Nasopharyngeal cancer WHO type II-III: monoinstitutional retrospective analysis with standard and accelerated hyperfractionated radiation therapy.

Abstract:

:The aim of this study is to assess the impact of prognostic factors in patients with locoregionally advanced nasopharyngeal cancer (NPC), WHO type II-III, treated with two different radiation therapy (RT) schedules: standard radiation therapy (SRT), and accelerated hyperfractionated radiation therapy (HART), with or without sequential chemotherapy. Between January 1986 and December 1999, 78 consecutive NPC patients were treated either with SRT (until August 1993) or with HART (from September 1993). Of the 78 patients, 60 were males and 18 females, the median age was 56 years (range 14-83). Nine patients had a non-keratinizing carcinoma (WHO type II) and 69 an undifferentiated carcinoma (WHO type III). Five-year overall survival rate (OS) was 62%. Two months after RT, 73 patients were in complete remission. Disease-free survival (DFS) rates at 5 years were: 85% for the HART and 59% for the SRT group, respectively. A multivariate analysis, age (hazard ratio, HR=4.17 for > or = 60 vs. <50 years) and N-stage (HR=3.56 for N3a-N3b vs. N0-N1) were significant for survival, whereas N-stage (HR=8.23 for N3a-N3b vs. N0-N1) and RT schedule (HR=0.30 for HART vs. SRT) were significant for DFS. In our experience, HART achieved higher DFS rates than SRT; however, HART did not favourably affect OS. Toxicity was comparable in the two RT schedules.

journal_name

Oral Oncol

journal_title

Oral oncology

authors

Franchin G,Vaccher E,Talamini R,Gobitti C,Minatel E,Politi D,Sartor G,Trovò MG,Barzan L

doi

10.1016/s1368-8375(01)00034-3

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

137-44

issue

2

eissn

1368-8375

issn

1879-0593

pii

S1368837501000343

journal_volume

38

pub_type

杂志文章
  • Impact of p16-overexpression on overall and progression-free survival outcomes in oral cavity squamous cell carcinomas: A semi-national, population-based study.

    abstract:OBJECTIVES:Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined. MATERIALS AND METHODS:All patients diagnosed with OSCC in E...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2020.105031

    authors: Schneider K,Jakobsen KK,Jensen JS,Wessel I,Christensen A,Specht L,Lelkaitis G,Mirian C,Buchwald CV,Grønhøj C

    更新日期:2020-12-01 00:00:00

  • Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer.

    abstract:OBJECTIVES:This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS:Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral pre...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2016.09.007

    authors: Cheng SJ,Chang CF,Lee JJ,Chen HM,Wang HJ,Liou YL,Yen C,Chiang CP

    更新日期:2016-11-01 00:00:00

  • Histopathological grading of adenoid cystic carcinoma of the head and neck: analysis of currently used grading systems and proposal for a simplified grading scheme.

    abstract:BACKGROUND:Histopathological grading of adenoid cystic carcinoma (ACC) is a controversial issue. It is generally agreed that solid type ACC has a relatively poor prognosis. However, the amount of solid regions within this often mixed type tumor that predicts a poor prognosis is not firmly established. Some authors stip...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2014.10.007

    authors: van Weert S,van der Waal I,Witte BI,Leemans CR,Bloemena E

    更新日期:2015-01-01 00:00:00

  • Determination of antibodies directed at EBV proteins expressed in both latent and lytic cycles in nasopharyngeal carcinoma.

    abstract:OBJECTIVES:Serologic analyses for anti-EBV antibodies used alone usually have low sensitivity for the diagnosis of nasopharyngeal carcinoma (NPC). We assumed that a combined determination of antibodies directed at EBV proteins expressed in both lytic and latent cycles could increase the sensitivity. MATERIALS AND METH...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.10.001

    authors: Ai P,Wang T,Zhang H,Wang Y,Song C,Zhang L,Li Z,Hu H

    更新日期:2013-04-01 00:00:00

  • The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma. Is there really evidence for a change?

    abstract:BACKGROUND:Several recent studies have shown that incidence of oropharyngeal carcinomas is rising in the Western World. This increase has been attributed to changes in the etiology of oropharyngeal carcinomas with a growing role for infections with Human Papilloma viruses. This nationwide study evaluates and compares t...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.06.011

    authors: van Monsjou HS,Schaapveld M,van den Brekel MW,Balm AJ

    更新日期:2015-10-01 00:00:00

  • Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: A population-based study.

    abstract:PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.10.013

    authors: van Monsjou HS,Schaapveld M,Hamming-Vrieze O,de Boer JP,van den Brekel MW,Balm AJ

    更新日期:2016-01-01 00:00:00

  • The prognostic significance of age in oropharyngeal squamous cell carcinoma.

