Abstract：
:The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA). In addition, we performed immunohistochemistry for CD31 and measured microvessel density (MVD), which is an indicator of angiogenesis. Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P<0.01] and MEC [P<0.001]) than in benign SGT (PA) samples. Furthermore, MVD values tended to be higher in cases that exhibited high expression of MK, which indicated a significant correlation between the degree of MK expression and MVD (P<0.001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Ota T,Ota K,Jono H,Fujimori H,Ueda M,Shinriki S,Sueyoshi T,Shinohara M,Ando Ydoi
10.1016/j.oraloncology.2010.06.004subject
Has Abstractpub_date
2010-09-01 00:00:00pages
657-61issue
9eissn
1368-8375issn
1879-0593pii
S1368-8375(10)00187-9journal_volume
46pub_type
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