Abstract：
:Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating evidence that adaptive radiotherapy can reduce toxicity and improve tumor control, though it is not yet known which patients benefit most. For patients with profound tumor regression, there is also uncertainty about how much to shrink the region receiving high radiation dose. Another form of adaptive radiotherapy uses advanced imaging such as positron emission tomography to visualize changes in tumor biology during treatment. Tumor regions that are thought to be more radioresistant can then be treated to a higher radiation dose, and vice-versa. Studies employing this strategy to boost radiation dose have shown a high rate of late toxicity, specifically the development of persistent mucosal ulcers. Therefore, this sort of adaptive radiotherapy is currently confined to the research setting.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Gensheimer MF,Le QTdoi
10.1016/j.oraloncology.2018.08.010subject
Has Abstractpub_date
2018-11-01 00:00:00pages
19-24eissn
1368-8375issn
1879-0593pii
S1368-8375(18)30302-6journal_volume
86pub_type
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