Abstract：
:In the last decade, human microbiome research is rapidly growing involving several fields of clinical medicine and population health. Although the microbiome seems to be linked to all sorts of diseases, cancer has the biggest potential to be investigated. Following the publication of the National Institute of Health - Human Microbiome Project (NIH-HMP), the link between Head and Neck Cancer (HNC) and microbiome seems to be a fast-moving field in research area. However, robust evidence-based literature is still quite scarce. Nevertheless the relationship between oral microbiome and HNC could have important consequences for prevention and early detection of this type of tumors. The aims of the present review are: (i) to discuss current pre-clinical evidence of a role of oral microbiome in HNC; (ii) to report recent developments in understanding the human microbiome's relationship with HNC oncogenesis; (iii) to explore the issue of treatment response and treatment toxicity; (iv) to describe the role of microbiota as potentially modifiable factor suitable for targeting by therapeutics. Further studies are needed to better establish the causal relationship between oral microbiome and HNC oncogenesis. Future trials should continue to explore oral microbiome in order to build the scientific and clinical rationale of HNC preventative and ameliorate treatment outcome.
journal_name
Oral Oncoljournal_title
Oral oncologyauthors
Orlandi E,Iacovelli NA,Tombolini V,Rancati T,Polimeni A,De Cecco L,Valdagni R,De Felice Fdoi
10.1016/j.oraloncology.2019.104453subject
Has Abstractpub_date
2019-12-01 00:00:00pages
104453eissn
1368-8375issn
1879-0593pii
S1368-8375(19)30364-1journal_volume
99pub_type
杂志文章,评审相关文献
ORAL ONCOLOGY文献大全abstract：:Squamous cell carcinoma of the oral cavity (SCC) accounts for 3% of cancers in the western world and 40% of cancers in India. The overall 5-year survival rate is only 50%. Most of the lesions appear intra-orally on the tongue. Results from a previous study demonstrated a significant increase in T and B-lymphocytes und...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2003.08.008
更新日期：2004-03-01 00:00:00
abstract：:Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2008.12.007
更新日期：2009-07-01 00:00:00
abstract：:The detection of distant metastases and second primary tumours at the time of initial evaluation changes the prognosis and influences the selection of treatment modality in patients with HNSCC. Until recently chest CT was the single most effective test to screen for distant metastases in HNSCC patients. In this observ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.07.009
更新日期：2006-03-01 00:00:00
abstract：:A patient is described who initially presented with pemphigus vulgaris, limited to the oral cavity, and weight loss. Although the various laboratory studies pointed to the diagnosis of paraneoplastic pemphigus (PNP), the underlying neoplasm was not detected until 6 months later, when the patient developed shortness of...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00022-1
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:Squamous cell carcinoma of the tongue (TSCC) has one of the poorest prognoses of head and neck cancers. This study aims to improve early detection of the disease by identifying salivary biomarkers that can identify a spectrum of patients progressing from high-risk to TSCC. We also examine the mortality of ex...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.02.006
更新日期：2011-04-01 00:00:00
abstract：:Systemic chemotherapy is increasingly being used with radiotherapy for the radical treatment of advanced head and neck cancers. Chemotherapy offers modest benefits in the metastatic setting. Platinum containing agents are the most active drugs and form the mainstay of most chemotherapy schedules. In recent years taxan...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2010.03.004
更新日期：2010-06-01 00:00:00
abstract：:A unique case of bilateral mucoepidermoid carcinoma arising in pre-existing bilateral Warthin's tumours of the parotid glands is presented. Reports of carcinomas arising in pre-existing unilateral Warthin's tumours are likewise rare with only 3 cases of concern mucoepidermoid carcinoma. This is the first report of bil...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s0964-1955(97)00018-3
更新日期：1997-07-01 00:00:00
abstract：:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(02)00115-x
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2014.07.010
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To identify functional outcome and orbital complication rate of the preserved orbit and to identify predictors of orbital impairment in periorbital free flap reconstruction. MATERIALS AND METHODS:A retrospective review was conducted on patients undergoing orbit-sparing surgery with periorbital free flap reco...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.09.023
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2015.08.017
更新日期：2015-12-01 00:00:00
abstract：:Epidemiological studies showed that stopping smoking substantially decreases the risk of lung cancer. With reference to laryngeal cancer, at least four cohort studies and 15 case-control studies reported information on smoking cessation. These studies indicated that the risk of laryngeal cancer is considerably reduced...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2006.02.008
更新日期：2006-10-01 00:00:00
