Evaluation of TS-1 based treatment and expression of thymidylate synthase and dihydropyrimidine dehydrogenase on oral squamous cell carcinoma.

abstract：:The recently identified single nucleotide polymorphism in the MDM2 promoter (SNP 309) may contribute to the early onset of both sporadic and hereditary malignancies in patients with defective p53. We tested this hypothesis by examining the effects of combined MDM2 polymorphisms and somatic p53 mutations on 351 oral sq...

journal_title：Oral oncology

authors： Huang SF,Chen IH,Liao CT,Wang HM,Liou SH,Hsieh LL

更新日期：2009-01-01 00:00:00

abstract：:We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...

journal_title：Oral oncology

authors： Mori A,Tagawa T,Kamei T,Murata T,Inui M,Ohse S

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:We evaluated the effects of three-dimensional virtual planning and the use of a plate-embedded surgical guide in mandibular reconstruction with microvascular fibula flaps. MATERIALS AND METHODS:We retrospectively reviewed 35 patients who underwent primary mandibular reconstruction with a free fibula flap. T...

journal_title：Oral oncology

authors： Bao T,He J,Yu C,Zhao W,Lin Y,Wang H,Liu J,Zhu H

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication. METHOD:Systematic ...

journal_title：Oral oncology

authors： Farooq S,Khandavilli S,Dretzke J,Moore D,Nankivell PC,Sharma N,Almeida JR,Winter SC,Simon C,Paleri V,De M,Siddiq S,Holsinger C,Ferris RL,Mehanna H

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:This study investigated whether the methylation of ZNF582, PAX1, SOX1, NKX6.1, and PTPRR genes in oral scrapings could be used to detect oral dysplasia and oral cancer and to predict oral cancer recurrence. MATERIALS AND METHODS:Oral scrapings were collected from 65 normal oral mucosa subjects, 107 oral pre...

journal_title：Oral oncology

authors： Cheng SJ,Chang CF,Lee JJ,Chen HM,Wang HJ,Liou YL,Yen C,Chiang CP

更新日期：2016-11-01 00:00:00

abstract：:Oral cancer is a multifactorial disease in which both environmental and genetic factors contribute to the aetiopathogenesis. Oral cancer is the sixth most common cancer worldwide with a higher incidence among Melanesian and South Asian countries. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC). T...

journal_title：Oral oncology

authors： Salahshourifar I,Vincent-Chong VK,Kallarakkal TG,Zain RB

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo)radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity. MATERIALS AND METHODS:Between 1999 and 2010, 82 consecutive patients with PNSC were...

journal_title：Oral oncology

authors： Al-Mamgani A,Monserez D,Rooij Pv,Verduijn GM,Hardillo JA,Levendag PC

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this study was to assess the accuracy of this tissue staining assessment of surgical specimens in delineating deep surgical margins in oral cancer surgery. Fifteen patients who underwent surgery for oral carcinoma were included in the study. Once the tumor was resected, a vertical section of the surgica...

journal_title：Oral oncology

authors： Kurita H,Sakai H,Kamata T,Koike T,Kobayashi H,Kurashina K

更新日期：2008-10-01 00:00:00

abstract：:Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different ...

journal_title：Oral oncology

authors： Rangiani A,Motahhary P

更新日期：2009-07-01 00:00:00

abstract：:The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMe...

journal_title：Oral oncology

authors： Schuch LF,de Arruda JAA,Silva LVO,Abreu LG,Silva TA,Mesquita RA

更新日期：2018-10-01 00:00:00

abstract：:To examine the influence of smoking on observer based morbidity scores and patient assessed health related quality of life after treatment for head and neck cancer. The results of EORTC C30 and H&N35 questionnaires and DAHANCA morbidity scores were studied according to smoking status in 114 recurrence free head and ne...

journal_title：Oral oncology

authors： Jensen K,Jensen AB,Grau C

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs1799752) varian...

journal_title：Oral oncology

authors： Liu YT,Lin LW,Chen CY,Wang CP,Liu HP,Houng JY,Chung FM,Shieh TY

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:The aim of the present study was to evaluate whether texture features extracted from 18F-FDG PET/CT images may provide additional prognostic information in patients with metastatic nasopharyngeal carcinoma (NPC). MATERIALS AND METHOD:We retrospectively examined 52 patients with metastatic NPC who underwent ass...

journal_title：Oral oncology

authors： Lin HC,Chan SC,Cheng NM,Liao CT,Hsu CL,Wang HM,Lin CY,Chang JT,Ng SH,Yang LY,Yen TC

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS:Ret...

journal_title：Oral oncology

authors： Wang J,Tan Y,Shen Y,Lv M,Li J,Sun J

更新日期：2020-03-01 00:00:00

abstract：:The etiology of oral squamous cell carcinoma has been linked to environmental carcinogens, such as activated aromatic heterocyclic radicals and epoxides. Our previous work on implantable and 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer showed that oral glutamine (GLN) inhibited tumor growth possibly thr...

journal_title：Oral oncology

authors： Lim V,Korourian S,Todorova VK,Kaufmann Y,Klimberg VS

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:A standardized assay to determine the HPV status of head and neck squamous cell carcinoma (HNSCC) specimens has not yet been established, particularly for cytologic samples. The goal of this study was to determine whether the hybrid capture-2 (HC-2) assay, already widely used for the detection of high risk HP...

journal_title：Oral oncology

authors： Smith DF,Maleki Z,Coughlan D,Gooi Z,Akpeng B,Ogawa T,Bishop JA,Frick KD,Agrawal N,Gourin CG,Ha PK,Koch WM,Richmon JD,Westra WH,Pai SI

