Abstract：
:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA's approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstrative of the therapeutic potential of drugs that selectively interfere with mucositis' pathogenesis. A number of eclectic molecules, all designed to interfere with pathways that lead to injury are in pre-clinical and clinical development.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Sonis STdoi
10.1016/j.oraloncology.2009.08.006subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1015-20issue
12eissn
1368-8375issn
1879-0593pii
S1368-8375(09)00892-6journal_volume
45pub_type
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