    abstract:OBJECTIVES:Though the effect of age has been studied in some cancer types, its prognostic significance in oropharyngeal squamous cell carcinoma (OPSCC) remains controversial. Our purpose is to determine the impact of age at diagnosis on overall survival (OS) and disease-specific survival (DSS) in patients with OPSCC. I...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2013.12.013

    authors: Ryan Camilon P,Stokes WA,Nguyen SA,Lentsch EJ

    更新日期:2014-05-01 00:00:00

  • N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer.

    abstract:OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.08.003

    authors: Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

    更新日期:2013-02-01 00:00:00

  • Tube feeding during treatment for head and neck cancer - Adherence and patient reported barriers.

    abstract:OBJECTIVES:The main aim was to investigate the incidence of patient adherence to nutritional tube feeding recommendations in patients with head and neck cancer and to determine patient barriers to meeting tube feeding prescription. MATERIALS AND METHODS:This was an observational study from a randomised controlled tria...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2017.07.017

    authors: Brown T,Banks M,Hughes BGM,Lin C,Kenny L,Bauer J

    更新日期:2017-09-01 00:00:00

  • Merkel cell carcinoma of the head and neck.

    abstract::Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Incidence rates increase with sun exposure and after immunosuppression and organ transplantation. A significant proportion of MCC have been reported to...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2003.11.005

    authors: Suárez C,Rodrigo JP,Ferlito A,Devaney KO,Rinaldo A

    更新日期:2004-09-01 00:00:00

  • The eating experience after treatment for head and neck cancer: A review of the literature.

    abstract:PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2015.04.014

    authors: Ganzer H,Touger-Decker R,Byham-Gray L,Murphy BA,Epstein JB

    更新日期:2015-07-01 00:00:00

  • Serum C-reactive protein as a prognostic indicator in patients with oral squamous cell carcinoma.

    abstract::Preoperative elevation of serum C-reactive protein (CRP) has been demonstrated as a prognostic indicator in oesophageal, gastric and colorectal cancer. This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamou...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2009.03.015

    authors: Khandavilli SD,Ceallaigh PO,Lloyd CJ,Whitaker R

    更新日期:2009-10-01 00:00:00

  • Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

    abstract:BACKGROUND:Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2019.02.006

    authors: El-Salem F,Mansour M,Gitman M,Miles BA,Posner MR,Bakst RL,Genden EM,Westra WH

    更新日期:2019-03-01 00:00:00

  • Staging and IgA VCA titre in patients with nasopharyngeal carcinoma: changes over a 12-year period.

    abstract::The distributions of 2093 patients with nasopharyngeal carcinoma (NPC), by stage, over a 12-year-period did not show any evidence of a shift towards early stages despite growing awareness of this prevalent malignancy. The IgA VCA titre was determined for 1880 of these patients. The median titre increased from 40 in st...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(98)00063-3

    authors: Ho S,Teo P,Kwan WH,Choi P,Tjong J,Johnson PJ

    更新日期:1998-11-01 00:00:00

  • Eosinophil ablation and tumor development.

    abstract::Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(99)00023-8

    authors: Wong DT,Bowen SM,Elovic A,Gallagher GT,Weller PF

    更新日期:1999-09-01 00:00:00

  • Reprint of Long-term survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by high-total- and fractionated-dose simultaneous modulated accelerated radiotherapy with or without chemotherapy.

    abstract:BACKGROUND:To analyse the survival and late toxicities of elderly nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT) with the high-total- and fractionated-dose simultaneous modulated accelerated radiation therapy (SMART) boost technique and to identify the effect of concurrent ch...

    journal_title:Oral oncology

    pub_type: 已发布勘误

    doi:10.1016/j.oraloncology.2019.01.005

    authors: Miao J,Wang L,Zhu M,Xiao W,Wu H,Di M,Huang Y,Huang S,Han F,Deng X,Guo X,Zhao C

    更新日期:2019-03-01 00:00:00

  • Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT.

    abstract:BACKGROUND:The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically a...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.09.014

    authors: Studer G,Glanzmann C

    更新日期:2013-03-01 00:00:00

  • Comparative study of sentinel lymph node biopsy in clinically N0 oral tongue squamous cell carcinoma: Long-term oncologic outcomes between validation and application phases.

    abstract:OBJECTIVE:This study tested the long-term outcomes of sentinel lymph node biopsy (SLNB) for oral tongue squamous cell carcinoma (SCC) during the transition from validation to application phase. MATERIALS AND METHODS:Sensitivity, negative predictive value (NPV), neck control rate, disease-specific survival (DSS), disea...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2015.07.007

    authors: Chung MK,Lee GJ,Choi N,Cho JK,Jeong HS,Baek CH

    更新日期:2015-10-01 00:00:00

  • Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines.

    abstract::Toll-like receptor 4 (TLR4) plays a significant role in cancer therapy as receptors of bacteria-derived immunotherapeutic agents such as OK-432, a streptococcal immunotherapeutic agent. In addition, recent reports demonstrated that TLRs, including TLR4, are also expressed in cancer cells as well as in immunocompetent ...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2012.02.005

    authors: Tano T,Okamoto M,Kan S,Nakashiro K,Shimodaira S,Yamashita N,Kawakami Y,Hamakawa H

