Abstract：
:To examine the influence of smoking on observer based morbidity scores and patient assessed health related quality of life after treatment for head and neck cancer. The results of EORTC C30 and H&N35 questionnaires and DAHANCA morbidity scores were studied according to smoking status in 114 recurrence free head and neck cancer patients. In contrast to observer based toxicity scoring, smoking had a significantly negative influence on 20 of the 33 quality of life scales. Previous smokers had quality of life scores in between never smokers and continuous smokers. Smoking after treatment of head and neck cancer adversely influenced a wide range of quality of life endpoints. Quitters had better quality of life than patients who continued to smoke after treatment, suggesting that smoking cessation may improve quality of life in addition to reducing the risk of new cancer.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Jensen K,Jensen AB,Grau Cdoi
10.1016/j.oraloncology.2006.02.006subject
Has Abstractpub_date
2007-02-01 00:00:00pages
187-92issue
2eissn
1368-8375issn
1879-0593pii
S1368-8375(06)00052-2journal_volume
43pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract：OBJECTIVE:The present study aimed to clarify the role of Moesin in oral squamous cell carcinoma (OSCC) progression, especially in regulation of cell motility. MATERIALS AND METHODS:Immunohistochemistry and western blotting were used to investigate the expression of Moesin, E-cadherin, p120-catenin and MT1-MMP in norma...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2015.07.003
更新日期：2015-10-01 00:00:00
abstract：:Costimulatory molecules have complementary effects on T-cell activation and their balance may control the development of oral cancer. The aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.03.025
更新日期：2010-07-01 00:00:00
abstract：:The submental artery island flap (SIF) is gaining acceptance as a simple and reliable option in selected oral oncologic reconstructions. The present study aims to assess the usefulness of submental artery flap in oral reconstruction with respect to flap reliability, cosmesis, function, donor site morbidity and oncolog...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2008.02.013
更新日期：2008-11-01 00:00:00
abstract：:We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines differing in TP53 sta...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.10.011
更新日期：2011-01-01 00:00:00
abstract：:Because of increased survival rates in childhood cancer, special interest has been focused on the side-effects of the therapy and the quality of life in long-term survivors. Our aim was to investigate craniofacial growth in children who had received different kinds of antineoplastic therapies for solid tumors. A total...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(01)00002-1
更新日期：2001-10-01 00:00:00
abstract：:This review aims at simplifying the relevant imaging anatomy, guiding the optimal imaging method and highlighting the key imaging findings that influence prognosis and management of oral cavity squamous cell carcinoma (OSCC). Early OSCC can be treated with either surgery alone while advanced cancers are treated with a...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104658
更新日期：2020-05-01 00:00:00
abstract：:Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagno...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard d...
journal_title：Oral oncology
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/s1368-8375(01)00100-2
更新日期：2002-07-01 00:00:00
abstract：:Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of this disease. Efforts are ongoing throughout the world to improve early detection and prevention of H...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2011.02.009
更新日期：2011-04-01 00:00:00
abstract：:Tubulopapillary hidradenoma-like tumor of the mandible is extremely rare, with only 3 cases published in the English-language literature. The clinicopathological characteristics and histogenesis of this tumor are unclear. Few pathologists and perhaps fewer clinicians are familiar with this entity, and it is likely und...
journal_title：Oral oncology
pub_type： 信件
doi：10.1016/j.oraloncology.2019.104448
更新日期：2020-01-01 00:00:00
abstract：:The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.07.009
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. MATERIALS AND METHODS:All patients diagnosed with OSCC in E...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.105031
更新日期：2020-12-01 00:00:00
abstract：:Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2018.08.010
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution. PATIENTS AND METHODS:An Institutional Review Board (IRB)-approved...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.01.013
更新日期：2018-03-01 00:00:00
abstract：:The aim was to determine the immediate influence of a validated patient information leaflet (PIL) on oral cancer and knowledge in primary care attenders. Participants were patients (n=800) attending their primary health care provider from 14 general practices (eight dental and six medical) in the north west of England...
journal_title：Oral oncology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1368-8375(00)00069-5
更新日期：2001-01-01 00:00:00
abstract：:In loco-regionally advanced head and neck squamous cell cancer (HNSCC), concurrent 3-weekly cisplatin improves overall survival (OS) compared to radiotherapy alone, but is often associated with renal toxicity. The use of radiotherapy with accelerated fractionation schedules has been reported to improve survival but it...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.10.005
更新日期：2012-03-01 00:00:00
abstract：:Keratins have been extensively studied in tissues and cultured keratinocytes but limited information is available on epithelia reconstructed in vitro. The aim of this study was to examine keratin expression in organotypic epithelia with normal (NOK), immortalized (SVpgC2a) and malignant (SqCC/Y1) human buccal cells. O...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00089-0
更新日期：2001-07-01 00:00:00
abstract：:Ameloblastoma is the most common odontogenic tumor. It can exhibit a variety of histological patterns, a great infiltrative potential and a high recurrence rate. Mutations in microsatellite sequences are a hallmark of neoplastic transformation but little is known about their role in ameloblastoma development. In this ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2006.12.004
更新日期：2008-01-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rou...
journal_title：Oral oncology
pub_type： 信件
doi：10.1016/j.oraloncology.2020.104630
更新日期：2020-07-01 00:00:00
abstract：UNLABELLED:Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective. OBJECTI...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.07.002
更新日期：2016-09-01 00:00:00
abstract：:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2007.10.005
更新日期：2008-06-01 00:00:00
abstract：:Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2015.01.007
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVES:Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass Spectrometry holds promise as a non-invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may significantly improve the early diagnosis of oral cancer. The present study was designed to discriminate between tumour...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.08.012
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.06.035
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.06.007
更新日期：2014-09-01 00:00:00
abstract：:We investigated the knowledge and behaviors of a random sample of 500 primary care physicians (PCPs) regarding oral cancer in Calabria (Italy). 87.6% and 64% indicated tobacco and alcohol use as risk factors, only 31.5% and 2.8% having a prior oral cancer lesion and older age. 60.9% knew that squamous-cell carcinoma i...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2003.10.001
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.03.014
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...
journal_title：Oral oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.oraloncology.2016.12.031
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:examine the cost-effectiveness of routine Calcitonin (Ctn) screening test in the United States. MATERIALS AND METHODS:Markov chain model was developed that compares fine-needle aspiration biopsy (FNAB) with Ctn screening vs. FNAB-only in the evaluation of a thyroid nodule with non-highly suspicious findings...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104878
更新日期：2020-11-01 00:00:00
abstract：:Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.03.015
更新日期：2009-10-01 00:00:00
