A systematic review of 1143 parapharyngeal space tumors reported over 20 years.


:Parapharyngeal space tumours are rare and most clinicians will only see a small number during their career. We performed a systematic review of 1143 parapharyngeal space tumors published in the past 20 years to increase cumulative experience. A systematic literature review was performed and data on histological diagnosis, presentation, surgical approach and postoperative complications of cases published between 1989 and 2009 were compiled and reviewed. The systematic review identified a total of 1143 parapharyngeal space tumors presented in 17 studies. A majority (82%) were benign and 18% were malignant. The most common presentation was a cervical mass (50%) or an intraoral mass (47%). Approximately 70 different histologic subtypes of parapharyngeal space tumors were reported in the cumulative series. The most common primary lesion was a pleomorphic adenoma (34%). Ninety-five percent of patients underwent surgery. The most frequent approach and used to excise the lesions was the cervical approach (48%) and the commonest complication was the vagus nerve injury seen in 14% of the cases.


Oral Oncol


Oral oncology


Riffat F,Dwivedi RC,Palme C,Fish B,Jani P




Has Abstract


2014-05-01 00:00:00














  • Treatment and outcomes of nasopharyngeal carcinoma in a unique non-endemic population.

    abstract:OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Howlett J,Hamilton S,Ye A,Jewett D,Riou-Green B,Prisman E,Thamboo A

    更新日期:2021-01-24 00:00:00

  • RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers.

    abstract::Mutations in histone modifying enzymes and histone variants were identified in multiple cancers in The Cancer Genome Atlas (TCGA) studies. However, very little progress and understanding has been made in identifying the contribution of epigenetic factors in head and neck squamous cell carcinoma (HNSCC). Here, we repor...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lin D,Lin B,Bhanot H,Riou R,Abt NB,Rajagopal J,Saladi SV

    更新日期:2020-12-01 00:00:00

  • The roles of microRNAs in the stemness of oral cancer cells.

    abstract::Oral cancer (OC), which is the most common form of head and neck cancers, has one of the lowest (~50%) overall 5-year survival rates. The main reasons for this high mortality rate are diagnosis of OC in advanced stages in most patients and spread to distant organs via lymph node metastasis. Many studies have shown tha...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Barlak N,Capik O,Sanli F,Karatas OF

    更新日期:2020-08-19 00:00:00

  • Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder?

    abstract::Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ficarra G,Prignano F,Romagnoli P

    更新日期:1997-09-01 00:00:00

  • Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma.

    abstract::The recent success of immunotherapies has demonstrated the potency of tumor-specific immune cells in mediating tumor rejection and generating durable tumor immunity. Our understanding of the scientific basis of these responses results from the confluence of a better comprehension of the cancer immunoediting process an...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Zolkind P,Dunn GP,Lin T,Griffith M,Griffith OL,Uppaluri R

    更新日期:2017-08-01 00:00:00

  • Complex midfacial defects: Is the extended Abbé flap the ideal solution to a tough problem?

    abstract:OBJECTIVES:The aim of this study was to investigate the role of the extended Abbé flap in the reconstruction of complex midfacial defects (upper lip, nasal base and medial cheek). We describe our personal experience with this method and present some interesting aspects from the relevant literature. MATERIALS AND METHO...

    journal_title:Oral oncology

    pub_type: 信件,多中心研究


    authors: Mantsopoulos K,Iro H,Constantinidis J

    更新日期:2020-01-01 00:00:00

  • Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: A population-based study.

    abstract:PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: van Monsjou HS,Schaapveld M,Hamming-Vrieze O,de Boer JP,van den Brekel MW,Balm AJ

    更新日期:2016-01-01 00:00:00

  • Role of adjuvant chemotherapy in malignant mucosal melanoma of the head and neck.

    abstract::The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopatholog...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Ahn HJ,Na II,Park YH,Cho SY,Lee BC,Lee GH,Koh JS,Lee YS,Shim YS,Kim YK,Kang HJ,Ryoo BY,Yang SH

    更新日期:2010-08-01 00:00:00

  • Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data.

    abstract:OBJECTIVES:For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Aghbari SMH,Abushouk AI,Attia A,Elmaraezy A,Menshawy A,Ahmed MS,Elsaadany BA,Ahmed EM

    更新日期:2017-05-01 00:00:00

  • Nasopharyngeal cancer WHO type II-III: monoinstitutional retrospective analysis with standard and accelerated hyperfractionated radiation therapy.

