Abstract：
:A better understanding of oral cancer pathogenesis is essential to improving patient prognosis and treatment modalities. Research has shown a significant increase in vascularity during the transition from normal oral mucosa, through differing degrees of dysplasia, to invasive carcinoma. A close association between tumour angiogenesis and tumour progression to late oral squamous cell carcinoma has also been reported. Vascular endothelial growth factor (VEGF) acts to induce endothelial proliferation, migration and specialisation in new and developing vascular beds. VEGF is also a promoter of angiogenesis in many tumour types, and has therefore been subject to numerous studies in oral dysplasia and squamous cell carcinomas. The contribution of VEGF to the development of oral dysplasia and invasive carcinomas is currently disputed due to conflicting results within the literature. More research is required before VEGF technology can be used to improve the diagnosis, prognosis and treatment of sufferers.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Johnstone S,Logan RMdoi
10.1016/j.oraloncology.2005.06.020subject
Has Abstractpub_date
2006-04-01 00:00:00pages
337-42issue
4eissn
1368-8375issn
1879-0593pii
S1368-8375(05)00196-Xjournal_volume
42pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract：:Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...
journal_title：Oral oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.oraloncology.2011.05.001
更新日期：2011-07-01 00:00:00
abstract：:Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00118-3
更新日期：1999-05-01 00:00:00
abstract：:Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high r...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.10.014
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:Head and neck squamous cell carcinomas (HNSCCs) exhibit great biological heterogeneity and relatively poor prognosis. Tobacco and alcohol consumption is involved in the cause of the majority of these cancers, but over the last several years, Human Papilloma Virus (HPV) infection has increased specifically in...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.08.016
更新日期：2016-11-01 00:00:00
abstract：:We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s1368-8375(00)00068-3
更新日期：2001-04-01 00:00:00
abstract：:Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies t...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s0964-1955(96)00064-4
更新日期：1997-05-01 00:00:00
abstract：:Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(97)00014-6
更新日期：1997-09-01 00:00:00
abstract：:Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the im...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2011.09.016
更新日期：2012-03-01 00:00:00
abstract：:Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...
journal_title：Oral oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.oraloncology.2005.10.002
更新日期：2006-05-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) A is known to play an important role in tumor angiogenesis. The additional members of the VEGF family, VEGF B, C and D have been discovered. VEGF C and D show some selectivity toward lymphatic endothelial cells. However, whether VEGF family members play a role in tumor angioge...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(03)00127-1
更新日期：2004-01-01 00:00:00
abstract：:Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.02.006
更新日期：2010-04-01 00:00:00
abstract：:Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas (OSCC). We evaluated the presence of myofibroblasts in OSCC and determined whether their presence is associated with clinicop...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.07.001
更新日期：2008-05-01 00:00:00
abstract：:p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(98)00021-9
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:The programmed death pathway plays a role in persistent human papillomavirus (HPV) infection as well as in resistance to immune elimination during malignant progression. In this study, we examined PD-L1 expression by immunohistochemistry and tumour infiltrating lymphocytes (TIL) in 214 patients with orophary...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.03.012
更新日期：2019-05-01 00:00:00
abstract：:Squamous cell carcinoma of the oral cavity (SCC) accounts for 3% of cancers in the western world and 40% of cancers in India. The overall 5-year survival rate is only 50%. Most of the lesions appear intra-orally on the tongue. Results from a previous study demonstrated a significant increase in T and B-lymphocytes und...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2003.08.008
更新日期：2004-03-01 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rou...
journal_title：Oral oncology
pub_type： 信件
doi：10.1016/j.oraloncology.2020.104630
更新日期：2020-07-01 00:00:00
abstract：:Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory. The (99m)Tc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were indiv...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.01.001
更新日期：2010-03-01 00:00:00
abstract：:Histone deacetylases (HDACs) are enzymes that are involved in the remodeling of chromatin and play a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypoacetylation. In recent years, inhibition of HDACs has emerged as a ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2010.01.009
更新日期：2010-05-01 00:00:00
abstract：:The aims of this study were to assess a cohort of patients with head and neck squamous cell carcinoma (HNSCC) for: (1) the prevalence of synchronous distant metastases (DM) as detected by the initial staging by using (18)F-FDG PET/CT, (2) the prevalence of metachronous DM, and (3) the validity of published risk factor...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.05.011
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVES:Dysphagia is a common and debilitating side effect of chemoradiotherapy. Assessment is difficult; swallowing is multifactorial and studies choose from a range of dysphagia assessments. This study intended to investigate the relationship between swallowing assessments of dysphagia in a cohort of patients and ...
journal_title：Oral oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.oraloncology.2015.10.015
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically a...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.09.014
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2013.02.008
更新日期：2013-06-01 00:00:00
abstract：:In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard d...
journal_title：Oral oncology
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/s1368-8375(01)00100-2
更新日期：2002-07-01 00:00:00
abstract：:Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2020.104950
更新日期：2020-08-19 00:00:00
abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.02.004
更新日期：2016-04-01 00:00:00
abstract：:Early detection of oral cancer is crucial in improving survival rate. Identification and detection of oral potentially malignant disorders (OPMD) allow delivery of interventions to reduce the evolution of these disorders to malignancy. A variety of new and emerging diagnostic aids and adjunctive techniques are current...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.02.001
更新日期：2011-04-01 00:00:00
abstract：:Controversy remains about which patients at intermediate risk of recurrence of oral squamous cell carcinoma would benefit from radiotherapy. A retrospective review of computerised database and medical records for 462 consecutive patients at the Regional Maxillofacial Unit in Liverpool who were treated with primary sur...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2006.09.010
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.02.014
更新日期：2017-04-01 00:00:00
abstract：:We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.01.010
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.02.011
更新日期：2016-05-01 00:00:00
