Abstract：
:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamous cell carcinoma (HNSCC). A systematic review was conducted of prospective DCE-MRI parameter studies in HNSCC in the English language literature. Exclusion criteria were case reports and retrospective series. Six DCE-MRI marker studies in HNSCC met the inclusion criteria. Four studies contained 21-74 patients and two studies recruited 13 and 14 patients. In studies measuring the transfer coefficient (K(trans)), higher overall K(trans) or lower skewness of K(trans) were predictive of a good outcome following chemoradiation. DCE-MRI parameters have the potential to guide treatment in HNSCC. Progress in the field requires standardisation of methods, data sharing and large multi-centre collaborative validation studies.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Bernstein JM,Homer JJ,West CMdoi
10.1016/j.oraloncology.2014.07.011subject
Has Abstractpub_date
2014-10-01 00:00:00pages
963-70issue
10eissn
1368-8375issn
1879-0593pii
S1368-8375(14)00203-6journal_volume
50pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract：UNLABELLED:Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective. OBJECTI...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.07.002
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Cancer immunoediting represents a relatively novel concept attempting to explain the process of tumor escape from the host immune system response. Here, we attempted to elucidate the role of programmed death ligand 1 (PD-L1), the tumor microenvironment, and tumor escape mechanisms that allow malignant transf...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2017.03.006
更新日期：2017-05-01 00:00:00
abstract：:ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether i...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2004.07.003
更新日期：2005-01-01 00:00:00
abstract：:The aim of this study is to assess the impact of prognostic factors in patients with locoregionally advanced nasopharyngeal cancer (NPC), WHO type II-III, treated with two different radiation therapy (RT) schedules: standard radiation therapy (SRT), and accelerated hyperfractionated radiation therapy (HART), with or w...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(01)00034-3
更新日期：2002-02-01 00:00:00
abstract：:The aim of this study was to determine the survival rate of oral cancer patients treated in a medical center in central Taiwan and to investigate whether socio-demographic factors influence their survival. We retrospectively reviewed 1010 chart records of oral cancer patients. Survival was analyzed by the Kaplan-Meier...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.12.007
更新日期：2006-10-01 00:00:00
abstract：:The effect of meat and fat in laryngeal carcinogenesis was examined in a case-control study carried out in Uruguay in the time period 1998-1999. One-hundred and forty patients with squamous cell laryngeal carcinoma and 420 hospitalized patients, afflicted with conditions not related with tobacco smoking, alcohol drink...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00074-9
更新日期：2001-02-01 00:00:00
abstract：:Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2008.03.003
更新日期：2009-01-01 00:00:00
abstract：:Prophylactic internal fixation (PIF), with a bone plate in either the anterior (over the section defect) or posterior (on intact cortex) position, has substantially reduced the incidence of fracture at the donor site of the radial osteocutaneous free flap. This study uses the sheep tibia model to compare the effective...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.02.004
更新日期：2011-04-01 00:00:00
abstract：:To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.04.014
更新日期：2005-10-01 00:00:00
abstract：:This hospital-based cohort study evaluated the efficacy of three Epstein-Barr virus (EBV) - associated assays for nasopharyngeal carcinoma (NPC) primary screening and monitoring treatment outcome. Five hundred and seventeen consecutive subjects, including 156 NPC patients, 264 healthy volunteers and 97 patients with h...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.10.003
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.06.035
更新日期：2019-09-01 00:00:00
abstract：:Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research fo...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2014.09.005
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Oral leukoplakia is a precancerous disorder that is common among residents in Linxian. However, the associations between oral leukoplakia and upper gastrointestinal cancers have not been reported. We investigated the relationships between oral leukoplakia and upper gastrointestinal cancers in the Linxian Gen...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.07.009
更新日期：2014-10-01 00:00:00
abstract：:Hepatoma-derived growth factor (HDGF) participates in oncogenic progression and represents a prognostic factor in several types of cancer. This study aimed to elucidate the role of HDGF during oral carcinogenesis. HDGF expression and the tumorigenic behaviors in human oral cell lines were investigated by immunoblottin...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.01.014
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.05.013
更新日期：2016-08-01 00:00:00
abstract：:Tumor-infiltrating lymphocytes (TILs) are considered to represent immune reactions of the host to a malignant tumor. Programmed death receptor ligand-1 (PD-L1) is a surface protein that blocks the function of T lymphocytes and is expressed on cancer cells. Tumor-associated fibroblasts (TAFs), which influence tumor gro...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.08.007
更新日期：2011-12-01 00:00:00
abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2009.08.006
更新日期：2009-12-01 00:00:00
abstract：:We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngea...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.01.010
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVES:The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patient...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2015.03.011
更新日期：2015-07-01 00:00:00
abstract：:Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas (OSCC). We evaluated the presence of myofibroblasts in OSCC and determined whether their presence is associated with clinicop...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.07.001
更新日期：2008-05-01 00:00:00
abstract：:Mucoepidermoid carcinoma is the most common malignant tumor in salivary glands and high-grade mucoepidermoid carcinoma is often accompanied with poor prognosis. Many recent research works demonstrated that stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4) interaction was critical ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2007.06.016
更新日期：2008-06-01 00:00:00
abstract：:We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intratumoral (IT) PD-L1+ immune cells (ICs) or CD8+ infiltrating ICs are of prognostic value. Here we report the prognostic significance of these immune biomarkers in an independent validation c...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.104516
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Loss of Von Hippel-Lindau (VHL) gene expression has been implicated in the development of human cancers. However, its function in oral squamous cell carcinoma (OSCC) remains undefined. The aim of this study was to clarify the VHL expression in OSCC and to explore the underlying mechanisms of VHL in modulating...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.06.007
更新日期：2014-09-01 00:00:00
abstract：:Oral cancer is a multifactorial disease in which both environmental and genetic factors contribute to the aetiopathogenesis. Oral cancer is the sixth most common cancer worldwide with a higher incidence among Melanesian and South Asian countries. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). T...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2014.02.005
更新日期：2014-05-01 00:00:00
abstract：:The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopatholog...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.05.005
更新日期：2010-08-01 00:00:00
abstract：:Oral leukoplakia is a potentially malignant disorder that will develop into oral cancer at an estimated rate of 1-2% per year. Aim of the present study is to assess the possible predictive value of DNA ploidy for malignant progression of oral leukoplakia. A cohort of 62 leukoplakia patients was studied and their biops...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.07.025
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.03.024
更新日期：2012-09-01 00:00:00
abstract：:Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagno...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(01)00038-0
更新日期：2002-02-01 00:00:00
abstract：:Conventional surgical approaches for tonsillar carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, transoral lateral oropharyngectomy (TLO) using the robotic surgical system was performed, and the efficacy and feasibility of this procedure was evaluated. TLO was perform...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2009.02.012
更新日期：2009-08-01 00:00:00
