Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT.

abstract：:In our previous study, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including a human immortalized oral epithelial cell (HIOEC) and a cancerous cell line (HB96). Microarray analysis showed that the gene encoding Yes-associated protein (YAP) was significantly increase...

journal_title：Oral oncology

authors： Zhang L,Ye DX,Pan HY,Wei KJ,Wang LZ,Wang XD,Shen GF,Zhang ZY

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...

journal_title：Oral oncology

authors： Zhang S,Zhou X,Wang B,Zhang K,Liu S,Yue K,Zhang L,Wang X

更新日期：2014-09-01 00:00:00

abstract：:Pemetrexed has been evaluated as a novel chemotherapeutic for head and neck cancer (HNC). In this review, we examined the efficacy and tolerability of pemetrexed in patients with HNC. Relevant English-language literature was identified via PubMed and a review of published abstracts from the American Society of Clinica...

journal_title：Oral oncology

authors： Argiris A,Pennella E,Koustenis A,Hossain AM,Obasaju CK

更新日期：2013-06-01 00:00:00

abstract：:We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...

journal_title：Oral oncology

authors： França CM,Jaeger MM,Jaeger RG,Araújo NS

更新日期：2000-03-01 00:00:00

abstract：:The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...

journal_title：Oral oncology

authors： Hindle I,Downer MC,Moles DR,Speight PM

更新日期：2000-07-01 00:00:00

abstract：:Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...

journal_title：Oral oncology

authors： Favia GF,Di Alberti L,Scarano A,Piattelli A

更新日期：1997-11-01 00:00:00

abstract：:Solitary fibrous tumor is an uncommon neoplasm with unpredictable clinical behavior. Malignant solitary fibrous tumor is a rare morphological variant with more aggressive behavior and higher rates of local recurrences and distant metastasis, exceeding rare in oral cavity; our case occurred in the floor of the mouth in...

journal_title：Oral oncology

authors： Iorio B,Ronchi A,Montella M,Cozzolino I,De Luca R,Rusciano M,Tartaro G,Colella G,Franco R

更新日期：2019-03-01 00:00:00

abstract：:Despite easy access to clinical examination majority of oral cancer patients ironically present with locally advanced disease, which is a heterogeneous group that includes all stage III/IV tumours in absence of distant metastasis. The AJCC TNM classification has included all tumours with depth of invasion >1 cm into l...

journal_title：Oral oncology

authors： Dhar H,Vaish R,D'Cruz AK

更新日期：2020-06-01 00:00:00

abstract：:Screening populations for the early detection of asymptomatic malignancies and potential malignancies are intuitively attractive strategies to control or reduce the burden of oral cancer on society. Subsequent preventive and/or therapeutic measures must, however, be substantiated by prospective randomized controlled t...

journal_title：Oral oncology

authors： Lavelle CL,Scully C

更新日期：2005-01-01 00:00:00

abstract：:The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...

journal_title：Oral oncology

authors： Kurihara K,Tajima Y,Kawasaki M,Ueha T

更新日期：1999-07-01 00:00:00

abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-02-01 00:00:00

abstract：:Oral cancer is a potentially preventable disease due to its association with well-known risk factors and easy detectability. There is a significant deficiency in the awareness of oral cancer and its risk factors among the public. Raising public awareness could effectively contribute to achieving a significant reductio...

journal_title：Oral oncology

authors： Elango KJ,Anandkrishnan N,Suresh A,Iyer SK,Ramaiyer SK,Kuriakose MA

更新日期：2011-07-01 00:00:00

abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...

journal_title：Oral oncology

authors： Chang KP,Hsu CL,Chang YL,Tsang NM,Chen CK,Lee TJ,Tsao KC,Huang CG,Chang YS,Yu JS,Hao SP

更新日期：2008-08-01 00:00:00

abstract：:Mucoepidermoid carcinoma is the most common malignant tumor in salivary glands and high-grade mucoepidermoid carcinoma is often accompanied with poor prognosis. Many recent research works demonstrated that stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4) interaction was critical ...

journal_title：Oral oncology

authors： Wen DS,Zhu XL,Guan SM,Wu YM,Yu LL,Wu JZ

更新日期：2008-06-01 00:00:00

abstract：:We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intratumoral (IT) PD-L1+ immune cells (ICs) or CD8+ infiltrating ICs are of prognostic value. Here we report the prognostic significance of these immune biomarkers in an independent validation c...

journal_title：Oral oncology

authors： Young RJ,Bressel M,Porceddu S,Cernelc J,Savas P,Liu H,Urban D,Thai AA,Cooper C,Fua T,Neeson P,Rischin D,Solomon B

