Abstract:
BACKGROUND:The incidence of nasopharyngeal carcinoma (NPC) is higher in Chinese than in Caucasian populations. Genetic, viral, and lifestyle factors may explain these ethnic differences in the incidence of NPC. In the present study, we examined the familial aggregation, heritability, and relative risks (RRs) of NPC using a nationwide database in Taiwan. METHODS:A population-based family study was conducted using the Taiwan National Health Insurance Research Database. Participants included all individuals (N=23,422,955) registered with that database in 2013; of these, 17,653 had NPC. Among them, 47.45%, 57.45%, 47.29%, and 1.51% had a parent, child, sibling, and twin, respectively, with NPC. RESULTS:Among the approximately 23 million Taiwan NHI beneficiaries in 2013, the relative risks (RRs) (95% confidence intervals) for NPC were 34.46 (5.12-231.77) for twins of the patients, 9.23 (6.34-13.43) for siblings, 3.80 (2.97-4.86) for parents, 3.74 (2.60-5.37) for offspring, and 1.78 (1.16-2.74) for spouses without genetic similarity. The mean age of onset in first-degree relative-affected NPC patients was 35.5years compared to 39.0years for NPC patients without affected first-degree relatives (p≤0.0001). Using a threshold liability model, the accountability for phenotypic variance of NPC was estimated to be 61.3% for genetic factors (heritability), 13.9% for shared environmental factors, and 24.8% for non-shared environmental factors. The probability of a patient with NPC to be sporadic was 82.8%. CONCLUSION:This population-based analysis suggested a strong familial tendency in the development of NPC. Screening of first-degree relatives of NPC patients is recommended, particularly in endemic regions.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Huang SF,Hsiao JH,Young CK,Chien HT,Kuo CF,See LC,Luo SF,Huang LH,Liao CT,Chang TJdoi
10.1016/j.oraloncology.2017.07.020subject
Has Abstractpub_date
2017-10-01 00:00:00pages
10-15eissn
1368-8375issn
1879-0593pii
S1368-8375(17)30211-7journal_volume
73pub_type
杂志文章相关文献
ORAL ONCOLOGY文献大全abstract::Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2008.05.019
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor account for 1-2% of thyroid cancer. In this study, we aim to examine the characteristics and survival of patients with MTC. METHODS:A retrospective cohort study utilizing the National Cancer Data Base, 2004-2014. The study population included adult...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2018.06.002
更新日期:2018-08-01 00:00:00
abstract:IMPORTANCE:United States military personnel during the Vietnam Era were potentially exposed to Agent Orange, a known carcinogen. The link between Agent Orange and head and neck cancers is largely unknown; laryngeal cancer is currently the only subsite with sufficient evidence of an Agent Orange association. OBJECTIVE:...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.104483
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The objective of this network meta-analysis is to optimize the prophylactic treatment for radiotherapy-induced oral mucositis in patients with head and neck cancer (HNSCC) receiving postoperative or definitive radiotherapy with or without chemotherapy. MATERIALS AND METHODS:We searched electronic databases ...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析
doi:10.1016/j.oraloncology.2017.11.001
更新日期:2017-12-01 00:00:00
abstract::Squamous cell carcinoma of the pharynx and larynx (SCCPL) is a genetically complex disease and is frequently associated with nonrandom chromosomal alterations. Fifty primary SCC of the pharynx (oropharynx, n=11): see and hypopharynx, n=11) and larynx ( n=28) were examined for numerical aberrations of chromosomes 8, 9,...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2003.09.008
更新日期:2004-04-01 00:00:00
abstract::Carboplatin (CBDCA) alone or in combination with irradiation and other chemotherapeutic agents has been used for the treatment of oral squamous carcinoma. However, there are some limitations for such therapy because of inherent or acquired resistance to CBDCA. To gain some insights into the association of CBDCA resist...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(00)00098-1
更新日期:2002-01-01 00:00:00
abstract::The p53 pathway is commonly altered during oral and skin carcinogenesis. The lip is a transition tissue between skin and oral mucosa, which in response to UVB exposure also exhibits alterations in the expression of p53 and p53-related genes that could lead to malignant transformation. To assess if the p53-regulated pr...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2007.11.008
更新日期:2008-09-01 00:00:00
abstract::Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2009.11.010
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the new American Joint Committee on Cancer (AJCC) cancer staging manual (8th edition) in an independent cohort of patients surgically treated for oral squamous cell carcinoma in order to determine whether the upstaging of pT and pN classification was indicative of a worse prognosis. METHODS:A co...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2017.05.020