    更新日期:2012-08-01 00:00:00

  • A network meta-analysis in comparing prophylactic treatments of radiotherapy-induced oral mucositis for patients with head and neck cancers receiving radiotherapy.

    abstract:OBJECTIVES:The objective of this network meta-analysis is to optimize the prophylactic treatment for radiotherapy-induced oral mucositis in patients with head and neck cancer (HNSCC) receiving postoperative or definitive radiotherapy with or without chemotherapy. MATERIALS AND METHODS:We searched electronic databases ...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.oraloncology.2017.11.001

    authors: Peng H,Chen BB,Chen L,Chen YP,Liu X,Tang LL,Mao YP,Li WF,Zhang Y,Lin AH,Sun Y,Ma J

    更新日期:2017-12-01 00:00:00

  • Spindle-cell lipoma of the cheek: a case report.

    abstract::Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/s1368-8375(00)00035-x

    authors: Piattelli A,Rubini C,Fioroni M,Iezzi G

    更新日期:2000-09-01 00:00:00

  • Pediatric intraosseous hemangioma of the anterior mandible.

    abstract::Intraosseous hemangioma is a benign vascular neoplasm and seldom affects the mandible. The diagnosis is challenging owing to its unspecific clinical and radiographic findings. Treatment options in children should be elective based on their age, symptoms, and facial deformity. Herein a rare case of intraosseous hemangi...

    journal_title:Oral oncology

    pub_type: 信件

    doi:10.1016/j.oraloncology.2020.104951

    authors: Madiraju GS

    更新日期:2020-09-01 00:00:00

  • Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis.

    abstract:INTRODUCTION:Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic...

    journal_title:Oral oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.oraloncology.2016.12.031

    authors: Mercadante V,Al Hamad A,Lodi G,Porter S,Fedele S

    更新日期:2017-03-01 00:00:00

  • Staging and prognosis in head and neck cancer.

    abstract::Head and neck malignant tumors are classified according to the TNM staging system. The TNM system is a universally accepted, widely used, staging method. Its goals are to help clinicians and researchers to choose from treatment options, to give patients an estimate of their prognosis and to compare results of treatmen...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2008.05.022

    authors: van der Schroeff MP,Baatenburg de Jong RJ

    更新日期:2009-04-01 00:00:00

  • Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer.

    abstract::Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this st...

    journal_title:Oral oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.oraloncology.2005.10.002

    authors: Bagg J,Jackson MS,Petrina Sweeney M,Ramage G,Davies AN

    更新日期:2006-05-01 00:00:00

  • Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.

    abstract::Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies, including oral cancers. Recent studies have shown that mast cell-derived protease tryptase can induce COX-2 expression by the cleavage of proteinase-activated receptor-2 (PAR-2). Actinic cheilitis (AC) is a premalignant form of lip cance...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2008.05.019

    authors: Rojas IG,Martínez A,Brethauer U,Grez P,Yefi R,Luza S,Marchesani FJ

    更新日期:2009-03-01 00:00:00

  • Adaptive radiotherapy for head and neck cancer: Are we ready to put it into routine clinical practice?

    abstract::Patients with head and neck cancer who are treated with radiotherapy often have significant weight loss or tumor regression during treatment. Adaptive radiotherapy refers to acquiring new imaging during treatment and changing the parameters of the radiation plan based on the new imaging findings. There is accumulating...

    journal_title:Oral oncology

    pub_type: 杂志文章,评审

    doi:10.1016/j.oraloncology.2018.08.010

    authors: Gensheimer MF,Le QT

    更新日期:2018-11-01 00:00:00

  • p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.

    abstract::We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines differing in TP53 sta...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2010.10.011

    authors: Roh JL,Kang SK,Minn I,Califano JA,Sidransky D,Koch WM

    更新日期:2011-01-01 00:00:00

  • Type I and III collagen degradation products in serum predict patient survival in head and neck squamous cell carcinoma.

    abstract::Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2011.09.002

    authors: Nurmenniemi S,Koivula MK,Nyberg P,Tervahartiala T,Sorsa T,Mattila PS,Salo T,Risteli J

    更新日期:2012-02-01 00:00:00

  • The upregulation of metallothionein-1 expression in areca quid chewing-associated oral squamous cell carcinomas.

    abstract::Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, inducible, intracellular proteins that bind heavy metals with high affinity. MT-1 is known as a stress-inducible protein and functions as an antioxidant enzyme. Areca quid chewing is a major risk factor in the development and further progressi...

    journal_title:Oral oncology

    pub_type: 杂志文章

    doi:10.1016/j.oraloncology.2007.01.019

    authors: Lee SS,Yang SF,Ho YC,Tsai CH,Chang YC

    更新日期:2008-02-01 00:00:00