更新日期：2020-02-01 00:00:00

abstract：:We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...

journal_title：Oral oncology

authors： Mori A,Tagawa T,Kamei T,Murata T,Inui M,Ohse S

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma. METHODS:Retrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with ...

journal_title：Oral oncology

authors： Gottumukkala S,Pham NL,Sumer B,Myers L,Truelson J,Nedzi L,Khan S,Hughes R,Sher DJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is elevated in a number of cancers, including head and neck cancers, and that its expression c...

journal_title：Oral oncology

authors： Basheer HA,Pakanavicius E,Cooper PA,Shnyder SD,Martin L,Hunter KD,Vinader V,Afarinkia K

更新日期：2018-05-01 00:00:00

abstract：:The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process an...

journal_title：Oral oncology

authors： Zolkind P,Dunn GP,Lin T,Griffith M,Griffith OL,Uppaluri R

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...

journal_title：Oral oncology

authors： Grønhøj C,Kronberg Jakobsen K,Kjær E,Friborg J,von Buchwald C

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...

journal_title：Oral oncology

authors： Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patient...

journal_title：Oral oncology

authors： Kramer FJ,Böhrnsen F,Moser N,Schliephake H

更新日期：2015-07-01 00:00:00

abstract：:To understand the role of 70 kDa heat shock protein (HSP70) in the pathogenesis of oral cancer, its expression was studied in human normal, premalignant and malignant oral mucosa. Cell surface expression of HSP70 was assessed in oral tissue specimens by flow cytometric analysis using a mouse monoclonal antibody agains...

journal_title：Oral oncology

authors： Kaur J,Das SN,Srivastava A,Ralhan R

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:Feeding tubes are placed unnecessarily in a proportion of head and neck cancer (HNC) patients treated with chemoradiotherapy (CRT) when prophylactic tube placement protocols are used. This may have a negative impact on the risk of long-term dysphagia. Reactive tube placement protocols, on the other hand, mig...

journal_title：Oral oncology

authors： Karsten RT,Stuiver MM,van der Molen L,Navran A,de Boer JP,Hilgers FJM,Klop WMC,Smeele LE

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hypothesizing that neck-level specific locations of residual lymph node metastases following chemoradiation for head and neck cancer are highly predictable, the efficacy of the more targeted lymphadenectomy procedure called super-selective neck dissection (SSND) was evaluated. METHODS:A retrospective analys...

journal_title：Oral oncology

authors： Robbins KT,Dhiwakar M,Vieira F,Rao K,Malone J

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:To characterize specific serious toxicities of reRT with intensity modulated radiation therapy (IMRT) for squamous cell carcinoma of the head and neck (SCCHN) and identify treatment-related predictors of toxicity for patient counseling and decision-making. MATERIALS/METHODS:75 consecutive patients with recu...

journal_title：Oral oncology

authors： Margalit DN,Schoenfeld JD,Rawal B,Haddad RI,Catalano PJ,Goguen LA,Chau NG,Rabinowits G,Lorch JH,Annino DJ,Tishler RB

更新日期：2017-10-01 00:00:00

abstract：:Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to look for molecules responsible for its unique metastatic trait. A transcriptomic microa...

journal_title：Oral oncology

authors： Hu K,Li SL,Gan YH,Wang CY,Yu GY

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Induction chemotherapy (IC) followed by chemoradiation (CRT) for locally advanced squamous cell head and neck cancer (SCCHN) remains controversial in the absence of clear evidence to define its role. As part of a prospective, randomised, multicentre study of CRT for stage III/IV laryngeal/hypopharyngeal canc...

journal_title：Oral oncology

authors： Gujral DM,Piercy D,Morden JP,Emson M,Hall E,Miah AB,Bhide SA,Newbold KL,Harrington KJ,Nutting CM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:To report on the feasibility of total laryngopharyngectomy and free jejunal flap transfer for patient with hypopharyngeal cancer via the transoral robotic surgery (TORS) approach. MATERIAL AND METHODS:A patient with hypopharyngeal cancer involving the post-cricoid region is used for demonstration of the TOR...

journal_title：Oral oncology

authors： Chan JYW,Chan RCL,Chow VLY,Tsang RKY,Wong STS,Wei WI

更新日期：2017-09-01 00:00:00

abstract：:It is well known that cellular DNA alterations can lead to the formation of cancer, and there has been much discovery in the pathways involved in the development of head and neck squamous cell carcinoma (HNSCC). With novel genome-wide molecular assays, our ability to detect these abnormalities has increased. We now ha...

journal_title：Oral oncology

authors： Ha PK,Chang SS,Glazer CA,Califano JA,Sidransky D

更新日期：2009-04-01 00:00:00