    abstract::The aim of this study is to assess the impact of prognostic factors in patients with locoregionally advanced nasopharyngeal cancer (NPC), WHO type II-III, treated with two different radiation therapy (RT) schedules: standard radiation therapy (SRT), and accelerated hyperfractionated radiation therapy (HART), with or w...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Franchin G,Vaccher E,Talamini R,Gobitti C,Minatel E,Politi D,Sartor G,Trovò MG,Barzan L

    更新日期:2002-02-01 00:00:00

  • Salivary gland cancer stem cells.

    abstract::Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are res...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Adams A,Warner K,Nör JE

    更新日期:2013-09-01 00:00:00

  • Functional imaging early during (chemo)radiotherapy for response prediction in head and neck squamous cell carcinoma; a systematic review.

    abstract::This systematic review gives an extensive overview of the current state of functional imaging during (chemo)radiotherapy to predict locoregional control (LRC) and overall survival (OS) for head and neck squamous cell carcinoma. MEDLINE and EMBASE were searched for literature until April 2018 assessing the predictive p...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Martens RM,Noij DP,Ali M,Koopman T,Marcus JT,Vergeer MR,de Vet H,de Jong MC,Leemans CR,Hoekstra OS,de Bree R,de Graaf P,Boellaard R,Castelijns JA

    更新日期:2019-01-01 00:00:00

  • Langerhans cell number is a strong and independent prognostic factor for head and neck squamous cell carcinomas.

    abstract:OBJECTIVES:Head and neck squamous cell carcinomas (HNSCCs) exhibit great biological heterogeneity and relatively poor prognosis. Tobacco and alcohol consumption is involved in the cause of the majority of these cancers, but over the last several years, Human Papilloma Virus (HPV) infection has increased specifically in...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kindt N,Descamps G,Seminerio I,Bellier J,Lechien JR,Pottier C,Larsimont D,Journé F,Delvenne P,Saussez S

    更新日期:2016-11-01 00:00:00

  • Bilateral mucoepidermoid carcinomas arising in bilateral pre-existing Warthin's tumours of the parotid gland.

    abstract::A unique case of bilateral mucoepidermoid carcinoma arising in pre-existing bilateral Warthin's tumours of the parotid glands is presented. Reports of carcinomas arising in pre-existing unilateral Warthin's tumours are likewise rare with only 3 cases of concern mucoepidermoid carcinoma. This is the first report of bil...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Seifert G

    更新日期:1997-07-01 00:00:00

  • GAPD and tubulin are suitable internal controls for qPCR analysis of oral squamous cell carcinoma cell lines.

    abstract::The selection of housekeeping genes is critical for gene expression studies. To address this issue, four candidate housekeeping genes, including several commonly used ones, were investigated in oral squamous cell carcinoma cell lines. A simple quantitative RT-PCR approach was employed by comparing relative expression ...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Campos MS,Rodini CO,Pinto-Júnior DS,Nunes FD

    更新日期:2009-02-01 00:00:00

  • Sentinel lymph node biopsy in clinically N0 T1-T2 staged oral cancer: the Dutch multicenter trial.

    abstract:OBJECTIVES:Results of the Dutch multi-institutional trial on sentinel lymph node (SLN) biopsy in oral cancer. PATIENTS AND METHODS:Patients were consecutively enrolled from 4 institutions, with T1/T2 oral cancer and cN0 neck based on palpation and ultrasound guided fine needle aspiration cytology. Lymphatic mapping co...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究


    authors: Flach GB,Bloemena E,Klop WM,van Es RJ,Schepman KP,Hoekstra OS,Castelijns JA,Leemans CR,de Bree R

    更新日期:2014-10-01 00:00:00

  • Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation.

    abstract::Several lines of evidence demonstrated that the stroma surrounding the tumors plays an important role in the growth and progression of several neoplasms, including oral squamous cell carcinomas (OSCC). We evaluated the presence of myofibroblasts in OSCC and determined whether their presence is associated with clinicop...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Kellermann MG,Sobral LM,da Silva SD,Zecchin KG,Graner E,Lopes MA,Kowalski LP,Coletta RD

    更新日期:2008-05-01 00:00:00

  • Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens.

    abstract:OBJECTIVES:The introduction of intensity modulated radiation therapy (IMRT) has led to new possibilities in the treatment of head and neck cancer (HNC). Limited information is available on how this more advanced radiation technique affects the oral microflora. In a prospective study we assessed the effects of various a...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Schuurhuis JM,Stokman MA,Witjes MJ,Langendijk JA,van Winkelhoff AJ,Vissink A,Spijkervet FK

    更新日期:2016-07-01 00:00:00

  • Tumor necrosis factor α induces myofibroblast differentiation in human tongue cancer and promotes invasiveness and angiogenesis via secretion of stromal cell-derived factor-1.