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:examine the cost-effectiveness of routine Calcitonin (Ctn) screening test in the United States. MATERIALS AND METHODS:Markov chain model was developed that compares fine-needle aspiration biopsy (FNAB) with Ctn screening vs. FNAB-only in the evaluation of a thyroid nodule with non-highly suspicious findings...

journal_title：Oral oncology

authors： Al-Qurayshi Z,Kandil E,Randolph GW

更新日期：2020-11-01 00:00:00

abstract：:The objective of this study was to analyze the role of adjuvant chemotherapy and prognostic factors in malignant mucosal melanoma of the head and neck (HNMM). Thirty-two patients with mucosal melanoma of the head and neck who received local treatment with or without adjuvant chemotherapy were reviewed. Clinicopatholog...

journal_title：Oral oncology

authors： Ahn HJ,Na II,Park YH,Cho SY,Lee BC,Lee GH,Koh JS,Lee YS,Shim YS,Kim YK,Kang HJ,Ryoo BY,Yang SH

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:To characterize specific serious toxicities of reRT with intensity modulated radiation therapy (IMRT) for squamous cell carcinoma of the head and neck (SCCHN) and identify treatment-related predictors of toxicity for patient counseling and decision-making. MATERIALS/METHODS:75 consecutive patients with recu...

journal_title：Oral oncology

authors： Margalit DN,Schoenfeld JD,Rawal B,Haddad RI,Catalano PJ,Goguen LA,Chau NG,Rabinowits G,Lorch JH,Annino DJ,Tishler RB

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:Overexpression of the epidermal growth factor (EGF) receptor (EGFR) gene in the squamous cell carcinomas of the head and neck (SCCHN) is often associated with inauspicious prognosis and poor survival. N-acetylcysteine (NAC), a compound from some vegetables and allium species, appears anti-tumorigenesis, but ...

journal_title：Oral oncology

authors： Lee MF,Chan CY,Hung HC,Chou IT,Yee AS,Huang CY

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Elective neck dissection (END) for salvage laryngectomy remains controversial due to variability in reported occult nodal metastasis rates and postoperative complications. We performed a meta-analysis to examine the role of END for treatment of the clinically N0 (cN0) neck in the salvage setting. METHODS:A P...

journal_title：Oral oncology

authors： Lin C,Puram SV,Bulbul MG,Sethi RK,Rocco JW,Old MO,Kang SY

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...

journal_title：Oral oncology

authors： Saeed AA,Sims AH,Prime SS,Paterson I,Murray PG,Lopes VR

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:Results of the Dutch multi-institutional trial on sentinel lymph node (SLN) biopsy in oral cancer. PATIENTS AND METHODS:Patients were consecutively enrolled from 4 institutions, with T1/T2 oral cancer and cN0 neck based on palpation and ultrasound guided fine needle aspiration cytology. Lymphatic mapping co...

journal_title：Oral oncology

authors： Flach GB,Bloemena E,Klop WM,van Es RJ,Schepman KP,Hoekstra OS,Castelijns JA,Leemans CR,de Bree R

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...

journal_title：Oral oncology

authors： Antunes HS,Schluckebier LF,Herchenhorn D,Small IA,Araújo CM,Viégas CM,Rampini MP,Ferreira EM,Dias FL,Teich V,Teich N,Ferreira CG

更新日期：2016-01-01 00:00:00

abstract：:Previous work from our laboratory has demonstrated overexpression of chemokines in head and neck cancer and the utility of targeting these proteins for tumor therapy in a preclinical model. However, the mechanisms involved are unexplored. Through gene expression analysis, we found that expression of vascular endotheli...

journal_title：Oral oncology

authors： Benke EM,Ji Y,Patel V,Wang H,Miyazaki H,Yeudall WA

更新日期：2010-04-01 00:00:00

abstract：:Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI. Mice bearing CAL...

journal_title：Oral oncology

authors： Bozec A,Formento P,Fischel JL,Etienne-Grimaldi MC,Milano G

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:To characterize the representation of women in clinical trials directing the National Comprehensive Cancer Network (NCCN) guidelines for chemotherapy use in head and neck squamous cell carcinoma (HNSCC), as well as the relationship between gender and chemotherapy administration in the definitive treatment of...

journal_title：Oral oncology

authors： Benchetrit L,Torabi SJ,Tate JP,Mehra S,Osborn HA,Young MR,Burtness B,Judson BL

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Comorbid conditions impact outcome for patients treated for oropharyngeal squamous cell carcinoma (OPSCC) and serve as competing risk factors for death. The purpose of this study was to examine differences in comorbidities in patients with OPSCC and known HPV-DNA. MATERIAL AND METHODS:We included patients d...

journal_title：Oral oncology

authors： Grønhøj C,Kronberg Jakobsen K,Kjær E,Friborg J,von Buchwald C

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Nasopharyngeal carcinoma (NPC) is common in Southeast Asia. Due to the influx of immigrants from this region, the incidence in British Columbia is increasing. Current literature from non-endemic populations encompasses heterogeneous cohorts. This study examines NPC in a North American population, with a high ...

journal_title：Oral oncology

authors： Howlett J,Hamilton S,Ye A,Jewett D,Riou-Green B,Prisman E,Thamboo A

更新日期：2021-01-24 00:00:00

abstract：:The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis' pathogenesis until relatively recently. More frustrating for patients and clinici...

journal_title：Oral oncology

authors： Sonis ST

更新日期：2009-12-01 00:00:00