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CD40 function in squamous cell cancer of the head and neck.

Abstract：

:CD40 is expressed on basal keratinocytes and Squamous Cell Cancer of the Head and Neck (SCCHN) tumor cells in vivo and in vitro. CD40 ligation reduces proliferation of SCCHN cell lines and enhances EGFr mediated inhibition of proliferation. We investigated the mechanisms of CD40 function and EGFr cross-communication in SCCHN cell lines. CD40 ligation inhibited spontaneous and Fas-induced apoptosis. CD40 ligation specifically increased the secretion of IL-8, VEGF and PGE(2) but not IL-6, IL-10, FasL, GM-CSF, or TGFalpha. Co-ligation with EGFr further increased IL-8, VEGF and PGE(2) secretion. CD40 ligation also induced delayed activation and tyrosine phosphorylation of EGFr. CD40 induces secretion of specific proinflammatory and proangiogenic cytokines, inhibits spontaneous and Fas-induced apoptosis and increases EGFr phosphorylation. CD40 signaling may enhance the survival of SCCHN and tumor stroma.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Cao W,Cavacini LA,Tillman KC,Posner MR

doi

10.1016/j.oraloncology.2004.11.005

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

462-9

issue

5

eissn

1368-8375

issn

1879-0593

pii

S1368-8375(04)00263-5

journal_volume

41

pub_type

杂志文章

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