    abstract:OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

    更新日期:2015-12-01 00:00:00

  • Salvage gemcitabine-vinorelbine chemotherapy in patients with metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy.

    abstract:OBJECTIVES:Platinum-based chemotherapy is the recognized first-line treatment for metastatic nasopharyngeal carcinoma (NPC). However there is no standard second-line treatment. This study was designed to evaluate the efficacy and safety of a gemcitabine and vinorelbine combination (GV) in patients with metastatic NPC p...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Chen C,Wang FH,Wang ZQ,An X,Luo HY,Zhang L,Chen YC,Xu RH,Li YH

    更新日期:2012-11-01 00:00:00

  • Maté consumption association with upper aerodigestive tract cancers: A systematic review and meta-analysis.

    abstract::Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析


    authors: Mello FW,Scotti FM,Melo G,Warnakulasuriya S,Guerra ENS,Rivero ERC

    更新日期:2018-07-01 00:00:00

  • Feasibility of transoral lateral oropharyngectomy using a robotic surgical system for tonsillar cancer.

    abstract::Conventional surgical approaches for tonsillar carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, transoral lateral oropharyngectomy (TLO) using the robotic surgical system was performed, and the efficacy and feasibility of this procedure was evaluated. TLO was perform...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Park YM,Lee JG,Lee WS,Choi EC,Chung SM,Kim SH

    更新日期:2009-08-01 00:00:00

  • DNA damage and repair scenario in ameloblastoma.

    abstract::Ameloblastoma is a rare human disease of benign neoplasm odontogenic tumor with a lower prevalence but higher recurrence rate. Etiology of ameloblastoma is not fully understood thus lacks implementation of curative treatments. One of the proposed models of evolution of ameloblastoma is related to alteration in DNA dam...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Toprani SM

    更新日期:2020-09-01 00:00:00

  • The impact of an educational video about radiotherapy and its toxicities in head and neck cancer patients. Evaluation of patients' understanding, anxiety, depression, and quality of life.

    abstract:OBJECTIVES:Head and neck radiotherapy can cause several toxicities, and its management has important treatment implications. Proper information about treatment is crucial to assist patients by preparing them and enhancing their ability to manage their illness. Thus, this study aimed to verify the impact of an education...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Fernandes DT,Prado-Ribeiro AC,Markman RL,Morais K,Moutinho K,Tonaki JO,Brandão TB,Rivera C,Santos-Silva AR,Lopes MA

    更新日期:2020-07-01 00:00:00

  • Submental artery island flap versus free flap reconstruction of lateral facial soft tissue and parotidectomy defects: Comparison of outcomes and patient factors.

    abstract:OBJECTIVES:The submental artery island flap (SIF) has recently been described in temporal bone defects. At our institution we have broadened the application of the SIF and modified the harvest technique for complex lateral facial and skull base defects. Our primary aim is to evaluate the outcomes of patients undergoing...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Patel AV,Thuener JE,Clancy K,Ascha M,Manzoor NF,Zender CA

    更新日期:2018-03-01 00:00:00

  • Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审


    authors: Mercadante V,Al Hamad A,Lodi G,Porter S,Fedele S

    更新日期:2017-03-01 00:00:00

  • Topical agents for oral cancer chemoprevention: A systematic review of the literature.

    abstract:OBJECTIVES/HYPOTHESIS:We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS:A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library....

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Chau L,Jabara JT,Lai W,Svider PF,Warner BM,Lin HS,Raza SN,Fribley AM

    更新日期:2017-04-01 00:00:00

  • Cytokeratin expression in precancerous lesions of the human oral cavity.

    abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Vaidya MM,Sawant SS,Borges AM,Ogale SB,Bhisey AN

    更新日期:1998-07-01 00:00:00

  • Adaptive radiotherapy for head and neck cancer: Are we ready to put it into routine clinical practice?

    abstract::Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审


    authors: Gensheimer MF,Le QT

    更新日期:2018-11-01 00:00:00

  • Comparison of different lymph node staging systems in patients with positive lymph nodes in oral squamous cell carcinoma.

    abstract:OBJECTIVES:The evaluation of neck lymph node metastasis is critical for predicting survival after head and neck cancer treatment. However, traditional pathological N staging does not completely correlate with survival; the total number of lymph nodes resected during surgery affects staging, and a minimal number of node...

    journal_title:Oral oncology

    pub_type: 杂志文章


    authors: Lin NC,Su IH,Hsu JT,Chang YJ,Tsai KY

    更新日期:2021-01-16 00:00:00