawa, Canada. To determine if the method of diagnosis affects the stage at presentation in these patients. We obtained data on SES, method of diagnosis, and stage at presentation for patients prese...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.02.010

    authors: Johnson S,Corsten MJ,McDonald JT,Chun J

    更新日期:2010-05-01 00:00:00

  • Study on chemosensitivity of oral squamous cell carcinomas by histoculture drug response assay.

    abstract::The aim of this study was to evaluate the reliability and utility of a histoculture drug response assay (HDRA) for treatment of squamous cell carcinoma in the oral cavity. Nineteen patients with squamous cell carcinoma of the oral cavity were assessed. Tumor tissue samples were histocultured on Gelfoam sponge gels in ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(03)00082-4

    authors: Ariyoshi Y,Shimahara M,Tanigawa N

    更新日期:2003-10-01 00:00:00

  • Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis.

    abstract::Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.oraloncology.2018.04.023

    authors: Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

    更新日期:2018-07-01 00:00:00

  • Weekly and 3-weekly cisplatin concurrent with intensity-modulated radiotherapy in locally advanced head and neck squamous cell cancer.

    abstract::In loco-regionally advanced head and neck squamous cell cancer (HNSCC), concurrent 3-weekly cisplatin improves overall survival (OS) compared to radiotherapy alone, but is often associated with renal toxicity. The use of radiotherapy with accelerated fractionation schedules has been reported to improve survival but it...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.10.005

    authors: Espeli V,Zucca E,Ghielmini M,Giannini O,Salatino A,Martucci F,Richetti A

    更新日期:2012-03-01 00:00:00

  • Risk of contralateral nodal failure following ipsilateral IMRT for node-positive tonsillar cancer.

    abstract:PURPOSE:To determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma. METHODS:Retrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.10.010

    authors: Gottumukkala S,Pham NL,Sumer B,Myers L,Truelson J,Nedzi L,Khan S,Hughes R,Sher DJ

    更新日期:2017-12-01 00:00:00

  • Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism.

    abstract::Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients with squamous cell carcinomas of the head and neck (SCCHN). However, treatment with taxanes is limited by toxicities, including bone marrow suppression and peripheral neuropathies. We proposed that conjugating taxanes to target...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.07.029

    authors: Galer CE,Sano D,Ghosh SC,Hah JH,Auzenne E,Hamir AN,Myers JN,Klostergaard J

    更新日期:2011-11-01 00:00:00

  • Multiple primary tumours in patients with oral squamous cell carcinoma.

    abstract::A series of patients with oral squamous cell carcinoma (SCC) observed at the "Regina Elena" Cancer Institute was retrospectively reviewed in order to analyse the risk factors for multiple and second primary tumours (SPTs), their impact on survival and effective measures to control this phenomenon. In a survey of 200 i...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(98)00105-5

    authors: Cianfriglia F,Di Gregorio DA,Manieri A

    更新日期:1999-03-01 00:00:00

  • Healthy life expectancy of oral squamous cell carcinoma patients aged 75years and older.

    abstract:OBJECTIVES:Healthy life expectancy, an extension of the concept of life expectancy, is a summary measure of population health that takes into account the mortality and morbidity of a population. The aim of the present study was to retrospectively analyze the self-reliance survival times of oral squamous cell carcinoma ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.11.014

    authors: Yamada SI,Kurita H,Tomioka T,Ohta R,Yoshimura N,Nishimaki F,Koyama Y,Kondo E,Kamata T

    更新日期:2017-01-01 00:00:00

  • Inflammation linking EMT and cancer stem cells.

    abstract::Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to c...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2012.06.005

    authors: Zhou C,Liu J,Tang Y,Liang X

    更新日期:2012-11-01 00:00:00

  • Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens.

    abstract:OBJECTIVES:The introduction of intensity modulated radiation therapy (IMRT) has led to new possibilities in the treatment of head and neck cancer (HNC). Limited information is available on how this more advanced radiation technique affects the oral microflora. In a prospective study we assessed the effects of various a...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.05.005

    authors: Schuurhuis JM,Stokman MA,Witjes MJ,Langendijk JA,van Winkelhoff AJ,Vissink A,Spijkervet FK

    更新日期:2016-07-01 00:00:00