Abstract：
:Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articlesreporting overall survival, disease-free survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Rivera C,Oliveira AK,Costa RAP,De Rossi T,Paes Leme AFdoi
10.1016/j.oraloncology.2017.07.003subject
Has Abstractpub_date
2017-09-01 00:00:00pages
38-47eissn
1368-8375issn
1879-0593pii
S1368-8375(17)30193-8journal_volume
72pub_type
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