Semaphorins in vascular development and head and neck squamous cell carcinoma-induced angiogenesis.

Abstract:

:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that is involved in regulation of motility in many different cell types. This review specifically addresses the effects of the semaphorins on physiological and pathological angiogenesis and will discuss the most recent findings on the role of semaphorins in head and neck squamous cell carcinoma-induced angiogenesis.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Sun Q,Nawabi-Ghasimi F,Basile JR

doi

10.1016/j.oraloncology.2007.10.005

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

523-31

issue

6

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(07)00280-1

journal_volume

44

pub_type

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