abstract：:It has been reported that cyclooxygenase-2 (COX-2) plays roles in cell proliferation, tumor invasion and inhibition of apoptosis. We reported COX-2 expression in salivary adenoma and its involvement in inhibition of apoptosis. COX-2 is known to induce a number of cytokines and growth factors. On the other hand, hepato...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2005.06.012
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:Recent studies have identified podoplanin, a mucin-type transmembrane glycoprotein, as a biomarker for oral cancer risk in patients with oral leukoplakia (OPL). The aim of this study was to investigate the potential association between podoplanin and the risk of malignant transformation of OPL with epithelia...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2013.02.008
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2012.10.001
更新日期：2013-04-01 00:00:00
abstract：:Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients with squamous cell carcinomas of the head and neck (SCCHN). However, treatment with taxanes is limited by toxicities, including bone marrow suppression and peripheral neuropathies. We proposed that conjugating taxanes to target...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2011.07.029
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.01.001
更新日期：2016-03-01 00:00:00
abstract：:The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carci...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2010.06.004
更新日期：2010-09-01 00:00:00
abstract：:The techniques of lymphatic mapping and sentinel node biopsy are finding increasing utility in the management of the loco-regional lymphatics in many areas of oncology. Our unit is currently investigating their feasibility in relation to the management of the clinically node negative neck in oral squamous cell carcino...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(02)00051-9
更新日期：2002-12-01 00:00:00
abstract：:Betel quid (BQ) and matrix metalloproteinase-8 (MMP-8) play roles in oral diseases. Here, we analyzed the regulation of MMP-8 by BQ and its effect on cell migration. We found that BQ extract (BQE) increased the secretion of an 85kDa caseinolytic proteinase, specifically precipitated by an anti-MMP-8 antibody, in the c...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2006.11.018
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Reconstruction of the tongue and floor of mouth after total/subtotal glossectomy poses a major challenge for reconstructive surgeons. Speech and deglutition after total glossectomy are usually significantly impaired, affecting the quality of life of these patients. Maintaining an adequate volume of the recon...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2020.104660
更新日期：2020-06-01 00:00:00
abstract：:Carboplatin (CBDCA) alone or in combination with irradiation and other chemotherapeutic agents has been used for the treatment of oral squamous carcinoma. However, there are some limitations for such therapy because of inherent or acquired resistance to CBDCA. To gain some insights into the association of CBDCA resist...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/s1368-8375(00)00098-1
更新日期：2002-01-01 00:00:00
abstract：:We previously showed in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) that the presence of intratumoral (IT) PD-L1+ immune cells (ICs) or CD8+ infiltrating ICs are of prognostic value. Here we report the prognostic significance of these immune biomarkers in an independent validation c...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2019.104516
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2018.09.006
更新日期：2018-11-01 00:00:00
abstract：:Integrins are a family of heterodimeric, cation-dependent cell membrane adhesion molecules which mediate cell-cell and cell-matrix interactions. They play a fundamental role in the maintenance of tissue integrity and in the regulation of cell proliferation, growth, differentiation and migration. It is not surprising, ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s0964-1955(97)00021-3
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVES:The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significanc...
journal_title：Oral oncology
pub_type： 杂志文章
doi：10.1016/j.oraloncology.2016.01.014
更新日期：2016-04-01 00:00:00
abstract：:Periodontal infection may exacerbate during cancer therapy and may result in oral pain and infection, and systemic infection, which may cause morbidity and can lead to mortality in neutropenic cancer patients. Periodontal disease in head and neck cancer patients treated with radiation therapy may lead to acute and chr...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s1368-8375(01)00025-2
更新日期：2001-12-01 00:00:00
abstract：:Sebaceous adenoma is a tumour only rarely located in the oral cavity. Less than 10 cases have been reported. Sebaceous adenoma represents 0.5-0.7% of all monomorphic adenomas. Sebaceous adenoma is mainly constituted by two types of cells, undifferentiated peripheral basaloid cells and cells showing different degrees o...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/s1368-8375(01)00024-0
更新日期：2002-01-01 00:00:00
abstract：:The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that ...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2007.10.005
更新日期：2008-06-01 00:00:00
abstract：:Facial Paralysis (FP) profoundly impairs the life of individuals, both functionally and psychosocially. Surgical approaches to treat this condition are myriad, but the ultimate goal is to restore symmetry and movement. Ablative surgery for tumors of the head and neck region are amongst the most common etiologies causi...
journal_title：Oral oncology
pub_type： 杂志文章,评审
doi：10.1016/j.oraloncology.2017.08.013
更新日期：2017-11-01 00:00:00
