Abstract：
:Histone deacetylases (HDACs) are enzymes that are involved in the remodeling of chromatin and play a key role in the epigenetic regulation of gene expression. In addition, the activity of non-histone proteins can be regulated through HDAC-mediated hypoacetylation. In recent years, inhibition of HDACs has emerged as a potential strategy to reverse aberrant epigenetic changes associated with cancer, and several classes of HDAC inhibitors have been found to have potent and specific anti-cancer activities in preclinical studies. Many researchers have highlighted the need to determine specific HDAC isotypes related to different tumor types in order to develop selective drugs for specific isoforms and avoid side effects. We summarize recent advances in the understanding of the molecular events that underlie the epigenetic changes in different tissue carcinomas, focusing on oral squamous carcinoma. The role of epigenetics in oral squamous cancer remains poorly understood, and further descriptive studies of specific HDAC member alterations are required to form the basis for future clinical trials.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Iglesias-Linares A,Yañez-Vico RM,González-Moles MAdoi
10.1016/j.oraloncology.2010.01.009subject
Has Abstractpub_date
2010-05-01 00:00:00pages
323-9issue
5eissn
1368-8375issn
1879-0593pii
S1368-8375(10)00021-7journal_volume
46pub_type
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