更新日期:2017-08-01 00:00:00
abstract::Recently, we reported the preliminary results of a prospective study on the possible premalignant character of oral lichen planus (OLP) and oral lichenoid lesions (OLL). Based on these data it was concluded that there was some but no convincing support for the hypothesis that patients with OLL have an increased risk o...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2006.09.006
更新日期:2007-09-01 00:00:00
abstract::Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2017.09.008
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2015.10.013
更新日期:2016-01-01 00:00:00
abstract::The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.07.009
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2013.07.012
更新日期:2013-11-01 00:00:00
abstract::In the last decade, human microbiome research is rapidly growing involving several fields of clinical medicine and population health. Although the microbiome seems to be linked to all sorts of diseases, cancer has the biggest potential to be investigated. Following the publication of the National Institute of Health -...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2019.104453
更新日期:2019-12-01 00:00:00
abstract::Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2014.07.011
更新日期:2014-10-01 00:00:00
abstract::Epithelial cell adhesion molecule (EpCAM) is important for cell proliferation and differentiation but mechanisms regulating their expression are unclear. Because EpCAM may play a role in carcinogenesis, we investigated the clinicopathologic significance of its expression in oral squamous cell carcinoma (OSCC) and the ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2008.03.003
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2016.01.001
更新日期:2016-03-01 00:00:00
abstract::Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagno...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2014.02.007
更新日期:2014-05-01 00:00:00
abstract::To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four ou...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.04.014
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques. PATIENTS AND METHODS:We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2020.105073
更新日期:2021-01-01 00:00:00
abstract::Pemetrexed has been evaluated as a novel chemotherapeutic for head and neck cancer (HNC). In this review, we examined the efficacy and tolerability of pemetrexed in patients with HNC. Relevant English-language literature was identified via PubMed and a review of published abstracts from the American Society of Clinica...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/j.oraloncology.2013.01.007
更新日期:2013-06-01 00:00:00
abstract::Retinoids are the natural and synthetic derivatives of vitamin A. Epidemiological studies indicate that a low intake of vitamin A is associated with an increased risk of squamous cancer. In vitro studies on cancer cells show that exposure to retinoids results in the inhibition of growth, by blocking the cell cycle or ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s1368-8375(01)00118-x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2019.09.023
更新日期:2019-11-01 00:00:00
abstract::Tumor microcirculatory characteristics until now have only been assessed by histological examination of biopsies or invasive imaging technique. The recent introduction of orthogonal polarization spectral (OPS) imaging as a new tool for in vivo visualization of human microcirculation makes it possible to acquire high r...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2005.10.014
更新日期:2006-07-01 00:00:00
abstract::The role of chemotherapy (CHX) in squamous cell carcinoma of the head and neck (SCCHN) has been expanding. Although combination chemotherapy regimens regularly produce significantly high response rates, meta-analyses show little benefit regarding final outcome. One way to improve induction CHX is to improve drug combi...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2011.09.003
更新日期:2012-01-01 00:00:00
abstract::Adenocarcinoma of the minor salivary gland (MSG) is a rare neoplasm. It represents about 2% of all MSG malignant tumours. It is more common in the palate and in females. This tumour occurs in a mean age of sixty and its mean size at presentation is 1.5cm. Microscopically, the neoplasms classified as adenocarcinoma not...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2006.12.015
更新日期:2008-03-01 00:00:00
abstract::The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00124-9
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:...
journal_title:Oral oncology
pub_type: 杂志文章,meta分析
doi:10.1016/j.oraloncology.2015.02.094
更新日期:2015-05-01 00:00:00
abstract::The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carci...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/j.oraloncology.2010.06.004
更新日期:2010-09-01 00:00:00